Table 4. Milfetosine use in primary amoebic meningoencephalitis.

AmB: amphotericin B, Rif: rifampin, Flu: fluconazole, AZM: azithromycin, Dex: dexamethasone, Acy: acyclovir, Van: vancomycin, CFX: ceftriaxone, Deoxy AmB IV: deoxycholate amphotericin B intravenously, ICU: intensive care unit

Reference	Case (age, sex)	Diagnosis from symptoms onset	Initial treatment¹	Miltefosine initiation from diagnosis	Total days of treatment	Outcome	Follow up
[18]	12-year-old, female	two days	AmB, Rif, Flu, AZM, Dex	36 hours	55 days	Survive	Full recovery after three months, with speech and physical therapy
[20]	12-year-old, male	one day	Acy, liposomal AmB, Rif, Flu, Van, CFX , IV Deoxy AmB, Flu, AZM, Rif	31 hours	16 days	Dead	Braindead on hospital day 16
[20]	Eight-year-old, male	five days	AmB, Rif, Flu, AZM, Dex	14 hours from ICU admission	39 days	Survive	Significant neurological deficits
[21]	44-year-old male	four days	IV/IT AmB, Flu, Rif, Dex	Within 24 hours	four days	Dead	Diabetes Insipidus on day three, Cardiac arrest on day four
[22]	4-year-old male	for – five days	LOR, Phos AZM, AmB, Rif, Flu, Dex	24 - 48 hours	two days	Dead	Braindead on hospital day two
[22]	14-year-old male	three – five days	Van, CFX, Flu, AZM, Rif, IV/IT AmB	24 - 92 hours	four days	Dead	Brain herniation, later braindead on hospital day four