Table 5. . Differentially methylated probes in pre-symptomatic dementia versus controls at baseline.
| Gene | Probe | Hg19 location | Case mean | Control mean | Δ | 95% CI | p-value |
|---|---|---|---|---|---|---|---|
| APOE | cg16471933 | chr19:45411802 | 69.18% | 67.14% | 2.04% | 0.51–3.57% | 0.009 |
| cg18799241 | chr19:45412599 | 80.15% | 79.21% | 0.91% | 0.12–1.70% | 0.02 | |
| APP | cg11278459 | chr21:27210355 | 52.43% | 56.18% | 3.75% | 1.53–5.98% | 0.001 |
| cg17660372 | chr21:27305727 | 83.42% | 82.38% | 1.04% | 0.22–1.86% | 0.01 | |
| cg04424048 | chr21:27306084 | 68.42% | 66.97% | 1.44% | 0.12–2.77% | 0.03 | |
| cg08542030 | chr21:27306498 | 78.07% | 76.66% | 1.41% | 0.21–2.61% | 0.02 | |
| cg07896369 | chr21:27326987 | 83.77% | 84.51% | -0.75% | -0.02 to -1.47% | 0.04 | |
| cg17728373 | chr21:27404776 | 60.51% | 58.34% | 2.16% | 0.23–4.10% | 0.03 | |
| cg23830184 | chr21:27425841 | 77.84% | 78.93% | -1.09% | -0.09 to 2.09% | 0.03 | |
| cg22552084 | chr21:27497496 | 63.69% | 61.80% | 1.90% | 0.25–3.55% | 0.03 | |
| cg19591392 | chr21:27513218 | 64.04% | 66.42% | -2.38% | -0.16 to -4.59% | 0.04 | |
| cg15407086 | chr21:27543045 | 17.08% | 14.99% | 2.09% | 1.05–3.12% | 0.0001 | |
| cg27158854 | chr21:27543469 | 8.77% | 8.34% | 0.43% | 0.15–0.71% | 0.003 | |
| cg08866780 | chr21:27543523 | 11.80% | 10.65% | 1.15% | 0.26–2.05% | 0.01 | |
| cg01148198 | chr21:27544373 | 75.19% | 74.33% | 0.87% | 0.09–1.68% | 0.03 | |
| cg03015479 | chr21:27544797 | 69.91% | 68.09% | 1.82% | 0.10–3.53% | 0.04 | |
| cg23393368 | chr21:27561643 | 69.52% | 67.75% | 1.77% | 0.26–3.28% | 0.02 | |
| cg19933173 | chr21:27562920 | 65.04% | 60.73% | 4.31% | 2.28–6.33% | <0.0001 | |
| BDNF | cg23330212 | chr11:27672697 | 57.91% | 56.07% | 1.83% | 0.05–3.62% | 0.04 |
| cg14291693 | chr11:27683959 | 64.07% | 61.92% | 2.15% | 0.48–3.81% | 0.01 | |
| cg08362738 | chr11:27722636 | 5.53% | 6.03% | -0.49% | -0.07 to -0.91% | 0.02 | |
| cg25328597 | chr11:27722638 | 5.80% | 6.19% | -0.39% | -0.00001 to -0.78% | 0.05 | |
| cg04672351 | chr11:27722889 | 5.81% | 5.53% | 0.28% | 0.03–0.54% | 0.03 | |
| cg05733135 | chr11:27740876 | 24.75% | 27.37% | -2.62% | -0.31 to -4.92% | 0.03 | |
| cg22043168 | chr11:27741077 | 28.96% | 30.27% | -1.31% | -0.25 to -2.37% | 0.02 | |
| cg26949694 | chr11:27742060 | 16.82% | 17.86% | -1.05% | -0.12 to -1.97% | 0.03 | |
| cg01225698 | chr11:27742355 | 10.66% | 11.70% | -1.05% | -0.14 to -1.96% | 0.02 | |
| cg27351358 | chr11:27743258 | 7.21% | 8.13% | -0.92% | -0.13 to -1.71% | 0.02 | |
| PIN1 | cg06539622 | chr19:9945676 | 4.85% | 5.29% | -0.43% | -0.06 to -0.81% | 0.03 |
| SNCA | cg01681236 | chr4:90647041 | 79.33% | 77.96% | 1.37% | 0.33–2.41% | 0.01 |
| cg06176111 | chr4:90674837 | 63.72% | 62.15% | 1.57% | 0.03–3.11% | 0.05 | |
| cg17045024 | chr4:90758207 | 17.00% | 18.89% | -1.89% | -0.14 to -3.64% | 0.04 | |
| cg01035160 | chr4:90758529 | 5.46% | 6.10% | -0.62% | -0.12 to -1.11% | 0.01 | |
| cg00119181 | chr4:90758537 | 7.21% | 8.40% | -1.20% | -0.01 to -2.38% | 0.05 | |
| TOMM40 | cg08267701 | chr19:45393621 | 5.19% | 4.94% | 0.24% | 0.02–0.47% | 0.04 |
| cg22024783 | chr19:45393916 | 17.89% | 16.36% | 1.53% | 0.53–2.53% | 0.003 | |
| cg27534894 | chr19:45393925 | 13.11% | 11.77% | 1.34% | 0.48–2.20% | 0.002 | |
| cg21549639 | chr19:45394156 | 6.81% | 6.40% | 0.43% | 0.13–0.72% | 0.004 | |
| cg27443666 | chr19:45394427 | 2.85% | 3.00% | -0.15% | -0.002 to -0.29% | 0.05 |