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. 2021 Apr 1;66:103308. doi: 10.1016/j.ebiom.2021.103308

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — S. flexneri 2a LPS-Specific Serum IgM, IgG1 and IgG2. S. flexneri 2a LPS-specific serum IgM (a), IgG1 (b) and IgG2 (c) geometric mean ELISA endpoint titres grouped by vaccinated subjects with or without consensus shigellosis, and placebo subjects with or without consensus shigellosis. * = significant difference as compared to baseline titres within the same treatment group/shigellosis outcome. Significance determined by repeated measures ANOVA of log-transformed titres with Bonferroni post-hoc test. (d) Percent efficacy against consensus shigellosis post-challenge in vaccinated subjects across increasing serum IgG1 and IgG2 ELISA endpoint titres measured at time of challenge (day 56).