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. 2021 Feb 11;217(4):iyab021. doi: 10.1093/genetics/iyab021

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© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Pol II interacts with nucleosomes genome-wide.

(A) Heatmap showing Pol II occupancies from Pol-II MNase ChIP-seq data sorted by decreasing Pol II occupancies, which were determined by ChIP-seq using sonicated chromatin.

(B) Scatterplot depicting correlation between Rpb3 ChIP-seq occupancies from MNase and sonicated chromatin.

(C)2D occupancy plots showing MPDF distribution obtained from Rpb3-bound nucleosomes for the top 10% of Pol II-occupied genes.

(D) Plot showing dyad densities for the Rpb3 (MPDFs: <130, blue trace; >130–160; red trace), MPDFs >130 for RSC (green) and nucleosomes (MNase inputs; filled blue).