Volume 60 (2019) Pages 819-831
A mistake was noticed between the Paper in Press and redacted article version regarding Scheme 2. The level of “SMS + CERT” activity was transposed onto the “Cdase (Golgi)” activity at some point in transitioning between the two versions. This has been corrected and activity is now representative of what is indicated in the figure legend.
Scheme 2.
SL metabolic flux rates in response to Dox. Rates are the calculated slope of label incorporation into the product analyte for a given enzymatic reaction during the time frames established in Figs. 2–5. The CDase enzymatic rates represent time points of the pulse concurrent with label metabolism in the Golgi (60–120 min). Treatments are indicated as follows: vehicle is black, cytostatic dose is blue, and cytotoxic dose is red. Units are pmol labeled product/nmol lipid Pi/min. Percentage vehicle is also given. ∗Rates that are significantly different from vehicle. CERT, ceramide transport protein; VT, vesicular trafficking.