Table 1.
Association of total plasma EETs and DHETs with incident diabetes among 1161 participants in the Strong Heart Family Study.
| Model 1* |
Model 2* |
|||||
|---|---|---|---|---|---|---|
| RR† | 95% CI | P^ | RR† | 95% CI | P^ | |
| 14,15-EET | 1.05 | (0.95, 1.16) | 0.30 | 1.02 | (0.93, 1.12) | 0.69 |
| 11,12-EET | 1.04 | (0.93, 1.16) | 0.50 | 1.00 | (0.90, 1.12) | 1.00 |
| 8,9-EET | 1.10 | (1.00, 1.20) | 0.06 | 1.07 | (0.98, 1.18) | 0.14 |
| 5,6-EET | 1.06 | (0.96, 1.18) | 0.22 | 1.03 | (0.94, 1.13) | 0.54 |
| 14,15-DHET | 0.90 | (0.80, 1.01) | 0.07 | 0.94 | (0.85, 1.05) | 0.30 |
| 11,12-DHET | 0.98 | (0.86, 1.11) | 0.71 | 1.01 | (0.89, 1.14) | 0.89 |
| 8,9-DHET | 1.01 | (0.88, 1.17) | 0.87 | 1.08 | (0.95, 1.22) | 0.25 |
| 5,6-DHET | 1.03 | (0.91, 1.18) | 0.62 | 1.14 | (1.00, 1.30) | 0.04 |
Abbreviations: EET=Epoxyeicosatrienoic Acid; DHET= Dihydroxyeicosatrieonic acid
⁎
Model 1 included adjustments for age, sex, site; Model 2 included age, sex, site, education, smoking, physical activity, BMI, waist circumference and LDL levels.
†
RR: Relative risk of incident diabetes associated with one SD higher log EET/DHET species
^
Inverse-probability-of-being-sampled weighted Wald's test with robust sandwich variance and within-family-cluster exchangeable working correlation matrix under a Weibull time-to-event model with interval censoring (evidence from 20 imputations combined using Rubin's rules).