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. 2021 Apr 6;26(7):2101. doi: 10.3390/molecules26072101

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of SIT on IL-6 protein expression in the adipose tissue of type-2 diabetic rats. The adipose tissue samples were dissected out from experimental rats and protein expression of IL-6 was measured by immunohistochemistry (IHC). The representative IHC photomicrographs (100× magnification) of IL-6staining intensity (arrows) in the adipose tissue samples of experimental groups are shown in this figure. (A) Normal rats; (B) type-2 diabetic rats showed elevated expression of IL-6; (C) type-2 diabetic rat treated with β-sitosterol (20 mg/kg b.wt/day orally for 30 days) showed a considerable decline in the expression of IL-6 when compared with type-2 diabetic rats and (D) type-2 diabetic rats treated with metformin (50 mg/kg, b.wt/day orally for 30 days) showed a significant reduction in the IL-6 protein expression.