Erratum

Following publication of the Research Article by Matthias R Bauer, Rhiannon N Jones, Raysa Khan, Bradley Springett, Felix A Dingler, Lorena Verduci, Ketan J Patel, Alan R Fersht, Andreas C Joerger & John Spencer, titled ‘A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C’, which appeared in the December 2019 issue of Future Medicinal Chemistry (Future Med. Chem. 11[19], 2491–2504 [2019]; DOI: 10.4155/fmc-2019-0181), it has been brought to our attention that the images in Table 1 were published out of order. They have been corrected below and in the full article as follows:

Table 1. . Thermostabilization and dissociation constants of carbazole-based Y220C binders.

Compound ID	R1†	DSF ΔTM [°C]‡	ITC KD [μM]	Compound ID	R1†	DSF ΔTM [°C]‡	ITC KD [μM]
PK083	H	1.0 ± 0.1	125 ± 10§	PK9321		3.2 ± 0.1	5.6 ± 1.1¶
PK9284	Br	3.0 ± 0.1	14.2 ± 2.0¶	PK9322		3.0 ± 0.1	8.3 ± 2.6¶
PK9295		1.3 ± 0.3	62 ± 6.5¶	PK9323		3.4 ± 0.2	5.3 ± 1.4#
PK9296		1.9 ± 0.0	-	PK9324		1.8 ± 0.1	-
PK9304		-0.6 ± 0.0	-	PK9326		0.8 ± 0.1	-
PK9305		0.6 ± 0.0	-	PK9331		1.7 ± 0.1	-
PK9318		3.6 ± 0.2	2.6 ± 0.4#	PK9327		3.1 ± 0.2	-
PK9319		0.5 ± 0.1	-	PK9328		3.3 ± 0.0	1.7 ± 0.2#
PK9320		3.7 ± 0.0	4.1 ± 0.2#	PK9329		0.1 ± 0.0	-

^†All compounds were synthesized as the amine-hydrochloride salt to aid aqueous solubility.

^‡Measured at a compound concentration of 250 μM. Mean values of quadruplicate measurements are shown.

^§Value taken from reference [22].

^¶Single measurement with ITC fit error.

^#Mean value of at least three independent measurements with SEM.

The editors of Future Medicinal Chemistry would like to sincerely apologise for any confusion or inconvenience this may have caused our readers.