Abstract
Our main goal is to develop some results for transmission of COVID-19 disease through Bats-Hosts-Reservoir-People (BHRP) mathematical model under the Caputo fractional order derivative (CFOD). In first step, the feasible region and bounded ness of the model are derived. Also, we derive the disease free equilibrium points (DFE) and basic reproductive number for the model. Next, we establish theoretical results for the considered model via fixed point theory. Further, the condition for Hyers-Ulam’s (H-U) type stability for the approximate solution is also established. Then, we compute numerical solution for the concerned model by applying the modified Euler’s method (MEM). For the demonstration of our proposed method, we provide graphical representation of the concerned results using some real values for the parameters involve in our considered model.
Keywords: Bats Corona-Virus model, Feasible region, Boundedness, Disease free equilibrium points(DFE), Theoretical results, Stability results
1. Introduction
Recently a threatful disease which is called COVID-19 another form of SARS has started to spread in globe from Wuhan a big city of China during the end of 2019. Up-to date more than 0.8 millions people all around the world have been died. Further, more than fifteen million people have been infected around the globe. According to World Health Organization (WHO) in China a medical office was identified the cases of pneumonia of unknown etiology in Wuhan City of Hubei Province of China on 31 December 2019. WHO informed that a COVID-19 was detected. Further it was declared most dangerous virus by Chinese authorities on 7 January 2020 [1], [2]. Tiamen et al. on 19 January 2020 developed a Bats-Hosts-Reservoir-People (BHRP) model for transmission from the infectious source to the human. They assumed that virus spread in the Bats population, then virus transmitted to an unknown wild animals (hosts). After hunting the hosts (defined as revivor), the virus spread in a seafood market which became cause of infection in some people. Also it has been considered that the source of COVID-19 is the transmission from animal to human. Some other researchers guaranteed that transmission also occurs from person to person. Therefore various countries implemented strict lock downed in their states and advised the public to keep social distance. Such policy have controlled the disease in some countries but this is not a permanent way to save people. Because such policies have very badly destroyed the economies of low income countries all over the world. Now, the proper vaccine has been prepared for the cure of the COVID-19.
On the other hand, bioengineers, mathematicians and researchers are also trying to make such procedure which may reduced or controlled the spreading of disease in our society further. As it is well known that mathematical models are powerful tools to study the transmission of infectious disease. Also mathematical models of infectious disease have been studied in last few decades very well [3], [4], [18], [19], [20], [21], [22], [24], [25], [27]. In this regards very recently many researchers developed various models to investigate the transmission of COVID-19. Many researcher worked on the COVID-19 model using the data for different countries [32], [33], [34], [35], [36]. Therefore, BHRP model was also built to investigate the aforesaid model. The Bats-Hosts-Reservoir-People BHRP model under classical derivative was established in [5] as
| (1) |
where people divided into five different compartments including susceptible people , exposed people , symptomatic infected people , asymptomatic infected people and removed people including recovered and removed (died) people and W represents the reservoir of virus.
It is well known fact that differential equations under CFOD having wide range of applications in various fields of science and technology [6], [7]. Therefore, in recent years, model involving CFOD have been given much attention because the biological models containing aforesaid derivative are more realistic and comprehensive as compared to the classical order models. In this regards, various aspects of the considered problems like qualitative theory, analytical and numerical solutions have been studied. For this purpose numerous techniques have been established to handle the problems. Integral transform when coupled with perturbations or decompositions techniques, we get hybrid method which have been increasingly used to handle linear and nonlinear problems of fractional order, for detail see [8], [9], [10], [11], [12], [13], [14], [15], [17], [23], [25], [26], [27], [28], [29], [30], [31]. The study of COVID-19 mathematical model under the fractional order operators is also considered in last few months. This manuscript aims to develop a mathematical model of COVID-19 with fractional order derivative to study the existence and numerical results with Wuhan’s real data. Motivated by the above work, here we considered the given form of model (1) by taking the derivative of the governing equations in fractional order. Our work is devoted some necessary research about the qualitative theory of existence of solution to the consider model though fixed point approach. Also, we derive feasibility,bounded of solution and reproduction number. Further, we established a numerical algorithm to provide graphical representation of the result to the model under consideration. We considered the COVID-19 model (1) under the CFOD with order such that as
| (2) |
with initial conditions as
| (3) |
Since it is important that to check wether a model of real problem exists or not. This thing is guaranteed by applying fixed point theory. Therefore, we establish existence theory for the considered model (2) under CFOD by fixed point theory. Here, we have established the H-U stability mostly computed for numerical results. Since, our work address numerical computation of COVID-19 model. Also, we have established the feasible region, bounded ness and reproductive number for the model. In this work, we have extended modified Euler method (MEM) to simulate the results. The concerned procedure has been used in the past for very simple nonlinear problems. Here, we have derived an algorithm to simulate our results for the considered nonlinear systems. We exhibit the results against distinct values of fractional order with graphs by using computational software like Matlab.
2. Background mmaterial
Here, in this section we recall some preliminaries from fractional calculus. For more detailed study, we refer to [6], [7], [10].
Definition 2.1
The fractional integral of Riemann–Liouville type of order of a function is defined as
provided that the integral on the right side is point-wise converges on .
Definition 2.2
The CFOD of a function f is defined by
where and represents the integer part of . Through out this paper, we use CFOD for Caputo fractional order derivatives.
Lemma 2.3
The following result holds:
for arbitrary, and, whereandrepresents the integer part of.
Definition 2.4
[16] The “generalized Taylor formula” for can be written as
(4) such that , at all . We establish MEM using (4).
Lemma 2.5
The solution of the problem for
is provided by
(5)
We represent Banach space by , where under the norm
3. Feasibility, boundedness and computation for reproductive number
Here first, we derive feasible region and bounded-ness of the model (1).
Theorem 3.1
The boundedness and feasible region of solution to the proposed model(1)is given by
(6)
Proof
Since , we have
On solving, we get
(7) where C is the constant of integration. Since from (7), one has, when ,
(8) which is our required result.
Now, we are going to compute disease free equilibrium (DFE) point and reproductive number of the model (1). For computing the equilibrium point of the model (1), we have
The disease free equilibrium point (DFE) is denoted as given as
| (9) |
Theorem 3.2
The reproduction number of the model(1)is
Proof
We take the and equations of the model (1) for finding the reproduction number. With necessary computations for the F and V matrices are given as
(10) where F is the nonlinear term and V is the linear term of the model (1). Now taking the Jacobian of the F and V matrices as
(11) Next, we have to find the generation matrix as by letting by letting and , as
(12) and
(13) Spectral radius at equation at (9), , is
(14) Hence the required result is proved. If , then the model(1) is locally asymptotically stable (out break will go to end). If , then the model (1) is unstable(outbreak will spread).
4. Theoretical results for model (2)
The existence of solution to a physical problem is verified by using fixed point approach. We use the theorem published in [14], [15] to derive the intended results. The right sides of model (2) can be expressed as:
| (15) |
| (16) |
In view of Lemma 2.5, (16) yields
| (17) |
where . To derive required results, some assumptions need to be hold:
- () There exists constant , such that for each with
- () There exists constants and , such that
Theorem 4.1
Let Y be the Banach space andbe the convex and compact subset, then there exist operator, which has at least one fixed point.
Proof
Considered a compact and closed set denoted by . Also define an operator as
(18) To show the operator in (18) is contraction, let , we have
From which we have
Which shows that is contraction if .
Next show that is compact and continuous operator. To get this goal, consider
(19) Hence is bounded in (19). Let , one has
(20) Since if , then right side of (20) goes to zero. Hence , led us that
Hence is equi-continuous, so is compact continuous. Therefore is completely continues operator. Thus all the condition of Theorem 4.1 are satisfied so the model (2) has at least one solution.
Theorem 4.2
Under the continuity of, for, and if the conditionholds, then the system(2)has a unique solution.
Proof
Let , be the operator defined by
(21) Let , then we have
Hence the model has unique solution by using Banach contraction theorem.
5. H-U stability
Here, we derive H-U type stability for (16), which lead us to the stability of system (2). Consider a small perturbation with .
Lemma 5.1
The perturbed problem
(22) solution obeys
(23)
Proof
The proof is easy.
Theorem 5.2
Under hypothesis() together with result(23)inLemma 5.1, the solution of the integral Eq.(17)is H-U stable and consequently, the numerical results of the considered system are H-U stable if.
Proof
Let be a unique solution and be any solution of (17), then
(24) From which we have
(25) From (25), we can write
(26) Hence the required results about H-U stability.
6. Numerical algorithm and discussion
In this part of the paper, we have to evaluate approximate solutions of the model (2) under CFOD. Then the numerical simulations are acquired via the suggested scheme. To this aim, we employ the CFOD to establish a numerical procedure for the simulation of our considered model (2).
6.1. General algorithm
Here, we extend the numerical method of Euler for our considered model (2). The aforesaid considered model can be written as
| (27) |
Let be the interval of solution for (27). We subdivide the intervalinto j subintervals with uniform width via using the nodes , for . Let
up to higher order are continuous on . Applying the MEM about to the considered model expressed in (27) and for each value t take value a, the expression for , one has
| (28) |
Let the step size h is chosen small enough, then we may neglect the second-order term involving and get the results from (28) as
| (29) |
Proceeding on aforesaid fashion, a general formula at is established as
| (30) |
where .
6.2. Numerical interpretation
Here in this subsection, graphical interpretation of numerical results to the concerned model is given. For this aim, we use the adopted scheme for the numerical simulation. Here, we choose some appropriate values for the parameters used in the model that is given in the Table 1 (see [28]). Graphical presentations are given in Figures , for various values of . We construct an algorithm to simulate the results by using Matlab in Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6 .
Table 1.
Description of the parameters involve in the model (2).
| Parameters | Description of Parameters | |||||
|---|---|---|---|---|---|---|
| Susceptible people | ||||||
| Exposed people | ||||||
| Infected people | ||||||
| Asymptomatic people | ||||||
| Recovered people | ||||||
| Resivior | ||||||
| Rate of death | ||||||
| Total population and birth rate | ||||||
| Incubation period | ||||||
| Latent period | ||||||
| Infectious period of symptomatic infection | ||||||
| Infectious period of asymptomatic infection of people | ||||||
| Transmission rate from to | ||||||
| Transmission rate fromWto | ||||||
| Shedding coefficients from to W | ||||||
| Shedding coefficients from to W | ||||||
| Proportion of asymptomatic infection rate of people | ||||||
| Multiple of the transmissibility of to that of | ||||||
| Lifetime of the virus in W |
Fig. 1.
Graph of approximate solution for susceptible class at different fractional values of .
Fig. 2.
Graph of approximate solution for exposed class at different fractional values of .
Fig. 3.
Graph of approximate solution for symptomatic infected class at different fractional values of .
Fig. 4.
Graph of approximate solution for asymptomatic infected class at different fractional values of .
Fig. 5.
Graph of approximate solution for recovered people at different fractional values of .
Fig. 6.
Graph of approximate solution for reservoir class at different fractional values of .
In Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6 we have presented the plot for the different compartments of the considered model corresponding to various fractional values order . We have presented the numerical results for initial 200 days. Initially the infection in first month that first thirty days was increasingly transmitted but on time control the China government implemented strict precautionary measures which controlled the disease very well in coming two months. In Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, we have given the evolution of COVID-19 in Wuhan city for initial 200 days. Further, From the Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, one can observe that the considered model extremely depends on the order and offers more degree of flexibility. As we increase the values of the , we see that the solution tends to integers order solution. The growing and decaying rate of various classes of model is different at different fractional order. Therefore fractional calculus can be helpful in understanding the transmission dynamics of COVID-19. Here we, remark that at smaller fractional order the decay process is faster while the growth rate is slow. Increasing the fractional order the process of decay may become slow while,the grow rate goes on raising. Further, the fractional order has great impact on the transmission dynamics of the proposed model. Also, it helps in better understanding of physical behaviour of spreading of infection in a community. Moreover, the adopted numerical method can be used as a fruitful technique to achieve computational results for such type nonlinear problems. The concerned growth or decay process of various compartments is faster slightly at lower fractional order as compared to greater value of .
7. Conclusion
We have established some qualitative results for the mathematical model (2) involving CFOD. Using the nonlinear analysis, we have derived feasibility of the solution and bounded ness of the result to the concerned model. Also, we derived the reproductive number for the model under study. For the needed results about existence and uniqueness of solution fixed point theory has been used. Also we have developed the Ullam-Hyers stability results for the considered model. Further, we have computed numerical solutions for the considered model via a powerful technique due to Euler. Graphical representations have been given to check the dynamical behavior of solution by using Matlab. We have computed the results regarding to distinct values of fractional orders. The gained results play crucial part in showing the theory of fractional analytical dynamic for the existing outbreak due to COVID −19 which has badly affected the entire globe. From the computations we observed that the increase or decrease in different compartments is faster at higher fractional order of the derivative and we see that fractional calculus has the ability to explain the papulation dynamics more comprehensively. The presented results may be fruitful for the existing outbreak in a better way and can be used in taking defensive techniques to decrease the infection. In future the proposed scheme can be utilized to investigate more nonlinear problems of FODEs involving CFOD.
Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Acknowledgement
We are thankful to the reviewers for their useful suggestions.
Footnotes
Peer review under responsibility of Faculty of Engineering, Alexandria University.
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