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. 1999 Mar 1;40(1):85–88. doi: 10.1186/BF03547044

A Case of Trisomy 22 in a Live Hereford Calf

Et tilfælde af den sjældne kromosomdefekt trisomi 22 hos en levende kalv er beskrevet. Kalven havde lavt blod-thyroxine-niveau og lav vækstrate

K Christensen 1,✉, L Juul 2
PMCID: PMC8043239  PMID: 10418199

Abstract

A case of the rare genetic trisomy 22 in a live calf is described. The calf had low blood thyroxine level and low growth rate. It had several defects including brachygnathia superior, strabismus convergence, aortal cusp insufficiency and hypertrophy of clitoris. Chromosome analysis was performed on cultured blood lymphocytes and fibroblast cells. In all counted metaphases 61 chromosomes were present. The extra chromosome was identified as a chromosome 22 by R-banding. The defects of the calf have similarities with cases of partial trisomy 3p25-pter in human. This section of the human chromosome 3 corresponds to sections of cattle chromosome 22.

Keywords: cattle, genetics, defect, congenital, Down’s Syndrome, anomaly

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References

  1. Agerholm JS, Christensen K. Trisomy 22 in a calf. J Vet. Med. 1993;40:576–581. doi: 10.1111/j.1439-0442.1993.tb00669.x. [DOI] [PubMed] [Google Scholar]
  2. Chowdhary BP, Frönicke L, Gustavsson I, Scherthan H. Comparative analysis of the cattle and human genomes: detection of ZOO-FISH and gene mapping-based chromosomal homologies. Mammalian Genome. 1996;7:297–302. doi: 10.1007/s003359900086. [DOI] [PubMed] [Google Scholar]
  3. Christensen K, Pedersen JO. Chromosome C-band polymorphism in relation to fertility in boars of the Duroc breed. Hereditas. 1990;113:183–187. doi: 10.1111/j.1601-5223.1990.tb00083.x. [DOI] [PubMed] [Google Scholar]
  4. Detrillaux B, Laurent L, Couturier J, Lejeune J. Coloration des chromosomes humaian par l’acridine orange après traitement par le bromodeoxyuridine. C.R. Acad.Sci. (Paris) 1973;278:3179–3181. [PubMed] [Google Scholar]
  5. Di Berardino D, Hayes H, Fries R, Long S. International system for cytogenetic nomenclature of domestic animals. Cytogenetic Cell Genetics. 1990;53:65–79. doi: 10.1159/000132898. [DOI] [PubMed] [Google Scholar]
  6. Herzog A, Höhn H. Über zwei weitere Fälle von Autosomaler Trisomie, 61, XY,+12 und 61,XX,+12, beim Rind. (Two cases of autosomal trisomy, 61,XY,+12 and 61,XX,+12 in cattle). Cytogenetics Cell Genetics. 1991;57:211–213. doi: 10.1159/000133149. [DOI] [PubMed] [Google Scholar]
  7. Herzog A, Höhn H, Riech GW. Survey of recent situation of chromosome pathology in different breeds of German cattle. Annal Genetics Selection Animal. 1977;9:471–491. doi: 10.1186/1297-9686-9-4-471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Herzog A, Höhn H, Olyschläger F: Autosomale Trisomie bei Kalbern mit allgemeiner Unterentwicklung (Nanismus). (Autosomal trisomy in generally underdeveloped (nanismus) calves). Deutsche Tierärztliche Wochenschrift 1982a, 89, 400–403. [PubMed]
  9. Herzog A, Höhn H, Olyschläger F, Rüsch P: 17-Trisomie beim Rind, (Trisomy 17 in cattle). Berlin und München Tierärztliche Wochenschrift 1982b, 95, 352–354. [PubMed]
  10. Kotzot D, Kruger C, Braun-Quentin C. De novo direct duplication 3(p25-pter); a previously undescribed chromosomal aberration. Clinical Genetics. 1996;50:96–98. doi: 10.1111/j.1399-0004.1996.tb02356.x. [DOI] [PubMed] [Google Scholar]
  11. König B, Tontis A, Fatzer R: Angeborene morphologische Anomalien bei Kälbern aus dem Raum Bern. (Inherited morphological anomalies in calves in Bern county). Schweitzer Archiv für Tierheilkunde 1980. 122, 435–458. [PubMed]
  12. Lilienfeld AM, Benesch CH: Epidemiology of Mongolism. The John Hopkins Press, Baltimore. 1st edition, 1969, 145 pp.
  13. Mayr B, Krutzler H, Auer H, Schleger W, Sasshofer K, Glawisching E. A viable calf with trisomy 22. Cytogenetics Cell Genetics. 1985;39:77–79. doi: 10.1159/000132109. [DOI] [PubMed] [Google Scholar]
  14. Mayr B, Schellander K, Auer H, Schleger W, Sasshofer K, Glawisching E. Offspring of a trisomic cow. Cytogenetics Cell Genetics. 1987;44:229–230. doi: 10.1159/000132376. [DOI] [PubMed] [Google Scholar]
  15. Reiss JA, Sheffield LJ, Sutherland GR. Partial trisomy 3p syndrome. Clinical Genetics. 1986;30:50–58. doi: 10.1111/j.1399-0004.1986.tb00568.x. [DOI] [PubMed] [Google Scholar]
  16. Sakai J, Ogata Y, Takahashi K, Watanabe D, Murakami R, Miyake Y, Kaneda Y. Autosomal trisomy found in a Japanese black calf with brachygnathia superior born from a dam having chromosomal translocation (in Japanese) Japan Animal Reproduction. 1991;37:185–189. doi: 10.1262/jrd1977.37.185. [DOI] [Google Scholar]
  17. Tschudi P, Ueltschi G, Martig J, Kupfer U. Autosomale Trisomie als Ursache eines hohen Ventrikelseptumdefekts bei einem Kalb der Simmentalerrasse. (Autosomal trisomy as a cause of ventricel septum defects in a Simmental-calf). Schweitzer Archiv für Tierheilkkunde. 1975;117:335–340. [PubMed] [Google Scholar]

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