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Acta Veterinaria Scandinavica logoLink to Acta Veterinaria Scandinavica
. 1998 Sep 1;39(3):331–338. doi: 10.1186/BF03547781

Rumen Motility During Induced Hyper- and Hypocalcaemia

R J Jorgensen 14,, N R Nyengaard 14, S Ham 24, J M Enemark 14, P H Andersen 34
PMCID: PMC8050694  PMID: 9787496

Abstract

Rumen motility was recorded on an experimental cow by means of telemetrie signal transfer from strain gauge force transducers fixed surgically on the peritoneal surface of the rumen wall in the left flank. The normocalcaemic cow was given a standard milk fever treatment with calcium borogluconate (400 ml with 14 mg Ca/ml) intravenously. Transient clinical signs were: decreased rumination, muscle ticks, salivation and a heart rate reduction of 20%. Rectal temperature remained unaltered. Frequency of rumen con-tractions was reduced up to 40% whereas amplitude of contractions did not deviate from baseline values. Hypocalcaemia was induced in a second experiment by iv infusion of Na2EDTA. At 0.60 mmol/1 ionized blood calcium periods of no motility were recorded whereas inactivity of rumen activity was persistent at 0.55 mmol/1 ionized blood cal-cium. The cow went down at 0.45-0.48 mmol/1 ionized blood calcium at which point the heart rate was increased by 40%. The high sensitivity of the method employed allowed the conclusion that already at a concentration of ionized blood calcium at 1.0 mmol/1 both frequency and amplitude of rumen contractions decreased rapidly although eating behaviour and rumination appeared unaffected during the short term observation peri-ods. Implications of this finding towards health and production in transition cows are discussed.

Keywords: ionized blood calcium, EDTA-infusion, telemetrie measurement

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Acknowledgments

This study was supported by the Danish Agricultural and Veterinary Research Council (grant no. 9600949).

References

  1. Ballantin HT, Herbein JH. Potentiometrie Determination of Ionized and Total Calcium in Blood Plasma of Holstein and Jersey Cows. J. Dairy Sci. 1992;74:446–449. doi: 10.3168/jds.S0022-0302(91)78190-3. [DOI] [PubMed] [Google Scholar]
  2. Bowen JM, Blackmon DM, Heavner JE. Neuromuscular transmission and Hypocalcémie Paresis in the Cow. Am. J. Vet. Res. 1970;31:831–839. [PubMed] [Google Scholar]
  3. Bueno L, Fioramonti J. Dopaminergic control of gastro-intestinal motility. In: Ruckebusch Y, Toutain P-L, Koritz GD, editors. Veterinary Pharmacology and Toxicology. Connecticut: AVI Publishing Company; 1983. pp. 283–298. [Google Scholar]
  4. Daniel RCW. Motility of the Rumen and Abomasum During Hypocalcaemia. Can. J. Comp. Med. 1983;47:276–280. [PMC free article] [PubMed] [Google Scholar]
  5. Desmecht D-M, Linden AS, Lekeux PM. Ruminai, Cardiorespiratory and Adrenocortical sequelae of Na^DTA-induced Hypocalcemia in Calves. Vet. Res. Comm. 1996;20:47–60. doi: 10.1007/BF00346577. [DOI] [PubMed] [Google Scholar]
  6. Fenvick DC, Daniel RCW. A Comparison Between the Main Clinical Signs of Milk Fever in Cows with Those of Hypocalcaemia Induced by Na^DTA Solution. J. Vet. Med. A. 1990;37:721–728. doi: 10.1111/j.1439-0442.1990.tb00965.x. [DOI] [PubMed] [Google Scholar]
  7. Goff JP, Horst RL. Calcium Salts for Treating Hypocalcemia: Carrier Effects, Acid-Base Balance, and Oral Versus Rectal Administration. J. Dairy Sci. 1994;77:1451–1456. doi: 10.3168/jds.S0022-0302(94)77083-1. [DOI] [PubMed] [Google Scholar]
  8. Hara S, Tamura T, Takahashi T, Kaneda Y, Tomizawa N, Okada N, Nishida M. Poster Presentations. Edinburgh: XIX World Buiatrics Congress; 1996. Treatment Of Left Displaced Abomasum In Dairy Cows By The Combined Use Of alfa2-Adrenergic Drugs And Rolling. [Google Scholar]
  9. Hove K, Hilde BL. Can. J. Anim. sci. 1984. Plasma calcium in the lactating cow: Dependence on continuous intestinal absorption. pp. 227–228. [Google Scholar]
  10. Huber TL, Wilson RC, Stattelman AJ, Goetsch DD. Effect of Hypocalcemia on Motility of the Ruminant Stomach. Am. J. Vet. Res. 1981;42:1488–1490. [PubMed] [Google Scholar]
  11. Itoh Z, Honda R, Takeuchi S, Aizawa I, Takayanagi R. An extraluminal force transducer for recording contractile activity of the gastrointestinal smooth muscle in conscious dogs; Its construction and implantation. Gastroent. Jpn. 1977;12:275–283. doi: 10.1007/BF02776795. [DOI] [PubMed] [Google Scholar]
  12. Kvart C, Bjorsell KA, Larsson L. Parturient paresis in the cow. Acta. vet. scand. 1982;23:184–196. doi: 10.1186/BF03546804. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Littledike ET, Glazier D, Cook HM. Electrocardio-graphic Changes After Induced Hypercalcemia and Hypocalcemia in Cattle: Reversal of the Induced Arrhytmia with Atropine. Am. J. Vet. Res. 1976;37:383–388. [PubMed] [Google Scholar]
  14. Madison JB, Troutt HF. Effects of hypocalcaemia on abomasal motility. Res. Vet. Sci. 1988;44:264–266. doi: 10.1016/S0034-5288(18)30854-3. [DOI] [PubMed] [Google Scholar]
  15. Moreau R, Squires RA. Hypercalcemia. Compend. Contin. Educ. Prate. Vet. 1992;14:1077–1081. [Google Scholar]
  16. Muir LA, Hibbs JW, Conrad HR, Smith KL. Effect Of Estrogen and Progesterone on Feed Intake and Hydroxyproline Excretion Following Induced Hypocalcemia in Dairy Cows. J. Dairy Sci. 1972;55:1613–1620. doi: 10.3168/jds.S0022-0302(72)85729-1. [DOI] [PubMed] [Google Scholar]
  17. Navarre CB, Roussel AJ. Gastrointetinal Motility and Diseases in Large Animals. Jour. Vet. Intern. Med. 1996;20:51–59. doi: 10.1111/j.1939-1676.1996.tb02027.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Radostitis OM, Blood DC, Gay CC. Veterinary Medicine; A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses. eighth. London: Bailliere Tindall; 1994. Metabolic Diseases; pp. 1310–1367. [Google Scholar]
  19. Rosol TJ, Chew DJ, Nagode LA, Capen CC. Patho-physiology of Calcium Metabolism. Vet. Clin. Patho. 1995;24:49–63. doi: 10.1111/j.1939-165X.1995.tb00937.x. [DOI] [PubMed] [Google Scholar]
  20. Smith VR, Brown WH. Response of some blood constituents to infusions of disodium ethylenediamine tetraacetate in intact cattle. J. Dairy Sci. 1963;46:223–226. doi: 10.3168/jds.S0022-0302(63)89010-4. [DOI] [Google Scholar]

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