Table 2.
Overview of mutants used for in vivo experiments. The deficient protein as well as the human orthologue and the proteins’ role in depression are shown.
| Mutant | Protein | Human Homologue | Role in Depression |
|---|---|---|---|
| AQ866 | Ser-4 | 5-hydroxytryptamine receptor 1A (HTR1A) |
Mutations are connected to depression and anxiety |
| DA1814 | Ser-1 | 5-hydroxytryptamine receptor 2B (HTR2B) |
agonism induces an SSRI-like response |
| DA2100 | Ser-7 | 5-hydroxytryptamine receptor 7 (HTR7) |
5-HT7 antagonism antidepressant-like effects |
| DA2109 | Ser-1/Ser-7 | HTR2B/HTR7 | See Da1814/DA2100 |
| MT9772 | Mod-5 | Serotonin transporter (SERT) |
gene-environment interaction of SERT and stress |
| RB665 | Dop-1 | Dopamine receptor D1 (D1) |
Stimulation improves depression symptoms |
| LX703 | Dop-3 | Dopamine receptor D2 (D2) |
Enhanced dopamine signalling improves symptoms |
| VC289 | Prdx-2 | Peroxiredoxin 2 (Prdx2) |
protective role in cells; oxidative stress protection |
| QV225 | Skn-1 | Nuclear factor, erythroid 2 like 2 (Nrf2) |
Lower expressions of Nrf2 correlated to depressive disorder |