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Cell Death & Disease logoLink to Cell Death & Disease
. 2021 Apr 14;12(4):399. doi: 10.1038/s41419-021-03678-9

Correction: ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma

Liangsong Zhu 1,#, Rong Ding 2,#, Hao Yan 1, Jin Zhang 3,, Zongming Lin 1,
PMCID: PMC8046752  PMID: 33854032

Correction to: Cell Death and Disease

10.1038/s41419-020-2541-x published online 07 May 2020

The original version of this article unfortunately contained a mistake in Fig. 5. The correct figure can be found below. The authors apologize for the error.

Fig. 5. ZHX2 promotes ccRCC growth by transcriptional activates the MEK1/ERK1/2 signaling pathway.

Fig. 5

a The heat map of total differentialgenes in 786-O cells with LV-ZHX2 and negative control. b KEGG enrichment analysis was performed to explore the related pathways according tothe RNA-seq data. c, d The mRNA expressions of related downstream genes in MAPK/ERK1/2 pathway in 786-O/LV-ZHX2 cells. e, f The ChIP-qpcr andluciferase assays were showed ZHX2 could direct bind to the promoter of MAP2K1 in 786-O cells. g The predicted binding motif of ZHX2 in genome. h The western blot assay was used to test the protein level of MEK-ERK signal in reprogrammed 786-O and CAKI-1 cells. All experiments wererepeated double times. *p < 0.05, **p < 0.01, and ***p < 0.001.

Footnotes

Edited by B. Zhivotovsky

These authors contributed equally: Liangsong Zhu, Rong Ding

Contributor Information

Jin Zhang, Email: med-zhangjin@vip.sina.com.

Zongming Lin, Email: lin.zongming@zs-hospital.sh.cn.


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