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. 2021 Mar 4;108(3):530–531. doi: 10.1016/j.ajhg.2021.01.014

Rare and de novo coding variants in chromodomain genes in Chiari I malformation

Brooke Sadler, Jackson Wilborn, Lilian Antunes, Timothy Kuensting, Andrew T Hale, Stephen R Gannon, Kevin McCall, Carlos Cruchaga, Matthew Harms, Norine Voisin, Alexandre Reymond, Gerarda Cappuccio, Nicola Brunetti-Pierri, Marco Tartaglia, Marcello Niceta, Chiara Leoni, Giuseppe Zampino, Allison Ashley-Koch, Aintzane Urbizu, Melanie E Garrett, Karen Soldano, Alfons Macaya, Donald Conrad, Jennifer Strahle, Matthew B Dobbs, Tychele N Turner, Chevis N Shannon, Douglas Brockmeyer, David D Limbrick, Christina A Gurnett, Gabe Haller
PMCID: PMC8008482  PMID: 33667397

(The American Journal of Human Genetics 108, 100–114; January 7, 2021)

Three variants were misnamed in the text and mislabeled in Figure 2. The relevant sentence has been changed to read, “The three de novo CHD8 mutations observed in CM1 include two stop-gain mutations (GenBank: NM_001170629.2; c.4414C>T [p.Arg1472] and c.4514G>A [p.Trp1505]) and a splice donor site mutation (c.2907+1G>T [p.?]).” These errors have been corrected online. The authors apologize for these errors.

Figure 2.

Figure 2

CHD8 loss-of-function de novo mutations in individuals with CM1 (corrected)

Figure 2.

Figure 2

CHD8 loss-of-function de novo mutations in individuals with CM1 (original)


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