Table 1.

Calculation of the reporting Odds-Ratios (ROR).

	Reports with the suspected ADR: i.e LQT or TdP or Ventricular arrhythmias	Reports without the suspected ADR
Reports with suspected drugs (exposed: SERMs)	A	B
Reports with control drugs (non-exposed: AIs)	C	D

A: Number of reports of drug-induced arrhythmias (LQT or TdP or ventricular arrhythmias) associated with given drugs (SERMs).

B: Number of reports of other adverse drug reactions associated with given drugs (SERMs).

C: Number of reports of drug-induced arrhythmias associated with control drugs (AIs).

D: Number of reports of other adverse drug reactions associated with control drugs (AIs).

ROR = (A/C)/(B/D) = AD/BC. (1)

Abbreviations: ADR, adverse drug reaction; AIs, aromatase inhibitors; LQT, long QT; SERMs, selective estrogen receptor modulators; TdP, Torsade-de-pointes