Table 1.

DDR1 inhibitory activity of the synthesized compounds.

Compound	Pharmacophore score[a]	Binding affinity score [kJ/mol][b]	IC50 [nM][c]
1	0.96	−50.51	1005.9
2	0.95	−52.67	2239.4
3	0.83	−47.13	92.5
4	0.96	−51.97	186.7
5	0.86	−37.29	>30,000
6	0.84	−40.83	>30,000
7	0.85	−54.38	NT[d]
8	0.85	−51.78	NT
9	0.85	−49.46	NT
7 a	0.85	−53.06	171.3
8 a	0.85	−51.15	1244.3
9 a	0.85	−54.83	1111.0

[a] Calculated using Relative Pharmacophore‐Fit score in LigandScout 4.4. [b] Calculated using iaffnity module in LigandScout 4.4. [c] The compound concentration required for 50 % inhibition (IC₅₀) was determined from semi‐logarithmic dose‐response plots, and the results represent the mean of duplicated samples. [d] NT=not tested.