. 2021 Mar 25;26(7):1844. doi: 10.3390/molecules26071844

Table 1.

Possible applications of SODs as a detoxification strategy.

Insult	Treatment Tested	Reference(s)
paracetamol hepatotoxicity	mangafodipir	[125]
	mito-tempo	[127]
	tempol	[124]
	calmangafodipir	[128] *, [129]
carbon tetrachloride intoxication	SOD2m	[133]
alcohol intoxication	SOD1	[137]
alcohol intoxication	nano-SOD	[138]
methanol intoxication	tempol	[148]
UV-induced skin damage	SODB	[139]
	SOD1	[140,141,142]
	TAT-SOD	[144]
	EUK-134	[143]
UV-induced ocular pathologies	rMnSOD	[146]
radiotherapy-induced cytotoxic response	gliadin SOD	[166,167]
	SOD	[160], [168] *
	SOD3	[165]
	GC4419	[170] *
	MnTnBuOE-2-PyP⁵⁺	[154]
	MnTDE-2-ImP⁵⁺	[157,158,159]
	MnTnHex-2-PyP⁵⁺	[155,156]
	SOD3-overexpressing MSCs	[164]
cisplatin-induced oral mucositis	GC4419	[170] *
cisplatin-induced nephrotoxicity	tempol	[175]
5-fluorouracil-induced intestinal mucositis	MS-AOE^®	[172]
Bupivacaine-induced neurotoxicity	mito-tempo	[177]

MS-AOE^® = Multi-modified Stable Anti-Oxidant Enzymes^®. SODB = Cucumis melo L.C. derived SOD, nano-SOD = SOD1 encapsulated in poly-L-lysine (PLL50)-polyethylene glycol (PEG), cross-linked with a reducible cross-linker, TAT = human immunodeficiency virus type 1 (HIV) transactivator of transcription, SOD2m = SOD2 mimetic, MSC = mesenchymal stromal cells, * clinical study.