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PLOS One logoLink to PLOS One
. 2021 Apr 8;16(4):e0248570. doi: 10.1371/journal.pone.0248570

Perceived impact of information signals on opinions about gluten-free diets

Franklin Bailey Norwood 1,*
Editor: Camelia Delcea2
PMCID: PMC8031409  PMID: 33831038

Abstract

Understanding how people assimilate different types of information for food choices is integral to improving knowledge about diet and human health. This study evaluates the impact that 10 information signals have on the perceived healthiness of gluten. Signals include non-social signals such as personal eating experiences, scientific studies, and advice from doctors, but also includes social signals such as recommendations from attractive people, social media, the layout of a grocery store, and celebrities. An online survey of over 1,000 Americans is administered using indirect questioning where subjects are presented with a hypothetical other person and asked how the various signals would impact that person’s opinion of gluten-free diets. Results show that advice from an attractive person is thought to have a slightly larger impact than reading about a new study regarding gluten, and seeing a grocery store develop a new gluten-free section has a larger impact than learning a celebrity consumes a gluten-free diet.

Introduction

It is increasingly clear that consumers rely on more than scientific publications and medical advice to make decisions about food and health. For example, the growing popularity of gluten-free foods is hard to explain solely based on recent scientific findings or new paradigms in medical research. True, there was initially some evidence suggesting the existence of gluten-sensitivity among the non-Celiac population [1]. However, more recent evidence is mixed [25] and there is still no consensus on whether gluten sensitivity is a medical condition [6, 7]. While there is a protocol for diagnosing gluten sensitivity [8], people may self-diagnose or infer that gluten is unhealthy in ways other than irritable bowels. If gluten sensitivity exists, it is a condition in which little is understood, and affects only a small portion of the population. Certainly, the medical profession does not consider foods containing gluten to be less healthy for the general population than their gluten-free counterparts [7].

Yet, about 15% of people think they may be sensitive to gluten, and one in five think health can be improved by keeping gluten off their plates, as shown in Fig 1 below [9]. The ubiquity of ‘gluten-free’ food labels, even on foods that never contain gluten, can be seen in any grocery store, attesting to industry reports [10] that the market for gluten-free foods has risen and will continue to rise.

Fig 1. Attitudes towards gluten as held by a representative sample of U.S. citizens.

Fig 1

Source: original analysis of data reported in [9].

For a condition that is supposed to be medical in nature, gluten sensitivity has a rather strange social aspect to it, at least from popular media. It is common for politicians, movies, and television to depict gluten sensitivity as existing primarily among Americans on the political-left, yet recent research suggests it is a popular eating behavior among Trump supporters as well [9]. Survey evidence even suggests that some people consider a gluten-free diet to be a successful weight-loss strategy [11].

It only takes a moment of reflection to acknowledge that much of our beliefs about health and food do not stem from carefully vetted research and advice from medical institutions, although they obviously play an important role. Conceptual models of food choices constructed from interviews document social factors as playing an important role, and empirical studies support this claim [12, 13].

Social information signals concerning gluten’s impact on health includes personal testimonies. Such testimonies may come from friends, people we admire such as celebrities, or people who seem to take good care of their bodies. These are signals provided by specific people we encounter in our daily life. Other social signals emerge from the collective actions of many people, most of whom we do not know. Consider the layout of a grocery store. The more other people attempt to remove gluten from their diets, the more grocery stores will market towards these individuals, perhaps creating new sections catering solely to gluten-free products. This could just be stores attempting to profit from health fads, but it could also signal the fact that many other people are learning that gluten is bad for their health. Or consider the fact that January 13 is the official gluten-free day. True, there is a ‘day’ for all types of trivial matters. On July 14, you can celebrate Bastille Day, commemorating an historically important day for France. On that same day you can also celebrate National Nude Day. However silly National Nude Day may be, the fact that it exists says something about people, and the fact that there is a gluten-free day might suggest the anti-gluten movement is real and, thus, gluten may be bad for health.

What type of social information signals have the largest impact on opinions about gluten-free diets, and how does their impact compare to other signals such as a personal eating experience or a doctor’s recommendation? This is an exploratory analysis of how a variety of potential social signals may impact people’s opinions of gluten-free diets, meaning we did not design the survey experiment to test any explicit hypothesis. Rather, we sought to explore how a number of plausible signals about food and health might be interpreted. An internet survey was conducted where respondents were presented with a variety of signals and asked to predict the impact the signal would have on a hypothetical other person’s opinion of gluten-free foods. For comparison, in addition to seven social signals, three non-social signals are included: doctor recommendation, a personal eating experience, and reading about a new study concerning gluten. The next section describes the subjects who took the survey and the survey instrument. It is followed by a section on the statistical procedures employed. Then a section on the results is provided, which is followed by a description of the study’s limitations, and then a general discussion.

Materials and methods

The design and implementation of the study was evaluated and approved by the Institutional Review Board at Oklahoma State University, application AG-19-36. Explicit consent was not obtained, as consent to participate was implied if the participant chose to take the survey. Below we describe the participants recruited and the survey design.

Participants

An internet survey of Americans was conducted in the fall of 2019 using a sample acquired by the Qualtrics company, which uses an opt-in panel of respondents that ensures a representative sample of Americans in terms of key demographics like gender and ethnicity. These are respondents who are recruited to take online surveys in exchange for compensation such as gift cards, airline miles, and the like. The original sample contained 1,535 respondents. After removing those with incomplete responses, a total of 1,317 respondents remained. Descriptive statistics of the sample are shown in Table 1, as well as their counterpart statistic for the U.S. population as determined by the 2010 Census and the American Community Survey.

Table 1. Descriptive statistics of 1,317 survey respondents.

Variable Representation in Sample Representation in US Populationa
Female 50.93% 50.80%
Male 49.07% 49.20%
≤ 34 years of age 30.21% 27.38%
34 < years of age ≤ 54 37.14% 33.67%
54 < years of age 32.64% 38.95%
White ethnicity only 74.71% 76.30%
Black ethnicity only 14.43% 13.40%
Other ethnicity 10.96% 10.30%
Hispanic 17.43% 15.30%
Household income ≤ $35,000 28.07% 27.89%
$35,000 < Household income ≤ $75,000 32.36% 29.21%
$75,000 < Household income 39.57% 42.91%
Northeast region 18.36% 17.10%
Midwest region 19.07% 20.80%
South region 42.57% 38.30%
West region 20.00% 23.90%
Household has at least one unemployed member looking for work 22.64% 8.30%
Households with three or more members 50.57% 62.88%
Respondents 25 years or older with a bachelors degree 54.00% 31.50%

a Statistics for U.S. population demographics are acquired from the U.S. Census Bureau, using statistics from the 2010 Census and the American Community Survey for years 2014–2018.

A number of the demographic variables closely resemble the U.S. population and suggest a representative sample. For example, the sample is 50.93% female, which closely matches the U.S. population of 50.8% female. However, other sample demographics depart from the population, like the 54% of respondents 25 years or older in the sample with a bachelor’s degree, compared to 32% for the United States. Moreover, research has shown that samples from opt-in panels can differ from the population in a number of other features, such as the percent of households with an unemployed member looking for work [14]. Table 1 shows that 23% of the households had at least one unemployed member where, according to the American Community Survey, the percentage for a representative sample of the population during normal economic years is around 8%.

To correct for differences in the sample relative to the population, a sample balancing algorithm used by [15] is employed to calculate weights for each respondent, such that each weighted statistic for the sample in Table 1 equals the statistic for the U.S. population. For example, using these sample-balancing weights, the weighted proportion of households with three or more members equals 62.88%, equaling that of the population.

Materials

To measure the perceived impact various information signals have on people’s opinions of gluten-free diets, the survey presented respondents with a number of these signals and hypothetical other people. Subjects were then asked to indicate the impact each signal will have on the other person’s attitude towards gluten-free diets. This survey is presented in S1 Appendix. The first part of the survey concerned the demographic questions shown in Table 1. The second part contained 10 to 14 questions regarding opinions on voting, honesty, and foods that are not related to this study and are used for a separate analysis. The third part of the survey then concerned the relationship between information signals and opinions on gluten.

This third part begins by asking respondents if have heard of gluten, whether they can identify foods with gluten, and their general opinion regarding gluten. Only 4.10% of the sample said they had never heard of “gluten-free” foods, and while they are retained in the sample, a sensitivity analysis will show their inclusion has only minor impacts on the empirical results. When given a list of five foods (bread, meat, honey, tomatoes, and lettuce), and asked which are most likely to contain gluten, 82.71% of the sample correctly identified bread. When asked to choose one of four options best reflecting their opinion about gluten, 8.71% said it was unhealthy for everyone, 51.64% said it was unhealthy for some people, 11% said it was healthy for everyone, and 28.65% were unsure.

Signals

Subjects were then told they would be presented with 10 questions with each one containing a picture of a person and an event (referred to here as information signals) where the person is exposed to information regarding gluten-free diets. For each question subjects were told they would be asked how large of an impact they believe the event will have on the person’s opinion of a gluten-free diet. The type of signals, persons, and the question format is illustrated in Fig 2 below.

Fig 2. Signals, persons, and experimental design of the survey.

Fig 2

The signals chosen in Fig 2 were selected to represent both non-social and social information signals. The non-social signals were designed to reflect either personal experiences or objective sources of information. One non-social signal is personal experience (labeled personexp in Fig 2), described as experiencing irritable bowels after consuming a meal containing gluten. This is a documented reason for adopting a gluten-free diet [16]. Notice this refers to a single meal, so it represents a single personal experience and not necessarily a series of bad experiences with gluten. Objective sources of information can come from doctor recommendations or scientific studies. The doctor signal says that the person’s doctor recommends experimenting with a gluten-free diet to see if it improves health. This is not the same as a doctor saying gluten-free diets are generally healthier, only that it might be for some people. The signal referring to scientific studies (news) was described as a person reading about a new study demonstrating how some people experience irritable bowels from consuming gluten. As with the doctor signal, the news signal only says that a study shows some people might be gluten-sensitive, not that gluten is unhealthy for everyone.

The social signals are intended to represent the beliefs of certain social groups that might praise the health effects of a gluten-free diet. The signals friends, attractiveperson, and celebrity refer to influences from specific people. Friends refers to an instance where a person “has a number of friends that say good things about the gluten-free diet.” It makes sense that people who are physically attractive take good care of their bodies, including eating a healthy meal. The attractiveperson signal refers to a scenario where an attractive person met at the gym says they feel better on a gluten-free diet. Given that celebrities are thought to possess great influence, the celebrity signal refers to learning that NFL quarterback Drew Brees and actor Gwyneth Paltrow consume a gluten-free diet. These two celebrities were chosen because at least one of them should be appealing to most subjects.

The other social signals refer not to specific individuals but the collective actions of others who are likely strangers. A person might be influenced by seeing social media posts describing how people feel better on a gluten-free diet, and that is how the socialmedia signal is described. A person seeing activists argue that all foods containing gluten should be labeled as such might believe the activism is based on real health problems, so the activism signal is included as well. Walking into one’s grocery store and seeing a new display devoted solely towards gluten-free products might be viewed by some as a marketing gimmick, but others may infer from it that many others are benefitting from a gluten-free diet, so this signal (store) is included. Finally, the fact that January 13 is the official gluten-free day suggests that the diet is quite popular with many, so the signal glutenfreeday is included as well.

Hypothetical other persons

Although the goal is to measure how each of the signals would impact people’s opinions about a gluten-free diet, we deliberately avoid asking the subject how it would impact their own opinion. Instead, we ask how it would impact the opinion of a hypothetical “other” person. This is done to avoid social desirability bias, whereby a person misrepresents their true attitudes in order to appear more desirable to others. Research has shown that when you ask a person about the behavior of other people you often obtain better information about their own behavior, compared to when you directly ask them about their own behavior. For example, if you want to know whether a person would vote for a Muslim presidential candidate, you might obtain a more truthful response if you ask whether the average American would vote for one rather than if you ask if they, themselves, would. In regards to gluten, a person might be embarrassed to admit that they allow social media to influence their views, so even if social media has a larger impact on their views of gluten-free diets than their doctor’s advice, they would be reticent to admit so in a survey. Respondents would not experience the same hesitation to say so of others, however, so the indirect questioning is used to provide a more realistic depiction of the subjects’ true beliefs than if they were asked directly [1719].

Indirect questioning often asks subjects to predict the behavior of the “average American,” but it was suspected that doing so would cause the respondent to imagine a white female, as that seems to be the demographic most commonly associated with such diets in popular media. It thus seemed important to give the subject a picture of an individual to consider in the question. Then, so that the survey results as a whole do not pertain to pictures of any one particular demographic, the type of persons presented in the survey varied randomly across signals and surveys. Fig 2 shows the 11 types of persons used in the survey.

Of these persons, three are African American, four are white, two are Hispanic, one is Asian, and one is a more ambiguous ethnicity. They reflect a wide array of ages, from young to middle aged to elderly. By randomly varying the person associated with each signal, the survey ensures that the average response is not reflective of any one particular demographic; instead is a mix of the 11 persons. Subjects are asked about all 10 signals, but the order in which each signal appears in the survey is randomized.

For each signal/person combination presented, the subject is asked, “What will be the impact of this event on this person’s opinion of gluten-free diets?” The impact is measured on a 0 to 100 scale where a larger value refers to a larger projected impact. Although the impact should largely be in favor of gluten-free diets, the question does not require this; it only asks about the size of the impact, not whether it causes the person to look upon gluten-free diets more or less favorably.

Statistical procedures

Averages and sign tests

A number of different empirical procedures are used to analyze the survey results. The first includes a simple average of the impact scores. A simple average is an unbiased estimator of each signal’s importance because both the question order and the person matched with each signal is randomized. Additionally, a weighted average is performed using the weights calculated from the sample balancing algorithm to better represent the views of the U.S. population and not just the sample.

One problem with comparing average scores across signals is that different subjects may use different mental scales when answering the survey questions, making it difficult to compare a score from one person to the score of another. For example, one respondent may consider an impact score of 60 to have more or less actual impact than another person who also provides a score of 60. However, if the percentage of subjects who provide a higher score to signal A than signal B is statistically greater than 50%, one can say signal A is indeed thought to have a larger impact. As such, nonparametric sign tests, as described by a 2015 study [20], are used to determine if one signal is consistently assigned a larger impact than another signal across individuals. The null hypothesis of this test is that the median of the difference between impact scores of two signals is zero, and makes no assumption about the statistical distributions of the scores.

Regression 1

The signal impacts are also analyzed using regression analysis. The first regression models the projected impact as conditional on the signal being evaluated, the demographic profile of the respondent, and the hypothetical other person being matched with the signals. This regression is stated as follows.

Impactij=β1(activistij)+β2(celebrityij)+β3(glutenfreedayij)+β4(doctorij)+β5(friendsij)+β6(newsij)+β7(personalexpij)+β8(attractivepersonij)+β9(socialmediaij)+β10(storeij)+αZij+τPij+eij (1)

In (1), Impactij is the projected impact of the signal for the ith person on the jth question, where 0 ≤ Impactij ≤ 100. The variables activistijstoreij are indicator variables for the type of signal, and their description was given previously in Fig 2. For example, if the signal concerns the person seeing “activists arguing that all foods containing gluten should be labeled as such” then activistij = 1; otherwise activistij = 0. The vector Zij refers to indicator variables for the following demographics: (1) one indicator variable for female; (2) one variable for under 35 years of age and one variable for over 55; (3) one variable for white and one variable for black ethnicity; (4) one variable for Hispanic; (5) one variable for pretax annual household income below $30,000 and one for above $75,000; (6) one variable for northeast region, one for midwest, and one for south; (7) one variable for households with three or more members; and (8) one variable for respondents 25 years of age or older with a bachelor’s degree. As such, the default demographic is a male, without a bachelor’s degree, 35 to 54 years old, other ethnicity, non-Hispanic, in the western United States, making between $30,000 and $75,000 of household income, and in a household with less than three members.

The vector Pij refers to the hypothetical other person randomly chosen for the ith person in the jth question. Although these variables are not necessarily needed as they are randomly matched with signals in the survey, including them provides information on what types of hypothetical other people are thought to be more impacted by signals. This vector takes the form Pij = [Person2ijPerson11ij], where the identity of Person1 through Person11 is given in Fig 2, and Person2ij is an indicator variable that equals 1 if Person2 is matched with the signal and zero otherwise. As Person1 is not included in the vector, it is the default category. No intercept is included in the model so that all signal indicator variables activistijstoreij can be included. This implies that the coefficient βk should be interpreted as the average impact score for the kth signal provided by a person with the default demographic profile described previously and the default picture of Person1.

Each person answers 10 questions and, thus, the stochastic error eij should be correlated across respondents: eij~iidN(0,δi2), meaning the errors are identically and independently distributed across questions for the same person, but the errors for each person have their own fixed variance δi2. The model is estimated in STATA using ordinary least squares and the Huber and White robust estimate of variance [21, 22]. Because this model uses demographic variables as explanatory variables, sample balancing weights are not used in the estimation.

Regression 2

The second regression is the same as Regression 1 except that the demographic variables in Zij are omitted and a weighted regression is used to correct for differences in the sample and population demographics. The sample-balancing algorithm mentioned previously assigns a weight Wi to each respondent, where the weights are calibrated such that weighted averages of the sample demographics conform to the actual average of the population demographics shown in Table 1. The ordinary least squares estimation is similar to Regression 1 except that, instead of minimizing the sum of squared residuals ∑ij(eij)2, it minimizes the weighted sum of squared residuals ∑iWij(eij)2. As with Regression 1, the Huber and White robust estimate of variance [21, 22] is used to account for the panel nature of the data.

Sensitivity analysis

Three additional analyses are performed to evaluate the robustness of the results. It was previously mentioned that some respondents are less familiar with gluten than others, but the statistical analysis did not exclude anyone based on their knowledge of gluten. To investigate the impact of this decision on the results, Regression 2 is repeated twice with modifications. First, Regression 2 is estimated excluding those who say they have never heard of gluten-free foods. Second, Regression 2 is estimated excluding those who do not correctly identify which of the following foods contain gluten: bread, meat, honey, tomatoes or lettuce.

The empirical methods described previously use one number to describe the estimated impact of each signal for all respondents; however, there might be heterogeneity in the responses across respondents. As such, while one signal may seem to have a larger impact than another for the sample as a whole, this comparison may be reversed for a subset of the sample. To allow for preference heterogeneity, a latent class model is estimated. This involves estimating a version of Regressions 1 and 2, but using only the signal explanatory variables. All respondents are assumed to belong to one of two different classes, denoted c, where each class has its own unique signal coefficients βj,c. The error term is assumed normally distributed with a constant variance for each class of subjects and signal: ei,j,c~iidN(0,σj,c2). Estimates are acquired using maximum likelihood, and τc is the probability of subject i belonging to class c, which has to be estimated along with the other coefficients subject to the constraint τ1 + τ2 = 1.

Impactij=Σc=12τc(β1,c(activistij)+β2,c(celebrityij)+β3,c(glutenfreedayij)+β4,c(doctorij)+β5,c(friendsij)+β6,c(newsij)+β7,c(personalexpij)+β8,c(attractivepersonij)+β9,c(socialmediaij)+β10,c(storeij)+ei,j,c (2)

Results

Averages and sign tests: Results

Although 1,537 respondents took the survey, only the results of 1,317 are analyzed. Observations are discarded if the subject does not answer all the survey questions needed for the statistical analyses. The average impact score across all 1,317 respondents for each of the 10 signals is shown in Fig 3. A larger bar indicates a larger predicted impact. These are simple averages without sample balancing, but results for weighted averages using sample balancing weights provides virtually identical answers and, thus, are not shown. The figure also shows the results of a two-sided sign test, where any two bars with the same letter are not statistically different, meaning the null hypothesis that they possess the same median cannot be rejected at the 5% level.

Fig 3. Average impact score for information signals for 1,317 survey respondents.

Fig 3

Not surprisingly, an unpleasant personal experience consuming gluten and a doctor’s recommendation are thought to have the largest impacts on opinions about gluten-free diets. The average impact score for these two signals are in the upper 60s, meaning, on average, they are thought to have an impact between “medium” and “large.” Sign tests also indicate the average scores for these two signals are statistically different, so an unpleasant experience consuming gluten is thought to indeed have the greatest impact on opinions on a gluten-free diet of all the signals considered.

Hearing a friend or an attractive person say good things about a gluten-free diet has the third largest impact, and the average scores from these two signals are not statistically different. Both are given statistically greater scores than reading about a new study saying gluten can cause irritable bowels. Social media has the sixth largest score and is followed by a grocery store creating a new gluten-free section. The influence of activists and celebrities are not statistically different and have the least impact of any signal except for learning that January 13 is the official gluten-free day. Note that while the sign tests do detect statistical differences between most signals, the average ratings all reside in the upper- to mid-moderate range. Even the least impactful signal is thought to have a moderate impact.

Regression 1: Results

Table 2 shows the regression results from the model in (1) where impact scores are explained by the type of information signal, demographic profile of the respondent, and the hypothetical other person used. First consider the coefficients for the information signals activist … store. Each coefficient should be interpreted as the average impact score for that signal, assuming the default demographic. Each of these coefficients is roughly 4.37 units less than their respective average reported in Fig 3, so the overall results for the impact of the 10 signals are similar to the results in Fig 3.

Table 2. OLS regression using impact scores of information signals as dependent variable.

Variable Coefficient estimate Robust standard error
personalexp 70.92** 2.97
doctor 68.42** 2.96
attractiveperson 62.08** 2.95
friends 61.31** 2.96
news 60.15** 2.95
socialmedia 57.45** 2.98
store 55.98** 2.98
activist 52.73** 2.97
celebrity 50.22** 2.97
glutenfreeday 41.50** 3.01
female -3.11** 1.16
Less than 35 years of age -0.88 1.42
More than 54 years of age -2.49 1.43
White ethnicity -2.91 1.69
Black ethnicity 3.08 2.05
Hispanic 2.69 1.56
Household income > $75,000 2.67 1.41
Household income < $35,000 0.30 1.36
Northeast -0.27 1.79
Midwest 1.13 1.76
South 1.53 1.53
Household 3 or more members 3.17* 1.28
Bachelors degree -0.50 1.21
person2 1.44 2.34
person3 -0.91 2.53
person4 0.87 2.35
person5 0.17 2.57
person6 0.50 2.42
person7 -2.69 2.65
person8 -2.90 2.61
person9 1.19 2.29
person10 -1.74 2.68
person11 0.69 2.55

N = 1,317 respondents and 13,170 observations.

* Denotes statistical significance at the 5% level.

** Denotes statistical significance at the 1% level.

The statistical significance of the signal coefficients does not provide meaningful information because it only says the impact scores are different from zero. What is more interesting is whether the coefficients for different signals are statistically different from each other. Wald tests are used to test the null hypothesis that the coefficient for any one signal is equal to the coefficient of another signal, and this test is performed for every combination of two signals. The null is rejected at the 5% level for every pair of signals except for attractiverperson and friends, so as with Fig 3, hearing good things about a gluten-free diet from an attractive person or one’s friends has the same impact. All other signals have statistically different impacts.

The only statistically significant demographic variables are female and household size. From these coefficients we learn that female respondents tend to give slightly lower impact scores and households with three or more members tend to give slightly higher scores. The average differences for the impact scores between males and females, and between smaller and larger household sizes, are less than 8%, so the demographic effects are not remarkable. None of the variables referring to the hypothetical other persons are statistically significant, so while it was a priori deemed important to provide a visual description of the “other” person used in indirect questioning, a posteriori it does not appear necessary.

Regression 2: Results

The results of the weighted regression are shown below in Table 3. The second regression is similar to Regression 1 except that demographic variables are not used as demographic variables but are used instead for sample balancing. Because Regression 2 uses sample balancing weights, the regression coefficients should better reflect the beliefs of the average American as opposed to the beliefs of the average sample respondent. The interpretation of the coefficients is similar to that in Regression 1, except that the coefficients refer to the beliefs of the average American and not one particular demographic.

Table 3. OLS weighted regression using impact scores of information signals as dependent variable.

Variable Coefficient estimate Robust standard error
personalexp 71.92** 2.01
doctor 69.70** 2.01
attractiveperson 62.35** 2.01
friends 62.21** 2.01
news 60.65** 2.00
socialmedia 58.78** 2.03
store 57.21** 2.05
activist 53.04** 2.05
celebrity 51.11** 2.06
glutenfreeday 41.77** 2.13
person2 1.33 2.83
person3 -4.06 3.00
person4 -1.64 2.58
person5 -4.32 3.25
person6 -0.76 3.05
person7 -4.58 3.37
person8 -6.77* 3.28
person9 -0.61 2.72
person10 -4.73 3.65
person11 -0.07 3.08

N = 1,317 respondents and 13,170 observations.

* Denotes statistical significance at the 5% level.

** Denotes statistical significance at the 1% level.

While the coefficients for each signal differ in Regression 2 relative to Regression 1 (the average percentage difference is 13%), the overall results are similar. For example, the ranking of the signals with the highest and lowest scores are the same. The range of the signal coefficients is virtually identical as well. Wald tests (for the null hypothesis that the coefficients for any pair of signal coefficients are equal) are also identical to Regression 1, in that the only signals where the null is not rejected is for attractiveperson and friends. One difference from Regression 1 is that one of the persons variables is statistically significant. The coefficient for Person8 (see Fig 2) has a lower value than the other persons, meaning that respondents felt this young man would be less influenced by any one signal than person. All the other person variables are not statistically different from zero.

Sensitivity analysis: Results

Recall that 4.10% of the sample had never heard of gluten-free foods, so perhaps they should not be included in the analysis? To test the impact of including them, Regression 2 is estimated without these subjects, but this has virtually no impact on the results. The coefficients for any one signal changes by less than 1%, the ranking of the signal coefficients is unchanged, and the Wald tests for statistical differences between the signal coefficients are unchanged.

Another test for familiarity with gluten concerns subjects’ abilities to pick the one food containing gluten from the list: bread, meat, honey, tomato, and lettuce. If Regression 2 is estimated using only those who correctly identified “bread” as having gluten, there are some changes in the magnitude of the coefficients for the 10 signals. Most change by less than 6% but one (glutenfreeday) increases 12%. However, the ranking of the most to least influential signals is unchanged, as are the Wald tests for statistical differences between signal coefficients.

Finally, a latent class model with two classes is estimated to help detect heterogeneity in beliefs about the impacts of the information signals. This model employs an OLS regression similar to Regressions 1 and 2 except (1) no sample balancing weights are used; (2) no explanatory variables are used other than the type of signal (no demographic variables or variables describing the hypothetical other); and (3) no robust standard errors to account for the panel nature in the data, but (4) two different sets of signal coefficients for two different classes of respondents who provide different patterns of responses. As such, the signal coefficients can be interpreted as the average impact scores for each class of respondents.

The model estimates suggest that, of all the respondents, 59% belong to Class 1 and 41% belong to Class 2. The OLS signal coefficients/average impact scores for each class are shown in Fig 4. The classes differ in two distinct ways. First, Class 1 provides lower impact scores for every signal, indicating they believe each of the 10 signals will have less of an impact on other people’s opinions than Class 2. Second, Class 2 believes there will be greater heterogeneity of impacts across signals than Class 1. Except for glutenfreeday, Class 2 provides scores for all signals in the 70–80 range, whereas the range of scores for Class 1 is in the 30–60 range. Both classes agree that glutenfreeday, celebrity, and activist have the smallest impacts and doctor and personal have the largest impacts. From the latent class estimates we can conclude that the general results in the previous sections still hold true for almost half of the sample respondents. For the other half, many of the results hold true, but there are fewer differences in the impact of the signals.

Fig 4. Average impact score for information signals for 1,317 survey respondents, when respondents are separated into two classes with different survey response patterns.

Fig 4

Limitations

This study has a number of limitations which warrant acknowledgment. While the motivation for using indirect questioning has scientific justification, it would have been interesting to see how subjects would have responded if asked how they themselves would have responded to the information signals. Also, the impact of a signal was evaluated using only one type of question, whereas the results may have differed if other types were used. For example, this study allowed respondents to define a “large” or “small” impact however they liked, but different respondents may consider the same behavior to be different in terms of overall impact. Future research, including questions where a “large” impact, should be defined as “complete elimination of gluten from one’s diet” and “small” impact as “avoiding eating gluten whenever it is convenient” would be useful in interpreting the results of the study and aid in validating the questions used.

Discussion

What do these results tell us regarding the “truth” between gluten and health? We, of course, do not survey Americans in the search of an objective truth, but to better understand how consumers seek truth. Like scientists, most of our survey respondents would probably like to base their dieting behaviors on objective facts, or what philosophers call the Correspondence Theory of truth, whereby statements like “gluten is bad for you” is considered true if it corresponds to the actual state of affairs. This helps explain why respondents believe information signals like a doctor’s recommendation or a personal eating experience would have the most impact on people’s beliefs about the healthiness of gluten. Doctor recommendations are presumed to be based on scientific evidence, and while the feeling of an irritable bowel may technically be a subjective feeling, if a person feels irritable bowels that is what philosophers call first-person knowledge and there can be no ambiguity about what a person feels.

However, there is little scientific consensus on whether gluten sensitivity exists for non-Celiac patients, and no objective evidence that gluten is generally harmful to health for most people, so the decision to adopt a gluten-free diet cannot be based on the Correspondence Theory of truth. Instead, most people must rely on the Pragmatic Theory of truth, which contends “gluten is bad for you” is a true statement if it is useful—if it has value in some way to the believer [23]. There are many reasons why gluten may be deemed unhealthy in the pragmatic sense, and we explore some of these reasons below using the results of the survey.

It is sensible to take dieting advice from people similar to oneself, so the result that finds views on gluten are influenced by the eating habits of friends is intuitive. It is also sensible to take advice from people who seem to take good care of their bodies, which helps explain why equal importance is placed on the advice of attractive people and one’s friends (and why commercials use attractive people as spokespersons). While social media does often spread misleading information, it can help people communicate valuable information as well, and the fact that social media posts touting a gluten-free diet are considered to have a larger influence than celebrities and activists is telling. All of these signals can be inferences that gluten can be harmful for health, and are based on the notion that other people have had personal experiences eliminating gluten from their diets, with positive results. Likewise, for a grocery store dedicating a new section exclusively to gluten-free diets—if it works for many other people, it might work for oneself.

It is important to recognize that the belief that gluten is bad for health may be useful even if it is not true. People will change their eating habits if they adopt this belief, and those new habits may be healthier even if gluten itself is healthy. The typical American diet is high in simple carbs, low in fiber, and lacking in diversity; this is partially due to America’s high consumption of refined white flour as opposed to whole wheat flour. As one adopts a gluten-free diet, they can no longer consume wheat, rye, and barley products. So if they consume grains, they must find alternative sources such as buckwheat, teff, or quinoa. These alternative grains are more likely to be sold in whole form, containing the endosperm as well as the bran and germ. Thus, by eliminating gluten, one might be increasing one’s consumption of fiber, vitamins, and other minerals—and increasing diet diversity at the same time.

So many food products contain gluten that it can be difficult to actually achieve a gluten-free diet unless one is very careful. Following a gluten-free diet involves being more intentional regarding one’s food choices. This more serious attitude towards food and health is likely to lead to better food choices in general. It is also likely that, if one adopts a gluten-free diet in an effort to improve one’s health, they may adopt other behavioral changes, like exercising more. If the adoption of a gluten-free diet occurs concomitant with these other changes, one’s health may improve not because gluten was eliminated, but because of other reasons. Not recognizing this false association, though, people may attribute their health improvements—at least partially—to the absence of gluten. As they recommend a gluten-free diet to others, the demand for gluten-free products rise, grocery stores advertise more gluten-free products, people interpret this to mean gluten is harmful to health, so more people go gluten-free, and so on.

The point is that the belief that gluten is bad for health may be a useful belief even if it is not technically true. These beliefs are largely formed by interpreting social signals from specific people and the emergent behavior of social groups. Even seemingly insignificant signals like January 13 being the official gluten-free day is thought to have a moderate—not low—impact on beliefs about gluten. What this survey does is highlight the fact that a large number of respondents agree with the notion that beliefs about food and health stem not just from objective facts, but a variety of imperfect information signals emanating from society.

Supporting information

S1 Appendix

(DOCX)

Data Availability

Data has been submitted to DRYAD and is available at https://datadryad.org/stash/dataset/doi:10.5061/dryad.05qfttf12.

Funding Statement

Funding was made possible by the Barry Pollard MD / P&K Equipment Professorship in Agribusiness. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Decision Letter 0

Christine Mohr

2 Oct 2020

PONE-D-20-23496

Attractive people versus doctors: who knows the most about the impact of gluten on health?

PLOS ONE

Dear Dr. Norwood,

the two referees see merit, but also major issues that need to be improved. I would like to also stress the importance to properly and completely report methods and to further develop your result section. 

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Reviewer #1: Partly

Reviewer #2: Yes

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Reviewer #1: No

Reviewer #2: Yes

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Reviewer #1: The topic tackled by this paper is an interesting one. The influences that have driven the trend around gluten-free diets (outside of diagnosed celiac disease) merits scrutiny. Though I think the value of this study is really in the potential application of this approach to the communication of food related information that has the potential to positively impact people’s diets. I do however have some major concerns about the methodology and the approach to data analysis. I think for this to be publishable standard these need to be revised and I would suggest a new data analysis strategy that better reflects the design of the study and the breadth of the dataset. Finally, I think it would be worth splitting the results and discussion sections and producing a more comprehensive discussion section.

1. The title feels a bit misleading at the moment. It needs to be made clearer that actual knowledge of attractive people/ doctors was not assessed – it was actually people’s perception of how impactful others would find their knowledge.

2. The introduction would benefit from a strong set of justified hypotheses in addition to the overarching aim stated.

3. Materials and methods -should be in past tense not present tense.

4. Please provide the exact number of respondents and the exact number of useable responses at line 73 rather than an ‘over 1500’ which is fine for a summary but doesn’t make sense in the context of a methods section.

5. Please provide the rationale for the sample size. Was a power analysis conducted?

6. Where did these questions that are referred to throughout the methods section come from? Were they made up specifically for this and how was this done? Was any kind of piloting or validation work engaged in?

7. Line 81: Did you check that they put people in a frame of mind thinking of gluten? If so, how? I would remove that claim otherwise.

8. What did you do with the 4% who had never heard of gluten free foods? Eliminate or retain and why?

9. How were the ten signals developed?

10. Was the scale (small to high impact) piloted or validated in any way?

11. Where did the pictures come from? How were they selected?

12. It would be really helpful to divide the methods section into ‘participants, materials, procedure and data analysis’ sections.

13. 93-105- this would sit better in the intro section – the overall justification of approach would give more of a justified rationale in the intro section and then the methods section could be more procedural. The nuts and bolts of what happened get a bit lost in the methods section at the moment.

14. There is currently no mention of ethics in the manuscript itself that I could see.

15. I would strongly recommend the results and discussion section be split into two separate sections. At the moment the combined section is quite confusing to follow and it also feels like the two functions of the results and the discussion are not currently adequately met.

16. If there were 11 person pictures and 10 signal statements, does that mean that across the sample not everyone saw every person? Doesn’t this mess up the counterbalancing and mean that you cannot really collapse across person for your analyses?

17. Overall, the approach to analysing the data is really disappointing. I really think a more sophisticated approach should be taken and I don’t really agree with this opinion that subjectivity around the scale is a reason to NOT engage in more sophisticated (probably parametric) analyses. It is a well anchored scale and it is not a between subjects design so differences in interpretation should average out? Notwithstanding this, subjectivity around scales is something that could be discussed in a limitations section of a discussion section.

18. Connected to the last point, it really seems odd not to analyse with ‘person’ as a factor in the analysis. I would strongly recommend that the author looks into more sophisticated ways of analysing data to better reflect the design of the study. Also, it seems a shame not to have taken account of other information collected such as demographics and attitudes of gluten free diets -are their individual differences for example? Can some specific hypotheses be developed in advance of scrutinising the data in this respect?

19. Please produce a more straightforward figure depicting key results. The background and extra bits make it difficult to scrutinise from a scientific perspective – attractive though it may look!

20. It doesn’t look like there was any engagement with open science- I would add this to a limitations section in the discussion section.

21. Overall, a discussion section which takes a more critical and less descriptive approach would be welcome. Also, more sophisticated analyses would allow for a deeper consideration of the overarching scientific questions.

22. Overall, a considered limitations section would be welcome.

23. Discussion of how this approach could be used on high priority questions around the communication of dietary information might be engaged in.

Reviewer #2: 1) Is the manuscript technically sound, and does the data support the conclusions?

In places yes, in other areas it seems very brief and could be improved.

There is no detail of survey method and indirect questioning in abstract.

The introduction gives a very simplistic overview of non coeliac gluten sensitivity and the controversy around this area - this lacks depth in my opinion and needs to be improved.

There's no mention of the criteria outlined for diagnosing NCGS see

Catassi et al. (2015) Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts’ Criteria. Nutrients 7:4966-4977.

or of RCT that have found an effect from gluten - e.g.

Shahbazkhani et al (2015) Non-Celiac Gluten Sensitivity Has Narrowed the Spectrum of Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial. Nutrients (7) 4542-4554.

I am unclear if the survey had ethical approval and if participants gave consent

Or that Challenge amount used in gluten challenge is likely to be key re findings gluten challenge - This paper reports it's fructans rather than gluten but they use an amount for gluten challenge that is below what's recommended in the Catassi et al 2015 paper - so it is that surprising that they find no effect?

- Skodje GI, Sarna VK, Minelle IH, et al. Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity. Gastroenterology. 2018;154(3):529-539.e2. doi:10.1053/j.gastro.2017.10.040

Writing around weight loss @ line 49 is overly simplistic too. Excluded 'free from' diets are perceived by many to aid weight loss as they may restrict many foods that are treats and high in calories (ie. biscuits, cakes, sweets). Therefore there is evidence they are perceived as useful for weight loss.

You may find this paper a useful reference to motivations for following a gluten free diet in absence of coeliac disease.

Harper, L., Bold, J. (2018). An exploration into the motivation for gluten avoidance in the absence of coeliac disease. Gastroenterology and Hepatology from Bed to Bench 11 (3): 259-268.

More depth around responses would be useful too. E.g. Line 76-78 were responses representative geographically? Was this considered ? E.g. Rural v city areas, E / W coast versus central states?

**********

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Reviewer #1: Yes: Laura Wilkinson

Reviewer #2: No

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PLoS One. 2021 Apr 8;16(4):e0248570. doi: 10.1371/journal.pone.0248570.r002

Author response to Decision Letter 0


14 Dec 2020

I have attached a pdf document containing a letter to the editor and a Word document with my response to reviewers.

Attachment

Submitted filename: response to all reviewers.docx

Decision Letter 1

Camelia Delcea

2 Mar 2021

Perceived impact of information signals on opinions about gluten-free diets

PONE-D-20-23496R1

Dear Dr. Norwood,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Camelia Delcea

Academic Editor

PLOS ONE

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Reviewer #1: All comments have been addressed

Reviewer #3: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

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Reviewer #3: Yes

**********

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Reviewer #1: Yes

Reviewer #3: Yes

**********

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Reviewer #1: Yes

Reviewer #3: Yes

**********

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Reviewer #3: Yes

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Reviewer #1: (No Response)

Reviewer #3: The article is very relevant to the current climate where people are easily influenced by diet trends. The article provides a quantitative perspective to this issue.

The revised version of the manuscript addresses the main issues that the previous revision brought up.

**********

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Acceptance letter

Camelia Delcea

29 Mar 2021

PONE-D-20-23496R1

Perceived impact of information signals on opinions about gluten-free diets

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