Table 5. Case report of a patient with meningoencephalitis due to GAE.

AmB: amphotericin B, TB: tuberculosis, GAE: granulomatous amebic encephalitis

Reference	Case (age, sex)	Diagnosis from symptoms to onset	Initial treatment	Miltefosine Initiation from diagnosis	Total days of treatment	Outcome	Follow-up
[25]	60 years, female	20 days	AmB, metronidazole and surgical resection	Hospital day four	Six months for resolution of lesions	Survived	Full recovery with eight months of therapy to prevent relapse
[26]	25 years, male	Six weeks	TB regimen, surgical excision, and amikacin	12 weeks after tuberculosis s therapy	Six weeks of amikacin, eight weeks of miltefosine	Survived	Two years follow up without relapse
[27]	38 years, male	Months later	Voriconazole, plus surgical excision	Months	Three months	Survived	Information not found
[28]	35, male	Two weeks	Miltefosine, fluconazole, albendazole, azithromycin, rifampin, and TMX	10 days	Four weeks	Died	He was surgically intervened, but, eventually, died
[29]	35, male	Years	HAART, fluconazole, TMX, and miltefosine	Day 13	Seven days because of gastrointestinal intolerance	Survived	After seven months, he eventually recovered from the infection
[30]	63, male	Two weeks	Dex, surgical excision, sulfadiazine, fluconazole, flucytosine, and azithromycin	10 days	Four weeks	Died	Died due to declining kidney function and pancytopenia