Due to a production error, there was a mistake in Table 1 as published. The table was incomplete as a section inside was mistakenly omitted. The corrected Table 1 appears below. The publisher apologizes for this mistake.
TABLE 1.
Summary of the characteristics of the included trails.
| Author Year | Sample Size | Age (years) (Mean ± SD) | Gender (M/F) | Duration of psoriasis (Mean ± SD) | Intervention | Course of treatment | Adverse events | 0utcome | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E | C | E | C | E | C | E | C | E | C | E | C | |||
| Wang (2003) | 25 | 27 | 26.68 ± 12.3 | 28.62 ± 14.23 | 16/9 | 20/7 | 56.68 ± 40.23 m | 61.24 ± 39.12 m | CHM Capsule | Placebo | 4w | 4 | 0 | PASI, efficiency, AEs |
| Zhou (2011) | 235 | 115 | 38.13 ± 12.47 | 39.50 ± 13.07 | 146/89 | 74/41 | NR | NR | CHM decoction | Placebo | 8W | 10 | 2 | PASI, efficiency, AEs |
| Zhou (2012) | 35 | 27 | 34.11 ± 9.15 | 31.04 ± 7.88 | 16/19 | 11/16 | 3.97 ± 5.92 y | 3.70 ± 5.78 y | CHM decoction | Placebo | 8W | 6 | 1 | PASI, DLQI, VAS, efficiency, AEs |
| Chen (2016) | 50 | 24 | 39.5 ± 12.45 | 36.3 ± 11.38 | 36/14 | 17/7 | 15.6 ± 10.83 y | 15.2 ± 8.56y | CHM decoction | Placebo | 8W | 1 | 0 | PASI 50, PASI 60, PASI 75, AEs |
| Yao et al. (2016) | 8 | 10 | 45.43 ± 11.84 | 41.60 ± 13.24 | 7/0 | 8/2 | 144.57 ± 73.77 m | 86.20 ± 54.02 m | CHM decoction + topical sequential treatment | Placebo + topical sequential treatment | 12W | 1 | 2 | PASI50, RER, AEs |
| Li et al. (2017) | 143 | 135 | 40 ± 13 | 36 ± 12 | 78/65 | 74/61 | NR | NR | CHM Ointment | Placebo | 4W | 0 | 0 | PASI, RER, AEs |
| She (2017) | 81 | 40 | 30.12 ± 6.31 | 28.97 ± 5.03 | 41/40 | 21/19 | 11.87 ± 4.49 y | 10.94 ± 5.38 y | CHM Particle | Placebo | 12W | 2 | 1 | PASI, efficiency, AEs |
| Lv (2018) | 38 | 37 | 42.55 ± 10.86 | 38.62 ± 13.65 | 34/4 | 31/6 | 9.68 ± 6.04 y | 9.78 ± 6.31 y | CHM Particle | Placebo | 12W | 18 | 16 | PASI, PASI50, PASI 75, DLQI, VAS, RER, AEs |
| Mao et al. (2019) | 30 | 20 | 28.13 ± 9.71 | 31.50 ± 10.13 | 18/12 | 13/7 | 32.7 ± 9.3 m | 36.5 ± 8.7 m | CHM decoction | Placebo | 6W | 0 | 0 | PASI, AEs |
| Zhang (2018) | 40 | 40 | 40.73 ± 10.90 | 43.50 ± 11.75 | 33/7 | 31/9 | NR | NR | CHM Particle | Placebo | 4W | 11 | 14 | PASI, PASI50, PASI75, PASI90, DLQI, VAS, AEs |
| Li et al. (2020a) | 27 | 29 | 37.74 ± 10.50 | 41.45 ± 14.40 | 16/11 | 17/12 | NR | NR | CHM Capsule | Placebo | 4W | 6 | 1 | PASI50, PSAI75, PASI90, AEs |
| Author Year | TCM Syndrome (E/C) | Curative effect | Name of herbs | Compositions (Species, source, concentration) | Usage | Quality control reported? (Y/N) |
|---|---|---|---|---|---|---|
| Wang (2003) | NR | Clearing heat and detoxifying, removing blood stasis and removing spots, removing wind, dampness and itching | Compound Indigo Naturalis Capsules | Powder of leaves of Strobilanthes cusia (Nees) Kuntze, Whole plant of Portulaca oleracea L., Rhizome of Smilax glabra Roxb, Root bark of Dictamnus dasycarpus Turcz., Root of Angelica dahurica var. formosana (H.Boissieu) Yen, Root of Lithospermum erythrorhizon Sieb. et Zucc., Rhizome of Dryopteris crassirhizoma Nakai, Whole plant of Taraxacum mongolicum Hand-Mazz., Root and rhizome of Salvia miltiorrhiza Bunge, Root and rhizome of Dioscorea collettii var. hypoglauca (Palib.) S.J.Pei & C.T.Ting, Fruit of Prunus mume (Siebold) Siebold & Zucc., Fruit of Schisandra chinensis (Turcz.) Baill., Fruit of Crataegus pinnatifida Bunge, Massa medicata fermentata | 0.5 g*4 tid | Y-repared according to ChP Z20010157 |
| Zhou (2011) | Blood heat syndrome (78/39) | Cooling blood and detoxification | Cooling Blood and detoxification decoction | Rhizome of Smilax glabra Roxb 30g, Flower of Sophora japonica L. 15g, Root of Lithospermum erythrorhizon Sieb. et Zucc. 10g, Rhizome of Paris polyphylla 9g, Root of Rehmannia glutinosa (Gaertn.) DC. 15g, Root bark of Dictamnus dasycarpus Turcz. 10g, Root of Paeonia veitchii Lynch 10g, [Pharmacy Department of Beijing Hospital of traditional Chinese Medicine] | 100 ml bid | Y- Prepared according to ChP; Hospital preparation |
| Blood dryness syndrome (79/38) | Nourishing blood and detoxification | Nourishing Blood and detoxification decoction | Root and rhizome of Salvia miltiorrhiza Bunge 15g, Root of Angelica sinensis (Oliv.) Diels. 15g, Root of Rehmannia glutinosa (Gaertn.) DC. 15g, Root of Ophiopogon japonicus (L. f.) Ker-Gawl. 10g, Root of Scrophularia ningpoensis Hemsl. 15g, dried lianoid stem of Spatholobus suberectus Dunn 15g, Rhizome of Smilax glabra Roxb 30g, [Pharmacy Department of Beijing Hospital of Traditional Chinese Medicine] | 100 ml bid | ||
| Blood stasis syndrome (78/38) | Promoting blood circulation and detoxification | Promoting Blood Circulation and detoxification decoction | Whole grass of Hedyotis diffusa Willd. 30g, Rhizome of Curcuma zedoaria (Christm.) Roscoe 10g, Wing-shaped cork of Euonymus alatus (Thunb.) Siebold 10g, Flower of Carthamus tinctorius L. 10g, dried lianoid stem of Spatholobus suberectus Dunn 30g, Kernel of Amygdalus persica L. 10g, Root and rhizome of Salvia miltiorrhiza Bunge 15g, [Pharmacy Department of Beijing Hospital of traditional Chinese Medicine] | 100 ml bid | ||
| Zhou (2012) | Blood heat syndrome (35/27) | Cooling blood and promoting blood circulation | Liangxuehuoxue Complex Prescription | Leaf of Isatis tinctoria L. 15g, Root of Rehmannia glutinosa (Gaertn.) DC. 30g, Root of Scutellaria baicalensis Georgi 12g, Root of Lithospermum erythrorhizon Sieb. et Zucc. 9g, Root and rhizome of Salvia miltiorrhiza Bunge 12g, Root of Paeonia veitchii Lynch 6g, Root bark of Paeonia suffruticosa Andr. 9g, Root of Angelica sinensis (Oliv.) Diels. 12g, Rhizome of Smilax glabra Roxb 30g | 100 ml bid | NR |
| Chen (2016) | Blood heat syndrome (15/10) | Cooling blood and detoxification | Cooling Blood and detoxification decoction | Rhizome of Smilax glabra Roxb, Flower of Sophora japonica L., Root of Lithospermum erythrorhizon Sieb. et Zucc., Root of Rehmannia glutinosa (Gaertn.) DC., Root of Paeonia veitchii Lynch, Root bark of Paeonia suffruticosa Andr., Rhizome of Imperata cylindrica (L.) Beauv., Root bark of Dictamnus dasycarpus Turcz., Root of Saposhnikovia divaricata (Turcz. ex Ledeb.) Schischk., Whole grass of Hedyotis diffusa Willd., Rhizome of Paris polyphylla, Root of Isatis tinctoria L., [Beijing Institute of traditional Chinese Medicine] | 200 ml | Y- Prepared according to ChP; Hospital preparation |
| Blood dryness syndrome (17/5) | Nourishing blood and detoxification | Nourishing Blood and detoxification decoction | Root of Angelica sinensis (Oliv.) Diels., Root of Rehmannia glutinosa (Gaertn.) DC., Root and rhizome of Salvia miltiorrhiza Bunge, dried lianoid stem of Spatholobus suberectus Dunn, Root of Ophiopogon japonicus (L. f.) Ker-Gawl., Root of Scrophularia ningpoensis Hemsl., Root of Trichosanthes kirilowii Maxim., Rhizome of Smilax glabra Roxb, Whole grass of Hedyotis diffusa Willd., Rhizome of Paris polyphylla, Rhizome of Atractylodes lancea (Thunb.) DC., Fruit of Tribulus terrestris L., [Beijing Institute of traditional Chinese Medicine] | 200 ml | ||
| Blood stasis syndrome (4/3) | Promoting blood circulation and detoxification | Promoting Blood Circulation and detoxification decoction | Root of Angelica sinensis (Oliv.) Diels., Rhizome of Curcuma zedoaria (Christm.) Roscoe, Root and rhizome of Salvia miltiorrhiza Bunge dried lianoid stem of Spatholobus suberectus Dunn, Kernel of Amygdalus persica L., Root of Scrophularia ningpoensis Hemsl., Root and rhizome of Clematis chinensis Osbeck, Branch of Cinnamomum cassia (L.) J. Presl, Rhizome of Atractylodes lancea (Thunb.) DC., Wing-shaped cork of Euonymus alatus (Thunb.) Siebold, Whole grass of Hedyotis diffusa Willd., Rhizome of Paris polyphylla [Beijing Institute of traditional Chinese Medicine] | 200 ml | ||
| Yao et al. (2016) | NR | Promoting blood circulation, removing blood stasis and removing spots, removing wind, dampness and itching | PSORI-CM01 | Root of Paeonia veitchii Lynch, Rhizome of Curcuma zedoaria (Christm.) Roscoe, Whole plant of Sarcandra glabra (Thunb.) Nakai, Root and rhizome of Glycyrrhiza uralensis Fisch. ex DC., Fruit of Prunus mume (Siebold) Siebold & Zucc., Root of Lithospermum erythrorhizon Sieb. et Zucc., and Rhizome of Smilax glabra Roxb, [Pharmaceutical department of Chinese herbal medicine of GPHCM] | 100 ml bid | Y- Prepared according to ChP; Hospital preparation |
| Li et al. (2017) | Blood heat syndrome (143/135) | Clearing excess heat and dampness, and relieving swelling and pain. | Pulian Ointment | Powder of bark of Phellodendron amurense Rupr. 50g, Powder of root of Scutellaria baicalensis Georgi 50g and white petroleum jelly 400 g, [China-Japan Friendship Hospital] | 2 mm larger than the skin lesion area bid | Y- Prepared according to ChP; Hospital preparation |
| She (2017) | Blood dryness syndrome (44/20) | Calming the mind and relieving itching (Blood dryness) | No.1 Calm-the-Mind-and-Relieve-Itching Formula | Calcined Dragon Bone 30g, Calcined Concha Osterae (Ostrea gigas Thunberg) 30g, Concha Margaritifear (Pteria martensii (Dunker)) 30g, Calcined Magentitum 30g, Petiole charcoal of Trachycarpus fortunei (Hook). H. Wendi. 30g, Root charcoal of Sanguisorba officinalis L. 30g, Root of Angelica sinensis (Oliv.) Diels. 10g, Processing Root of Rehmannia glutinosa (Gaertn.) DC.10g, [Beijing Tcmages Pharmaceutical Co., LTD] | 200 ml bid | Y- Prepared according to ChP; Pharmacy preparation |
| Blood stasis syndrome (37/20) | Calming the mind and relieving itching (Blood stasis) | No.2 Calm-the-Mind-and-Relieve-Itching Formula | Calcined Dragon Bone 30g, Calcined Concha Osterae (Ostrea gigas Thunberg) 30g, Concha Margaritifear (Pteria martensii (Dunker)) 30g, Calcined Magentitum 30g, Petiole charcoal of Trachycarpus fortunei (Hook). H. Wendi. 30g, Root charcoal of Sanguisorba officinalis L. 30g, Rhizome of Sparganium stoloniferum (Graebn.) Buch-Ham. 10g, Rhizome of Curcuma zedoaria (Christm.) Roscoe 10g, [Beijing Tcmages Pharmaceutical Co., LTD] | 200 ml bid | ||
| Lv (2018) | NR | NR | PSORI-CM02 | Rhizome of Curcuma zedoaria (Christm.) Roscoe, Root of Paeonia veitchii Lynch, Rhizome of Smilax glabra Roxb, Whole plant of Sarcandra glabra (Thunb.) Nakai, Fruit of Prunus mume (Siebold) Siebold & Zucc. | 1 pack bid | NR |
| Mao et al. (2019) | Blood heat syndrome (30/20) | Cooling blood and promoting blood circulation | Liang xue huo xue decoction (LXHXD) | Root of Rehmannia glutinosa (Gaertn.) DC. 30 g, Flower of Sophora japonica L. 30 g, Root and rhizome of Salvia miltiorrhiza Bunge 15 g, Rhizome of Imperata cylindrica (L.) Beauv. 30 g, Root of Lithospermum erythrorhizon Sieb. et Zucc. 15 g, Root of Paeonia veitchii Lynch 15 g, and dried lianoid stem of Spatholobus suberectus Dunn 30 g. | 200 ml bid | NR |
| Zhang (2018) | Blood heat syndrome (3/4) Blood stasis syndrome (0/1) Blood dryness syndrome (37/35) | Promoting blood circulation, removing blood stasis and removing spots, removing wind, dampness and itching | PSORI-CM01 | Root of Paeonia veitchii Lynch, Rhizome of Curcuma zedoaria (Christm.) Roscoe, Whole plant of Sarcandra glabra (Thunb.) Nakai, Root and rhizome of Glycyrrhiza uralensis Fisch. ex DC, Fruit of Prunus mume (Siebold) Siebold & Zucc., Root of Lithospermum erythrorhizon Sieb. et Zucc., Rhizome of Smilax glabra Roxb, [Jiangyin Tianjiang Pharmaceutical Co., Ltd] | 5.5 g bid | Y - Prepared according to ChP; Pharmacy preparation |
| Li et al. (2020a) | NR | tonifying the kidney and removing obstruction in the channels on the blood | Kunxian capsule | Tripterygium hypoglaucum (Levl.) Hutch, Leaf of Epimedium brevicornum Maxim., Fruit of Lycium barbarum L, Seed of Cuscuta chinensis Lam., [Guangzhou chenliji Pharmaceutical Co., Ltd] | 0.3 g*2# tid | Y - Prepared according to ChP YBZ07522006 |
C, control group; E, experimental group; NR, no report; AEs, adverse events; RER, recurrence rate; DLQI, dermatology life quality index; VAS, visual analog scale; M, Male; F, Female; w, weeks; m, months; y, years.
ChP, Pharmacopoeia of the People's Republic of China; GPHCM, Guangdong Provincial Hospital of Chinese Medicine; NR, Not Remined; bid, bis in die; tid, ter in die; YBZ07522006, State food and drug administration of the People’s Republic of China, NO. YBZ07522006-2009Z.
The original article has been updated.