Table 4.
Top-down selected baseline variables associated with trajectory class membership for patients treated with tDCS + placebo, escitalopram + sham tDCS, and placebo + sham tDCS.
| Rapid vs. slow | Rapid vs. no/minimal | Slow vs. no/minimal | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Predictor | OR | z | PFDR | OR | z | PFDR | OR | z | PFDR |
| tDCS | |||||||||
| Treatment-resistant depression | 0.75 (0.2–2.76) | −0.43 | 0.667 | 2.58 (0.64–10.46) | 1.33 | 0.454 | 1.94 (0.55–6.87) | 1.03 | 0.454 |
| Anxiety | 0.9 (0.8–1.01) | −1.76 | 0.118 | 1.16 (1.01–1.33) | 2.09 | 0.111 | 1.05 (0.92–1.19) | 0.66 | 0.511 |
| Age | 1.02 (0.98–1.07) | 1.07 | 0.284 | 0.93 (0.88–0.99) | −2.48 | 0.039 | 0.96 (0.9–1.01) | −1.65 | 0.147 |
| Benzodiazepine use | 0.21 (0.06–0.73) | −2.47 | 0.039 | 1.56 (0.37–6.6) | 0.61 | 0.545 | 0.33 (0.1–1.13) | −1.76 | 0.117 |
| Depression severity | 0.98 (0.83–1.15) | −0.28 | 0.780 | 1.28 (1.07–1.52) | 2.75 | 0.009 | 1.25 (1.07–1.46) | 2.78 | 0.009 |
| Escitalopram | |||||||||
| Treatment-resistant depression | 0.64 (0.24–1.69) | −0.90 | 0.391 | 2.39 (0.87–6.59) | 1.68 | 0.279 | 1.53 (0.58–4.04) | 0.86 | 0.391 |
| Anxiety | 0.98 (0.9–1.06) | −0.56 | 0.963 | 1 (0.91–1.1) | 0.02 | 0.986 | 0.98 (0.89–1.07) | −0.46 | 0.963 |
| Age | 1.01 (0.97–1.04) | 0.34 | 0.731 | 0.97 (0.93–1.01) | −1.25 | 0.510 | 0.98 (0.94–1.02) | −0.96 | 0.510 |
| Benzodiazepine use | 1.49 (0.48–4.61) | 0.69 | 0.487 | 1.54 (0.49–4.9) | 0.74 | 0.487 | 2.3 (0.7–7.56) | 1.37 | 0.487 |
| Depression severity | 0.93 (0.82–1.06) | −1.04 | 0.297 | 1.16 (1.01–1.33) | 2.06 | 0.120 | 1.08 (0.95–1.23) | 1.15 | 0.297 |
| Placebo | |||||||||
| Treatment-resistant depression | 0.18 (0.03–0.97) | −1.99 | 0.138 | 2.05 (0.28–15.18) | 0.70 | 0.484 | 0.37 (0.06–2.16) | −1.10 | 0.404 |
| Anxiety | 0.96 (0.85–1.07) | −0.74 | 0.457 | 1.3 (1.08–1.56) | 2.83 | 0.015 | 1.24 (1.04–1.49) | 2.40 | 0.026 |
| Age | 0.98 (0.93–1.03) | −0.91 | 0.543 | 0.99 (0.92–1.06) | −0.30 | 0.767 | 0.97 (0.91–1.03) | −1.10 | 0.543 |
| Benzodiazepine use | 4.77 (0.56–40.82) | 1.43 | 0.154 | 7.05 (0.85–58.27) | 1.81 | 0.105 | 33.65 (3.98–284.23) | 3.23 | 0.003 |
| Depression severity | 0.85 (0.7–1.04) | −1.59 | 0.170 | 1.32 (1.04–1.69) | 2.24 | 0.075 | 1.12 (0.9–1.4) | 1.03 | 0.302 |
R reference category; depression severity as measured by HAM-D 17-items; boldface indicates significance after FDR correction; OR odds ratio with CI95% in parenthesis; significance of regression weights computed using Wald tests.