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. 2021 Jan 23;144(3):963–974. doi: 10.1093/brain/awaa445

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Aged P301SxTAU62^on-off mice show lower total and soluble tau levels than their P301Shet littermates. Western blot analysis of total tau (HT7 antibody) revealed that P301Shet mice (n = 5) have a significantly higher level of total tau when compared to P301SxTAU62^on-off (abbreviated P62^on-off) mice (n = 5) at 16 months of age (A), which was confirmed by HT7/GAPDH ratio quantification (B, P = 1.32 × 10⁻⁶). Soluble tau levels (C) in P301Shet mice (n = 5) were also significantly higher than in P301SxTAU62^on-off mice (n = 5), as reflected by HT7/GAPDH ratio quantification (D, P = 0.0001). ***P < 0.001. See also Supplementary Table 2.