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. 2021 Mar 22;12:671443. doi: 10.3389/fimmu.2021.671443

Corrigendum: High-Dose Intravenous Immunoglobulin in Severe Coronavirus Disease 2019: A Multicenter Retrospective Study in China

Wei Cao 1,, Xiaosheng Liu 1,2,3,, Ke Hong 4, Zhiyong Ma 5, Yuelun Zhang 6, Ling Lin 1, Yang Han 1, Yong Xiong 5, Zhengyin Liu 1, Lianguo Ruan 4, Taisheng Li 1,2,3,*
PMCID: PMC8020904  PMID: 33831136

Error in Table

In the original article, there was a mistake in Table 1 as published. The author identified the calculating errors in the percentage of comorbidity, symptoms, and treatment. The corrected Table 1 appears below.

Table 1.

Clinical and relevant baseline characteristics of patients.

Characteristic Total (n = 115) IVIg group (n = 26) Control group (n = 89) SD (%)
Demographics
Age, median (IQR) 59 (47–69) 58 (42–65) 59 (48–70) 16
Male sex, No. (%) 76 (66) 19 (73) 57 (64) 18
Any comorbidity, No. (%)
 Hypertension 52 (45) 10 (38) 42 (47) 9
 Diabetes 24 (21) 2 (8) 22 (25) 39
 Chronic cardiac disease 18 (16) 5 (19) 13 (15) 11
 Chronic respiratory disease 11 (10) 2 (8) 9 (10) 4
Any symptoms, No. (%)
 Fever 111 (97) 22 (85) 89 (100) 31
 Cough 97 (84) 22 (85) 75 (84) 8
 Dyspnea 96 (83) 22 (85) 74 (83) 10
 Fatigue or myalgia 52 (45) 9 (35) 43 (48) 19
 Diarrhea 30 (26) 4 (15) 26 (29) 24
Vital signs
 Systolic BP, mm Hg 132 ± 19 131 ± 14 133 ± 20 5
 HR,/min 88 (80–102) 85 (81–100) 89 (80–105) 9
 RR, breaths/min 22 (20–25) 22 (20–23) 22 (20–25) 2
 SPO2, % 90 (87–94) 91 (89–94) 89 (86–92) 6
Complete blood count
 WBCs, × 109/L 6.59 (4.38–9.64) 6.25 (4.15–10.28) 6.60 (4.42–9.56) 4
 LYM, × 109/L 0.76 (0.57–1.02) 0.90 (0.62–1.05) 0.73 (0.56–0.91) 19
 PLT, × 109/L 191 (148–269) 172 (144–279) 199 (150–270) 18
Inflammatory biomarkers
 IL–6, pg/mL 13.0 (8.0–31.5) 15.5 (10.5–34.0) 11.0 (7.2–32.2) 15
 IL–8, pg/mL 15.2 (6.0–27.3) 16.2 (5.8–23.8) 15.2 (5.9–28.4) 3
 IL–10, pg/mL 5.2 (5.0–10.3) 5.0 (5.0–8.5) 5.5 (5.0–11.2) 2
 hsCRP, mg/L 48 (17–94) 28 (7–91) 45 (17–101) 14
 Ferritin, ng/mL 807.0 (473.4–1383.3) 774.1 (444.2–1525.4) 838.8 (501.5–1351.1) 18
 ESR, mm/h 50 (25–65) 35 (19–67) 50 (27–65) 14
Immunoglobulins
 IgA, g/L 2.2 (1.8–3.0) 2.7 (1.9–4.6) 2.2 (1.6–3.0) 2
 IgG, g/L 11.1 (9.0–13.1) 11.8 (8.5–15.7) 11.1 (9.3–13.1) 2
 IgM g/L 1.0 (0.7–1.2) 1.0 (0.9–1.1) 0.9 (0.7–1.3) 3
Seven–category scales at admission 4.0 ± 0.67 3.85 ± 0.67 4.06 ± 0.66 26
 3, No. (%) 20 (17) 7 (27) 13 (15) 24
 4, No. (%) 79 (69) 17(65) 62 (70) 7
 5, No. (%) 11 (10) 1 (4) 10 (11) 25
 6, No. (%) 5 (4) 1 (4) 4 (4) 3
Murray lung injury scores at admission 3.93 ± 0.22 3.90 ± 0.28 3.94 ± 0.20 11
Time to admission after onset, median (IQR) 10 (7–12) 10 (7–12) 10 (8–12) 5
Earlier (< 7 days), No. (%) 29 (25) 7 (27) 22 (25) 12
Later (between 7–14 days), No. (%) 86 (75) 19 (73) 67 (75) 12
Treatment during hospitalization, No. (%)
 Antiviral treatment 100 (87) 22 (85) 78 (88) 7
 Arbidol 75 (65) 15 (58) 60 (67) 16
 IFN–α 34 (30) 14 (54) 20 (22) 53
 LPV/r 31 (27) 9 (35) 22 (25) 17
 RBV 12 (10) 3 (12) 9 (10) 4
 OSV 33 (29) 8 (31) 25 (28) 5
 Antibiotic treatment 100 (87) 25 (96) 75 (84) 37
 Moxifloxacin 73 (63) 15 (58) 58 (65) 12
 Cefoperazone and tazobactam 47 (41) 13 (50) 34 (38) 19
 Antifungal treatment 11 (10) 5 (19) 6 (7) 29
 TCM 58 (50) 15 (58) 43 (48) 15
 LMWH 19 (16) 4 (15) 15 (17) 3
 Glucocorticoids 71 (62) 18 (69) 53 (60) 17
IVIg therapy 26 (23) 26 (100) 0 (0)
Initiation time, days, median (IQR) 2 (1–4)
Course, days, median (IQR) 5 (5–9)
Amount, g, median (IQR) 122.5 (95.0–213.8)

SD, standard deviation; Tmax, maximal temperature; BP, blood pressure; HR, heart rate; RR, respiratory rate; SPO2, pulse oximeter O2 saturation; WBC, white cell counts; LYM, lymphocyte counts; PLT, platelet counts; IL, interleukin; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IFN-α, Interferon-alfa; LPV/r, lopinavir/ritonavir; RBV, ribavirin; OSV, oseltamivir; TCM, traditional Chinese medicine; LMWH, low molecular weight heparin.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.


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