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Journal of Multidisciplinary Healthcare logoLink to Journal of Multidisciplinary Healthcare
. 2021 Apr 12;14:799–807. doi: 10.2147/JMDH.S285044

Assessing Knowledge and Attitudes Regarding Pain Management Among Nurses Working in a Geriatric Hospital in Vietnam

Anh Trung Nguyen 1,2,, Anh Kim Dang 3, Huong Thi Thu Nguyen 1,2,4, Thanh Xuan Nguyen 1,2, Tam Ngoc Nguyen 1,2, Thu Thi Hoai Nguyen 1,2, Thang Pham 1,2, Anh Lan Nguyen 1,2, Thuy Thi Ngoc Nguyen 1, Hien Nguyen Thi 5,6, Trang Ha Nguyen 5,6, Son Hoang Nguyen 7, Bach Xuan Tran 3,8, Carl Latkin 8, Roger C M Ho 9,10, Cyrus S H Ho 11, Huyen Thi Thanh Vu 1,2
PMCID: PMC8052125  PMID: 33880029

Abstract

Background

Nurses play a pivotal role in pain management. Knowing more about nurses’ knowledge and attitudes regarding pain is important as we develop multidisciplinary pain services. Therefore, this study aimed to assess knowledge and attitudes regarding pain management among nurses in a geriatric hospital and its associated factors.

Subjects and Methods

A survey was conducted of nurses worked at the National Geriatric Hospital over a 3-month period. The Knowledge and Attitudes Survey Regarding Pain (KASRP) was utilized to assess nurses’ knowledge and attitudes toward pain management. Four domains were defined based on KASRP, included cancer-related pain, pain assessment, pharmacology and substance abuse and physical dependence. Knowledge and attitudes regarding pain were classified as poor, fair, or good (≤50%, 50% - 75%, or ≥75% of the KASRP score). Multivariate Tobit regression models were applied to identify factors associated with the knowledge and attitudes regarding pain management.

Results

Of 154 participants completed the survey, 72.2% (111 participants) had poor knowledge and attitudes regarding pain management. The participants had a correct mean score of 45.2% (SD = 2.2). Nurses’ knowledge of pain assessment was poor, with the proportion of correct answers to nine questions ranging from 2.6% to 50%. 44.8% of nurses reported never or rarely using pain assessment tools. Nurses who had previous training regarding pain at medical universities had significantly higher scores of knowledge and attitudes compared to those without training. Nurses who often use pain assessment tools had a significantly higher level of knowledge and attitudes than those who never or rarely use them.

Conclusion

This study highlights significant deficits of knowledge and negative attitudes regarding pain management among nurses. The subject of pain management should be applied and enhanced in the nursing undergraduate curriculum. Nurses’ active participation in pain management should be encouraged by healthcare providers for older patients.

Keywords: knowledge, attitude, nurse, pain management, older people

Introduction

The number of older people with pain is going to increase in Vietnam as it is due to experience one of the fastest increases in older people in the world.1,2 In 2017, Vietnam had an estimated 10 million adults aged over 65 and this is expected to rise to 19 million by 2030 and 28 million by 2050.3 Persistent pain is a common health issue among older adults, with the prevalence ranging from 45% to 80% in the community.4–6 The presence of pain and inadequate pain management is associated with the deterioration of existing health conditions, as well as functional impairment, falls, depression, decreased appetite, impaired sleep, social isolation, and low quality of life, particular in older people.7,8 It is therefore important that healthcare professionals who provide care for older people have the knowledge and skills to carefully evaluate and manage pain. Pain assessment and management of older people is complicated due to factors such as co-existing cognitive impairment, multi-morbidity, poly-pharmacy, and vulnerability to the potentially harmful adverse effects of analgesics and drug interactions.9,10

Multidisciplinary pain services provide a multidisciplinary approach to pain management. In practice, the core team consists of three types of physicians (primary care physicians, anesthesiologists, and psychiatrists) and non-physicians (psychologists, physiotherapists, and nurses). Nurses are a key member of the multidisciplinary team in healthcare facilities that specialize in providing health care to older people.11 Nurses play a pivotal role in treating pain effectively through accurate assessment, timely intervention, and the evaluation of pain relief interventions. A high level of knowledge about pain assessment and management and positive attitudes regarding pain management in nurses are considered critical factors in providing effective pain management.12,13 Previous study in the hospital setting have shown deficiencies in nurses’ knowledge of pain and pain management.14 In a study about geriatric palliative care that was not focused on pain, we found that nurses had insufficient knowledge about pain management in this specific setting.15 Apart from this study, few empirical studies have focused on nurses’ knowledge and attitudes regarding pain management in Vietnam. Thus, our study aimed to assess knowledge and attitudes regarding pain management among nurses in the National Geriatric Hospital and identify factors that influence knowledge and attitudes to pain management. The findings from this study can shed light on how the management of pain curriculum in educational courses for health staff needs to be developed.

Materials and Methods

Study Setting and Participants

A study was conducted at the National Geriatric Hospital from April to October 2018. The National Geriatric Hospital is the highest-level hospital in the system of medical examination, treatment, and health care for older people in Vietnam. All registered nurses working full-time in the clinical departments (12 departments) of the National Geriatric Hospital for at least 6 months were invited to participate in the study.

Measures and Instruments

The survey consisted of a self-administered questionnaire. Participants answered the questions by themselves in the presence of the investigator. The final version of the survey questionnaire included the following:

Socio-Economic Characteristics

Age, gender, educational level, marital status, and years of work as a nurse.

Pain management skills: whether they attended a formal or informal course on pain management, types of courses, and frequency of use of pain assessment tools on hospital wards.

Knowledge and Attitudes Survey Regarding Pain (KASRP)

The Knowledge and Attitudes Survey Regarding Pain (KASRP) was utilized to assess nurses’ knowledge and attitudes toward pain management. The KASRP was developed by Ferrell and McCaffery in 1987 and has been used frequently since then.16 The KASRP has been validated in many previous studies on medical staff and nurses of various levels of expertise, such as students, new graduates, oncology nurses, geriatric nurses, graduate students, and senior pain experts.12–14,17 The content of KASRP is derived from the current standards of pain management from the American Pain Society, the National Comprehensive Cancer Network Pain Guidelines and the World Health Organization. A panel of pain experts has established content validity. The test-retest reliability of the KASRP has been established (r > 0.8), and the internal consistency, or reliability, using Cronbach’s alpha has been measured (>0.7 in both knowledge and attitude domains).18

We applied a standardized process for developing the Vietnamese version of a subset of KASRP to use in the study. First, we conducted a forward - backward translation from English into Vietnamese involving an English translator, geriatricians, pain doctors, anesthesiologists, psychiatrists, and a representative of nurses. Any discordance emerging from the translation and reviews was discussed among the team and we produced the translated version of the tool. Secondly, we piloted this version among a small sample of 20 nurses. This pilot was to (1) assess the feasibility of using the translated tool among this group of nurses, including - administered methods, time, and flow, and (2) rapidly assess nurses’ responses to understand if there were any factors affecting the validity of the measurement, eg, understanding of the questions. Finally, we conducted a post-pilot review among the research team to finalize the Vietnamese version of the questionnaire to be applied.

The finalized version of the KASRP consisted of 39 questions, which included 22 “true or false” questions, 15 multiple-choice questions, and 2 case studies (with part a and b for each case). Each correct question was marked as 1 point. Two case studies with issues from real-world experiences of assessing and reassessing a patient were presented for which participants had to evaluate the pain of patients based on a numerical pain rating scale (0 (no pain/discomfort) to 10 (worst pain/discomfort)) and then decide on whether to prescribe intravenous (IV) morphine and if so at what dose for continued pain 2 hours after the previous IV morphine dose.

The KASRPs’ authors suggested that the analysis should avoid distinguishing items as measuring either knowledge or attitudes16 and they recommended that the scores be presented as the percentage as a percentage of correct responses. Besides calculating the total score of the KASRP, 4 domains within the tool were also defined, which were cancer-related pain (Q05, Q23, Q25, Q28, Q30), pain assessment (Q01, Q02, Q03, Q04, Q12, Q31, Q32, Q38a, Q39a), pharmacology (Q06, Q07, Q08, Q09, Q10, Q11, Q13, Q14, Q15, Q16, Q17, Q18, Q19, Q21, Q24, Q26, Q27, Q29, Q34, Q35, Q37, Q38b, Q39b), and substance abuse and physical dependence (Q20, Q22, Q33, Q36). The level of nurses’ knowledge and attitudes regarding pain was classified as follows: Poor (≤50% of the KASRP total score), Fair (50–75% of the KASRP total score), and Good (≥75% of the KASRP total score).16,19

Data Analysis

All analysis was done using STATA software version 12 (Stata Corp. LP, College Station, United States of America). Descriptive statistics for participant characteristics are presented as mean ± SD for continuous variables and frequency/percentages for categorical variables. Because the KASRP score ranges from 0 (all answers are false) to 41 (all answers are true), multivariate tobit regression models were applied to examine the factors associated with the total KASRP score. The tobit model is also called a censored regression model and aims to estimate linear relationships between variables when there is either left- or right-censoring in the dependent variable. To identify the reduced regression model, we conducted a forward stepwise selection strategy with a threshold of less than 0.2. Statistical significance was considered when p < 0.05.

Results

A total of 178 nurses initially agreed to take part in the study of whom 154 returned completed surveys to the investigator (a response rate of 86.5%). Table 1 shows the demographic characteristics of the study participants. The mean age of the participants was 29.1 years (SD=5.9) and 79.9% were female. On average participants had 5.6 years (SD = 4.4) of nursing work experience and one-third had graduated from university. Table 1 also shows the responses to the questions on pain management skills. The percentage of participants who attended a formal course on pain was 57.1%. About 66.9% and 15.6% of participants self-assessed that they had average and good skills in pain management, respectively.

Table 1.

Socio-Economic Characteristics of the Study Participants (N= 154)

Frequency (n) Percentage (%)
Gender
 Male 31 20.1
 Female 123 79.9
Marital status
 Single 92 59.7
 Married 62 40.3
Educational level
 Intermediate/Colleges 104 67.5
 University 50 32.5
Attending a formal course on pain management 88 57.1
Types of formal course
 University lectures 19 21.6
 Postgraduate training 36 40.9
 Other 33 37.5
Other sources of information on pain management 109 70.8
Types of information sources
 Books 31 20.1
 Internet 35 22.7
 Advice from expertise 20 13.0
 Training in the department 44 28.6
Using a pain assessment tool in the hospital 122 79.2
Frequency of using pain assessment tools
 Never or seldom 69 44.8
 Sometimes 61 39.6
 Usually/Everyday 24 15.6
Having experiences on pain management 60 39.0
Self-assessing of pain management skills
 Poor 27 17.5
 Average 103 66.9
 Good 24 15.6
Mean SD
Age (years) 29.1 5.9
Working experience (years) 5.6 4.4

Table 2 shows the overall KASRP knowledge and attitude results and the percentage of participants with correct responses to each KASRP question. The majority of participants were classified as having poor knowledge and negative attitudes (72.2%). The average score of percentage for the group was 45.2% (SD = 2.2). Regarding cancer-related pain, most of the nurses knew the type of analgesic medications used for prolonged pain in cancer patients (83.1%), and the analgesic medications useful for the treatment of cancer pain (63.4%). However, only 5.8% of participants had adequate knowledge about the recommended route of opioid analgesic administration for those with persistent cancer-related pain. For all the nine items in the pain assessment section, 50% or less gave a correct answer. As for the question on which of five options was the correct answer for the “the most accurate judge of the intensity of the patient’s pain”, only 25.3% of participants gave the correct answer. A low percentage of participants marked the patients’ pain rating correctly as 8 on the numerical pain scale in both case studies (20.1% and 2.6%, respectively) even though the written description mentioned that the patient “rates his pain as 8”.

Table 2.

Percentage of Nurses with Correct Responses on Each Question of the KASRP (n=154)

Frequency (n) Percentage (%)
KASRP classification
Poor knowledge and attitudes 111 72.2
Fair knowledge and attitudes 43 27.8
Item Content (correct answer) Correct (n) Accuracy (%)
Cancer related pain
25 Analgesic medications are considered for the treatment of prolonged moderate to severe pain for cancer patients (morphine)b 128 83.1
30 Useful for treatment of cancer pain (All of the above)b 97 63.4
5 Aspirin and other non-steroidal anti-inflammatory agents are NOT effective analgesics for painful bone metastases (F)a 84 54.6
28 The likelihood of the patient developing clinically significant respiratory depression in the absence of new comorbidity comorbidity (less than 1%)b 39 25.3
23 The recommended route of administration of opioid analgesics for patients with persistent cancer-related pain (oral)b 9 5.8
Pain assessment
12 Children less than 11 years old cannot reliably report pain so clinicians should rely solely on the parent’s assessment of the child’s pain intensity (F) a 77 50.0
1 Vital signs are always reliable indicators of the intensity of a patients’ pain (F)a 76 49.4
2 Because their nervous system is underdeveloped, children under two years of age have decreased pain sensitivity and limited memory of painful experiences (F)a 65 42.2
32 The best approach for cultural considerations in caring for patients in pain (Patients should be individually assessed to determine cultural influences)b 64 41.6
4 Patients may sleep in spite of severe pain (T)a 56 36.4
3 Patients who can be distracted from pain usually do not have severe pain (F)a 45 29.2
31 The most accurate judge of the intensity of the patients’ pain (the patient)b 39 25.3
39a Case study 39a (8)b 31 20.1
38b Case study 38a (8)b 4 2.6
Pharmacology
14 After an initial dose of opioid analgesic is given, subsequent doses should be adjusted in accordance with the individual patients’ response (T)a 120 77.9
7 Combining analgesics that work by different mechanisms (eg, combining an NSAID with an opioid) may result in better pain control with fewer side effects than using a single analgesic agent (T)a 113 73.4
13 Patients’ spiritual beliefs may lead them to think pain and suffering are necessary (T)a 106 68.8
21 The term “Equianalgesia” means approximately equal analgesia and is used when referring to the doses of various analgesics that provide approximately the same amount of pain relief (T)a 105 68.2
10 Elderly patients cannot tolerate opioids for pain relief (F)a 100 64.9
18 Anticonvulsant drugs such as gabapentin (Neurontin) produce optimal pain relief after a single dose (F)a 98 63.6
19 Benzodiazepines are not effective pain relievers and are rarely recommended as part of an analgesic regiment (F)a 97 63.0
24 The recommended route administration of opioid analgesics for patients with brief, severe pain of sudden onset such as trauma or postoperative pain (intravenous)b 91 59.1
29 The most likely reason a patient with pain would request increased doses of pain medication (The patient is experiencing increased pain)b 84 54.6
16 Vicodin (hydrocodone 5 mg + acetaminophen 300 mg) PO is approximately equal to 5–10 mg of morphine PO (T)a 82 53.3
6 Respiratory depression rarely occurs in patients who have been receiving stable doses of opioids over a period of months (T)a 75 48.7
34 The time to peak effect for morphine given IV (15min)b 72 46.8
27 Analgesics for post-operative pain should initially be given (around the clock on a fixed schedule)b 69 44.8
35 The time to peak effect for morphine given orally (1–2 hour)b 64 41.6
9 Opioids should not be used in patients with a history of substance Abuse (F)a 62 40.3
15 Giving patients sterile water by injection (placebo) is a useful test to determine if the pain is real (F)a 61 39.6
37 Opioid induced respiratory depression (Obstructive sleep apnea is an important risk factor)b 56 36.4
11 Patients should be encouraged to endure as much pain as possible before using an opioid (F)a 55 35.7
8 The usual duration of analgesia of 1–2 mg morphine IV is 4–5 hours (F)a 54 35.1
17 If the source of the patient’s pain is unknown, opioids should not be used during the pain evaluation period, as this could mask the ability to correctly diagnose the cause of pain (F)a 50 32.5
26 A 30 mg dose of oral morphine is approximately equivalent to (Morphine 10 mg IV)b 44 28.6
39b Case study 39b (Administer morphine 3 mg IV now)b 25 16.5
38b Case study 38b (Administer morphine 3 mg IV now)b 2 1.3
Substance abuse/physical dependence
22 Sedation assessment is recommended during opioid pain management because excessive sedation precedes opioid-induced respiratory depression (T)a 113 73.4
20 Narcotic/opioid addiction is defined as a chronic neurobiologic disease, characterized by behaviors that include one or more of the following: impaired control over drug use, compulsive use, continued use despite harm, and craving (T)a 109 70.8
33 Patients develop pain already have an alcohol and/or drug abuse problem (5–15%)b 81 52.6
36 Physical dependence is manifested by (sweating, yawning, diarrhea and agitation with patients when the opioid is abruptly discontinued)b 47 30.5

Notes: aThe item is a judgment question. T stands for right and F stands for wrong. bThe item is a single choice.

Among the pharmacology-based items, 77.9% of participants agreed that the opioid analgesic dose should be adjusted in accordance with the individual’s response after the initial dose. 73.4% knew that combining analgesics that work by different mechanisms may result in better pain with fewer side effects than using just a single agent, and 68.2% understood the meaning of the “equianalgesia” term. By contrast, only 28.6% of the participants knew the equivalent dose of a 30 mg dose of oral morphine. In the two case studies, only 16.5% and 1.3% of the participants chose the correct options about what action to take with regard to IV morphine as needed for continued pain 2 hours after a dose of IV morphine. In terms of substance abuse/physical dependence, more than 70% of the participants knew about the recommendation of assessing sedation during opioid pain management (73.4%) and the “narcotic/opioid addiction definition” (70.8%). Only 30.5% understood the signs or symptoms of physical dependence when discontinuing an opioid.

Table 3 shows the factors related to the total KASRP score. Participants who attended a formal course in pain management or obtained information via university lectures were more likely to have higher KASRP scores. In terms of pain management information sources, knowledge acquired from books, advice from experts, or training in the department was positively associated with higher KASRP scores. The use of pain assessment tools usually/everyday was also associated with higher KASRP scores.

Table 3.

Factors Associated with a Total Score of the Knowledge and Attitudes Survey Regarding Pain (KASRP)

Total Score of Knowledge and Attitudes Survey Regarding Pain
Coef 95% CI
Marital status (Ref: Single)
 Married −1.37** −2.46; −0.28
Attending a formal course on pain management (Ref: No)
 Yes 1.89*** 0.54; 3.23
Types of formal course (Ref: No)
 University lectures 2.61*** 0.76; 4.45
 Postgraduate training 1.12 −0.35; 2.61
Other sources of information on pain management (Ref: No)
 Yes 1.51** 0.26; 2.75
Types of information sources (Ref: No)
 Books 2.18*** 0.71; 3.65
 Internet 0.92 −0.37; 2.22
 Advices from experts 1.48** 0.05; 2.90
 Training in the department 1.53** 0.21; 2.85
Frequency of using pain assessment tools (Ref: Never or seldom)
 Usually/Everyday 1.91** 0.36; 3.46
Having experiences in pain management (Ref: No)
 Yes 1.93*** 0.75; 3.10
Self-assessing of your pain management skills (Ref: Poor)
 Average −0.75 −1.78; 0.28

Notes: ***p<0.01, **p<0.05.

Based on the results of the main study (154 participants), the Cronbach’s alpha for the KASRP in our study was 0.768, reflecting a high level of internal reliability.

Discussion

The main objective of our study was to evaluate the knowledge and attitudes of nurses toward pain management. The findings suggested deficient knowledge and an attitude gap about pain management among nurses working in a geriatric hospital, particularly with regard to pain assessment and the understanding of pharmacology related to pain management. Moreover, having attended formal courses on pain management, receiving information about pain management from other sources and using pain assessment tools frequently were associated with higher KASRP scores.

It is noteworthy that the overall scores from the tool we used showed that a high proportion of nurses had poor knowledge and negative attitudes regarding pain management (72.2%). Our finding is consistent with previous studies that found a deficit in nursing knowledge and negative attitudes toward pain assessment and management13,20–23 Inadequate knowledge might be the result of insufficient pain management education. This is consistent with our research findings where only 12.3% of the nurses had been trained in pain management at medical universities. This suggests that our current undergraduate nursing curriculum is not preparing nurses to systematically assess pain, make sound nursing care decisions, and use pain relievers properly and effectively. In fact, the majority of the participants were intermediate/college nurses and pain management is not included in their curriculum. Besides, this might be because of the lack of workshops or continuous education for nurses in the hospital as such courses depend on a donor resource. This finding is consistent with the findings of previous studies.23,24

The percentage of participants with correct answers for pain assessment was low. This finding may be because of nursing inexperience in pain assessment in clinical practice. The results of our study showed that 44.8% of the participants never or rarely used pain assessment tools. On the other hand, inadequate knowledge regarding pain management can be explained by the fact that nurses mainly rely on the patients’ appearance or their behaviors in assessing the pain instead of what the patients report.25 These findings are consistent with previous studies indicating that nurses tended to underestimate patients’ pain intensity and under-administer analgesics.13,20,26–28 In addition, the hospital has not had continuous pain management training for nurses, which may be one of the reasons for inadequate knowledge.

Deficits in knowledge and negative attitudes about pain medications were also found in our study. Similar to previous studies, knowledge about medications that effectively relieve the pain, the route of administration, tolerance, and side effects were mainly poor among the nurses.29,30 The participants showed better knowledge about adjusting opioid analgesics for patients after an initial dose, combining analgesics, the effectiveness of a single dose of anticonvulsant drugs, the effectiveness of benzodiazepines as pain relievers, and substance abuse/physical dependence related to the analgesic. However, we found insufficient knowledge in the areas of pharmacology (equivalent doses of analgesia, duration of the action of analgesia, types of analgesics for postoperative pain), opioid-induced respiratory depression and the doses of PRN morphine. Consistent with the finding from a previous study, a possible explanation is that our participants were not adequately trained in opioid doses, their adverse medical effects, and pharmacological knowledge.31 In Vietnam, nurses carry out physicians’ orders with regard to pain medications and are less likely to make decisions about what pain medications to give, doses, and when to give pain medications as needed. This finding is supported by the findings of Adams et al and Lewthwaite et al23,32.

Several recommendations can be drawn from this study. In this study, those who attended pain courses at medical universities, received information from books, pain experts, or training in departments, or frequently used pain assessment tools in the hospital had better knowledge and attitudes regarding pain management. This is encouraging as it suggests the provision of more education in pain management and more experience in the use of pain assessment tools can improve nurses’ knowledge and attitudes with regard to pain. If pain assessments using appropriate tools were routinely used by nurses in hospital, nurses would increase their understanding of both the physiological and behavioral responses of patients to pain.33 The findings from our study suggest that hospitals should develop interdisciplinary approaches to manage pain, with clear lines of responsibility through more nursing education, which has shown good results in previous studies.32,34,35 Hospitals as well as the Ministry of Health need to provide guidance on the assessment and treatment of pain, especially in older people. On the other hand, our study suggests that different learning methods can be used, such as books, virtual reality lectures, online material and in-service programs that are appropriate for the content being taught.36 For graduate nurses, such as those who took part in this study, there is likely to be value in conducting regular learning activities about pain assessment and management with some of form of assessment and evaluation that allows for the modification and continued refinement of the education program.37 Finally, the findings of our research could form the basis of further studies, including both quantitative and qualitative research, with larger and more representative samples of healthcare workers in Vietnam.

Our study has several limitations. The cross-sectional study design limits the ability to establish causal relationships between the factors associated with the KASRP scores. Secondly, the specific study population is a limitation on the generalization our findings. Thirdly, the KASRP was designed for general nurses and not specifically for nurses working with older people. This would require the development of a tool specifically to assess the knowledge and attitudes to pain in older people.

Conclusion

This study highlights significant deficits of knowledge and negative attitudes regarding pain management among nurses working in a geriatric hospital. It is recommended that the subject of pain and its management be applied and enhanced in continuous education and the nursing undergraduate curriculum. Nurses’ active participation in pain management should be encouraged and pain assessment tools should be routinely used by healthcare providers for older patients who report pain in clinical practice. Further studies are needed to assess the changes in knowledge and attitudes toward pain as curricular revisions are made.

Acknowledgments

We would like to express our deepest gratitude for the great support of the National Geriatric Hospital, Hanoi, Vietnam during research implementation.

Funding Statement

For the conducting process and data entry, this work was supported partly by the Hanoi Medical University fund.

Abbreviation

KASRP, Knowledge and Attitudes Survey Regarding Pain.

Data Sharing Statement

The datasets of this study are available from the corresponding author on reasonable request.

Ethics Approval and Informed Consent

The study was approved by the Ethics Committee of the National Geriatric Hospital Review Board (635/IRB-NGH) and Hanoi Medical University (63/IRB-HMU). Participants were explained clearly about the purpose of the study before participating. The purpose of the study was explained clearly to the participants before they took part. The participants had the right to not participate in or withdraw from the study at any time. Written informed consent was obtained from all participants. The questionnaire did not include any private information for or anything of harm to the participants. The results of the research were used for the study purposes only.

We confirm that our study complied with the Declaration of Helsinki.

Author Contributions

All the authors made substantial contributions to the conception and design, acquisition of data, and/or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; agreed on the journal to which the article will be submitted; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in this work.

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