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The effects of alkaloids on mitochondrial fusion proteins Mfn-1 (A) and Mfn-2 (B) during Dox-induced cardiotoxicity. The cells were pretreated with different concentrations of alk-A and alk-B (10, 20, and 40 µM) for 1 h, then exposed to Dox for 24 h. Relative folds of Mfn1 (C) and Mfn2 (D). Results are mean ± SEM from three independent experiments. ## p < 0.01 vs. control, * p < 0.05, ** p < 0.01 vs. Dox group, ns—no significant difference.
