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. 2021 Mar 31;37(3):443–449. doi: 10.1007/s40242-021-1006-9

Electrospun Aspirin/Eudragit/Lipid Hybrid Nanofibers for Colon-targeted Delivery Using an Energy-saving Process

Yibin Wang 1,#, Liang Tian 1,#, Tianhao Zhu 1, Jing Mei 1, Zezhong Chen 1,✉, Deng-Guang Yu 1,2,✉
PMCID: PMC8010490  PMID: 33814861

Abstract

Both electrospinning apparatus and their commercial products are extending their applications in a wide variety of fields. However, very limited reports can be found about how to implement an energy-saving process and in turn to reduce the production cost. In this paper, a brand-new type of coaxial spinneret with a solid core and its electrospinning methods are developed. A novel sort of medicated Eudragit/lipid hybrid nanofibers are generated for providing a colon-targeted sustained release of aspirin. A series of characterizations demonstrates that the as-prepared hybrid nanofibers have a fine linear morphology with the aspirin/lipid separated from the matrix Eudragit to form many tiny islands. In vitro dissolution tests exhibit that the hybrid nanofibers are able to effectively prevent the release of aspirin under an acid condition (8.7%±3.4% for the first two hours), whereas prolong the drug release time period under a neutral condition(99.7±4.2% at the seventh hour). The energy-saving mechanism is discussed in detail. The prepared aspirin-loaded hybrid nanofibers can be further transferred into an oral dosage form for potential application in countering COVID-19 in the future.

Keywords: Coaxial spinneret, Polymer/lipid hybrid fibers, Colon-targeted, Aspirin, COVID-19

Acknowledgements

This study was supported by the Natural Science Foundation of Shanghai, China(No.20ZR1439000) and the USST college student innovation projects, China(Nos.SH2020227 & XJ2020376-2020378).

Conflicts of Interest

The authors declare no conflicts of interest.

Footnotes

These authors contributed equally to this work.

Contributor Information

Zezhong Chen, Email: zzhchen@usst.edu.cn.

Deng-Guang Yu, Email: ydg017@usst.edu.cn.

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