Skip to main content
Elsevier - PMC COVID-19 Collection logoLink to Elsevier - PMC COVID-19 Collection
. 2021 Apr 18;60(6):5287–5296. doi: 10.1016/j.aej.2021.04.032

Study of COVID-19 mathematical model of fractional order via modified Euler method

Ghazala Nazir a, Anwar Zeb b,, Kamal Shah a, Tareq Saeed c, Rahmat Ali Khan a, Sheikh Irfan Ullah Khan b
PMCID: PMC8053243

Abstract

Our main goal is to develop some results for transmission of COVID-19 disease through Bats-Hosts-Reservoir-People (BHRP) mathematical model under the Caputo fractional order derivative (CFOD). In first step, the feasible region and bounded ness of the model are derived. Also, we derive the disease free equilibrium points (DFE) and basic reproductive number for the model. Next, we establish theoretical results for the considered model via fixed point theory. Further, the condition for Hyers-Ulam’s (H-U) type stability for the approximate solution is also established. Then, we compute numerical solution for the concerned model by applying the modified Euler’s method (MEM). For the demonstration of our proposed method, we provide graphical representation of the concerned results using some real values for the parameters involve in our considered model.

Keywords: Bats Corona-Virus model, Feasible region, Boundedness, Disease free equilibrium points(DFE), Theoretical results, Stability results

1. Introduction

Recently a threatful disease which is called COVID-19 another form of SARS has started to spread in globe from Wuhan a big city of China during the end of 2019. Up-to date more than 0.8 millions people all around the world have been died. Further, more than fifteen million people have been infected around the globe. According to World Health Organization (WHO) in China a medical office was identified the cases of pneumonia of unknown etiology in Wuhan City of Hubei Province of China on 31 December 2019. WHO informed that a COVID-19 was detected. Further it was declared most dangerous virus by Chinese authorities on 7 January 2020 [1], [2]. Tiamen et al. on 19 January 2020 developed a Bats-Hosts-Reservoir-People (BHRP) model for transmission from the infectious source to the human. They assumed that virus spread in the Bats population, then virus transmitted to an unknown wild animals (hosts). After hunting the hosts (defined as revivor), the virus spread in a seafood market which became cause of infection in some people. Also it has been considered that the source of COVID-19 is the transmission from animal to human. Some other researchers guaranteed that transmission also occurs from person to person. Therefore various countries implemented strict lock downed in their states and advised the public to keep social distance. Such policy have controlled the disease in some countries but this is not a permanent way to save people. Because such policies have very badly destroyed the economies of low income countries all over the world. Now, the proper vaccine has been prepared for the cure of the COVID-19.

On the other hand, bioengineers, mathematicians and researchers are also trying to make such procedure which may reduced or controlled the spreading of disease in our society further. As it is well known that mathematical models are powerful tools to study the transmission of infectious disease. Also mathematical models of infectious disease have been studied in last few decades very well [3], [4], [18], [19], [20], [21], [22], [24], [25], [27]. In this regards very recently many researchers developed various models to investigate the transmission of COVID-19. Many researcher worked on the COVID-19 model using the data for different countries [32], [33], [34], [35], [36]. Therefore, BHRP model was also built to investigate the aforesaid model. The Bats-Hosts-Reservoir-People BHRP model under classical derivative was established in [5] as

dSpdt=Λp-mpSp-βpSp(Ip+kAp)-βWSpW,dEpdt=βpSp(Ip+kAp)+βWSpW-(1-δp)ωpEp-δpωp´Ep-mpEp,dIpdt=(1-δp)ωpEp-(γp+mp)Ip,dApdt=δpωp´Ep-(γ´p+mp)Ap,dRpdt=γpIp+γP´Ap-mpRp,dWdt=μpIp+μ´pAp-εW, (1)

where people divided into five different compartments including susceptible people Sp, exposed people Ep, symptomatic infected people Ip, asymptomatic infected people Ap and removed people Rp including recovered and removed (died) people and W represents the reservoir of virus.

It is well known fact that differential equations under CFOD having wide range of applications in various fields of science and technology [6], [7]. Therefore, in recent years, model involving CFOD have been given much attention because the biological models containing aforesaid derivative are more realistic and comprehensive as compared to the classical order models. In this regards, various aspects of the considered problems like qualitative theory, analytical and numerical solutions have been studied. For this purpose numerous techniques have been established to handle the problems. Integral transform when coupled with perturbations or decompositions techniques, we get hybrid method which have been increasingly used to handle linear and nonlinear problems of fractional order, for detail see [8], [9], [10], [11], [12], [13], [14], [15], [17], [23], [25], [26], [27], [28], [29], [30], [31]. The study of COVID-19 mathematical model under the fractional order operators is also considered in last few months. This manuscript aims to develop a mathematical model of COVID-19 with fractional order derivative to study the existence and numerical results with Wuhan’s real data. Motivated by the above work, here we considered the given form of model (1) by taking the derivative of the governing equations in fractional order. Our work is devoted some necessary research about the qualitative theory of existence of solution to the consider model though fixed point approach. Also, we derive feasibility,bounded of solution and reproduction number. Further, we established a numerical algorithm to provide graphical representation of the result to the model under consideration. We considered the COVID-19 model (1) under the CFOD with order η such that 0<η1 as

cDηSp(t)=Λp-mpSp-βpSp(Ip+kAp)-βWSPW,cDηEp(t)=βpSp(Ip+kAp)+βWSpW-(1-δp)ωpEp-δpωp´Ep-mpEp,cDηIp(t)=(1-δp)ωpEp-(γp+mp)Ip,cDηAp(t)=δpωp´Ep-(γ´p+mp)Ap,cDηRp(t)=γpIp+γp´Ap-mpRp,cDηW(t)=μpIp+μ´pAp-εW, (2)

with initial conditions as

Sp(0)=Sp0,Ep(0)=Ep0,Ip(0)=Ip0,Ap(0)=Ap0,Rp(0)=Rp0,W(0)=W0. (3)

Since it is important that to check wether a model of real problem exists or not. This thing is guaranteed by applying fixed point theory. Therefore, we establish existence theory for the considered model (2) under CFOD by fixed point theory. Here, we have established the H-U stability mostly computed for numerical results. Since, our work address numerical computation of COVID-19 model. Also, we have established the feasible region, bounded ness and reproductive number for the model. In this work, we have extended modified Euler method (MEM) to simulate the results. The concerned procedure has been used in the past for very simple nonlinear problems. Here, we have derived an algorithm to simulate our results for the considered nonlinear systems. We exhibit the results against distinct values of fractional order with graphs by using computational software like Matlab.

2. Background mmaterial

Here, in this section we recall some preliminaries from fractional calculus. For more detailed study, we refer to [6], [7], [10].

Definition 2.1

The fractional integral of Riemann–Liouville type of order ηR+ of a function fL1([0,),R) is defined as

Iηf(t)=1Γ(η)0t(t-ξ)η-1f(ξ)dξ,

provided that the integral on the right side is point-wise converges on (0,).

Definition 2.2

The CFOD of a function f is defined by

cDηf(t)=1Γ(m-η)0t(t-ξ)m-η-1f(n)(ξ)dξ,

where m=[η]+1 and [η] represents the integer part of η. Through out this paper, we use CFOD for Caputo fractional order derivatives.

Lemma 2.3

The following result holds:

Iη[cDηf](t)=f(t)+a0+a1t+a2t2++am-1tm-1,

for arbitraryaiR, andi=0,1,2,,m-1, wherem=[η]+1and[η]represents the integer part ofη.

Definition 2.4

[16] The “generalized Taylor formula” for f(t) can be written as

f(t)=i=0mtiηΓ(iη+1)Diηf(0)+Dτ(m+1)ηf(ξ)Γ((m+1)η+1), (4)

such that ξ[0,t], at all t(0,a],η(0,1]. We establish MEM using (4).

Lemma 2.5

The solution of the problem for0<η1

cDηϕ(t)=g(t),t[0,T]=J,ϕ(0)=ϕ0,

is provided by

ϕ(t)=ϕ0+1Γ(η)0t(t-ξ)η-1g(ξ)dξ. (5)

We represent Banach space by Z=Y×Y×Y×Y×Y×Y, where Y=C(J),0tT< under the norm

V=(Sp,Ep,Ip,Ap,Rp,W)=maxtJ[|Sp(t)|+|Ep(t)|+|Ip(t)|+|Ap(t)|+|Rp(t)|+|W(t)|].

3. Feasibility, boundedness and computation for reproductive number

Here first, we derive feasible region and bounded-ness of the model (1).

Theorem 3.1

The boundedness and feasible region of solution to the proposed model(1)is given by

Γ=(Sp,Ep,Ip,Ap,Rp,W)R+6:0V(t)Λp(+γp+γp´+(mp+μp+μp´)). (6)

Proof

Since V(t)=(Sp(t)+Ep(t)+Ip(t)+Ap(t)+Rp(t)+W(t)), we have

dVdt=dSPdt+dEpdt+dIpdt+dApdt+dRpdt+dWdt,=Λp+mpSp-Spωp´Ep-mpEp-(γp+mp)Ip+δpωp´Ep-(γp´+mp)Ap+γpIP+γp´Ap-mpRp+μpIp+μp´AP-W,=Λp-mp(Sp+Ep+Ip+Ap+Rp)-γpIp-γp´Ap+γp´Ap+μpIp+μp´Ap-W,dVdtΛp-mpV+(mp-)W+μpIp+μp´Ap,Λp+(mp-)V+μpV+μ´V,Λp-(+μp)-(mp+μ´)V,dVdt+(+μp)-(mp+μp´)VΛp.

On solving, we get

V(t)Λp(+μp)-(mp+μp´)+Ce-[(+μp)-(mp+μp´)]t, (7)

where C is the constant of integration. Since from (7), one has, when t,

V(t)Λp(+μp)-(mp+μp´), (8)

which is our required result.

Now, we are going to compute disease free equilibrium (DFE) point and reproductive number of the model (1). For computing the equilibrium point of the model (1), we have

dSpdt=dEpdt=dIpdt=dApdt=dRpdt=dWdt=0.

The disease free equilibrium point (DFE) is denoted as θ=(Sp0,Ep0,Ip0,Ap0,Rp0,W0) given as

θ=(Λpmp,0,0,0,0,0). (9)

Theorem 3.2

The reproduction number of the model(1)is

R0=βpΛp-1-δpωp+βwΛpμp-1-δpωpmp1-δpωp+δpωp´-mpγp+mp.

Proof

We take the 2nd,3rd and 6th equations of the model (1) for finding the reproduction number. With necessary computations for the F and V matrices are given as

F=βpSp(Ip+kAp)+βwSpW00,V=(1-δp)ωpEp+δpωp´Ep+mpEp-(1-δp)ωpEp+(γp+mp)Ip-μpIp-μp´Ap-W, (10)

where F is the nonlinear term and V is the linear term of the model (1). Now taking the Jacobian of the F and V matrices as

F=0βpSpβwSp000000,V=1-δpωp+δpωp´+mp00-1-δpωpγp+mp00-μp. (11)

Next, we have to find the generation matrix as FV-1 by letting by letting a=1-δpωp+δpωp´+mp,b=-1-δpωp and c=(γp+mp), as

V-1=1a00-(1-δp)ωp(γp+mp)00-μp, (12)

and

FV-1=βpSpbac-βpSpμpbacβpSpc+βwSpμpcβwSp000000. (13)

Spectral radius at equation at (9), θ=(Λpmp,0,0,0,0,0), is

ϱ(FV-1)=-βpSpbac-βwSpμpbac,R0=-βpΛpmpbac-βwΛpmpμpbac,=-βpΛpbmpac-βwΛpμpbmpac,=-βpΛp(-(1-δp)ωp)mp((1-δp)ωp+δpωp´-mp)(γp+mp)-βwΛpμp(-(1-δp)ωp)mp((1-δp)ωp+δpωp´-mp)(γp+mp),R0=βpΛp(-(1-δp)ωp)+βwΛpμp(-(1-δp)ωp)mp((1-δp)ωp+δpωp´-mp)(γp+mp). (14)

Hence the required result is proved. If R0<1 , then the model(1) is locally asymptotically stable (out break will go to end). If R0>1, then the model (1) is unstable(outbreak will spread).

4. Theoretical results for model (2)

The existence of solution to a physical problem is verified by using fixed point approach. We use the theorem published in [14], [15] to derive the intended results. The right sides of model (2) can be expressed as:

Θ1=Λp-mpSp-βpSp(Ip+kAp)-βWSPW,Θ2=βpSp(Ip+kAp)+βWSpW-(1-δp)ωpEp-δpωp´Ep-mpEp,Θ3=(1-δp)ωpEp-(γp+mp)Ip,Θ4=δpωp´Ep-(γ´p+mp)Ap,Θ5=γpIp+γp´Ap-mpRp,Θ6=μpIp+μ´pAp-εW. (15)

Using (15), model (2) becomes

cDηV(t)=Ψ(t,V(t)),0<η1,V(0)=V0. (16)

In view of Lemma 2.5, (16) yields

V(t)=V0(t)+1Γ(η)0t(t-ξ)η-1Ψ(ξ,V(ξ))dξ, (17)

where V(t)=Sp(t)Ep(t)Ip(t)Ap(t)Rp(t)W(t),V0(t)=Sp0Ep0Ip0Ap0Rp0W0,Ψ(t,V(t))=Θ1Θ2Θ3Θ4Θ5Θ6. To derive required results, some assumptions need to be hold:

  • (A1) There exists constant KΨ>0, such that for each V(t),V(t) with
    |Ψ(t,V(t))-Ψ(t,V(t))|=KΨ|V(t)-V(t)|;
  • (A2) There exists constants CΨ>0 and MΨ>0, such that
    |Ψ(t,V(t))|=CΨ|V|+MΨ.

Theorem 4.1

Let Y be the Banach space andΩYbe the convex and compact subset, then there exist operatorS:ΩΩ, which has at least one fixed point.

Proof

Considered a compact and closed set Ω denoted by Ω={VY:Vr}. Also define an operator as

S(V(t))=V0+1Γ(η)0t(t-ξ)η-1Ψ(ξ,V(ξ))dξ. (18)

To show the operator S in (18) is contraction, let V,VY, we have

S(V)-S(V)=|SV(t)-SV(t)|,=|1Γ(η)0t(t-ξ)η-1Ψ(ξ,V)-1Γ(η)0t(t-ξ)η-1Ψ(ξ,V)|dξ,=1Γ(η)0t(t-ξ)η-1|Ψ(ξ,V)-Ψ(ξ,V)|dξ.

From which we have

S(V)-S(V)1Γ(η+1)KΨV-V.

Which shows that S is contraction if KΨ<1.

Next show that S is compact and continuous operator. To get this goal, consider

|SV(t)|=|V0+1Γ(η)0t(t-ξ)η-1Ψ(ξ,V(ξ))dξ|,|V0|+1Γ(η)0t(t-ξ)η-1|Ψ(ξ,V(ξ))|dξ,SV|V0|+1Γ(η)0t(t-ξ)η-1|Ψ(ξ,V(ξ))|dξ,|V0|+1Γ(η+1)[CΨVq1+MΨ]. (19)

Hence S is bounded in (19). Let t1<t2J, one has

|SV(t2)-SV(t1)|=|1Γ(η)0t2(t2-ξ)η-1Ψ(ξ,V)dξ-1Γ(η)0t1(t1-ξ)η-1Ψ(ξ,V)dξ|,1Γ(η)0t1(t2-ξ)η-1-(t1-ξ)η-1|Ψ(ξ,V)|dξ+1Γ(η)t1t2(t2-ξ)η-1|Ψ(ξ,V)|dξ,1Γ(η+1)[CΨV+MΨ]t1η-t2η+(t1-t2)η+(t2-t1)η. (20)

Since if t2t1, then right side of (20) goes to zero. Hence t2t1, led us that

|SV(t2)-SV(t1)|0.

Hence S is equi-continuous, so S is compact continuous. Therefore S is completely continues operator. Thus all the condition of Theorem 4.1 are satisfied so the model (2) has at least one solution.

Theorem 4.2

Under the continuity ofΘi, fori=1,2,3,4,5,6, and if the conditionKΨΓ(η+1)<1holds, then the system(2)has a unique solution.

Proof

Let S:YY, be the operator defined by

S(V(t))=V0+1Γ(η)0t(t-ξ)η-1Ψ(ξ,V(ξ))dξ. (21)

Let V,VY, then we have

SV-SV=|SV(t)-SV(t)|,=|1Γ(η)0t(t-ξ)η-1Ψ(ξ,V)-1Γ(η)0t(t-ξ)η-1Ψ(ξ,V)|dξ,1Γ(η)0t(t-ξ)η-1|Ψ(ξ,V)-Ψ(ξ,V)|dξ,V-V1Γ(η+1)KΨV-V.

Hence the model has unique solution by using Banach contraction theorem.

5. H-U stability

Here, we derive H-U type stability for (16), which lead us to the stability of system (2). Consider a small perturbation ϕC(J) with ϕ(0)=0.

Lemma 5.1

The perturbed problem

cDηV(t)=Ψ(t,V(t))+ϕ(t),V(0)=V0, (22)

solution obeys

V(t)-V0(t)+1Γ(η)0t(t-ξ)η-1Ψ(ξ,V(ξ))dξTηΓ(η+1)δ=CTδ. (23)

Proof

The proof is easy.

Theorem 5.2

Under hypothesis(A2) together with result(23)inLemma 5.1, the solution of the integral Eq.(17)is H-U stable and consequently, the numerical results of the considered system are H-U stable ifΛ=TηΓ(η+1)KΨ<1.

Proof

LetVΩ be a unique solution and VΩ be any solution of (17), then

|V(t)-V(t)|=|V(t)-V0(t)+1Γ(η)0t(t-ξ)η-1Ψ(ξ,V(ξ))dξ|,V(t)-V0(t)+1Γ(η)0t(t-ξ)η-1Ψ(ξ,V(ξ))dξ+V0(t)+1Γ(η)0t(t-ξ)η-1Ψ(ξ,V(ξ))dξ-V0(t)+1Γ(η)0t(t-ξ)η-1Ψ(ξ,V(ξ))dξ,CTδ+TηΓ(η+1)KΨV-V. (24)

From which we have

V-VCTδ+ΛV-U. (25)

From (25), we can write

V-VCT1-Λδ. (26)

Hence the required results about H-U stability.

6. Numerical algorithm and discussion

In this part of the paper, we have to evaluate approximate solutions of the model (2) under CFOD. Then the numerical simulations are acquired via the suggested scheme. To this aim, we employ the CFOD to establish a numerical procedure for the simulation of our considered model (2).

6.1. General algorithm

Here, we extend the numerical method of Euler for our considered model (2). The aforesaid considered model can be written as

cDtηSp(t)=Θ1(Sp,Ep,Ip,Ap,Rp,W)=Λp-mpSp-βpSp(Ip+kAp)-βWSPW,cDtηEp(t)=Θ1(Sp,Ep,Ip,Ap,Rp,W)=βpSp(Ip+kAp)+βWSpW-(1-δp)ωpEp-δpω´pEp-mpEp,cDtηIp(t)=Θ1(Sp,Ep,Ip,Ap,Rp,W)=(1-δp)ωpEp-(γp+mp)IpcDtηAp(t)=Θ1(Sp,Ep,Ip,Ap,Rp,W)=δpω´pEp-(γ´p+mp)ApcDtηRp(t)=Θ1(Sp,Ep,Ip,Ap,Rp,W)=γpIp+γp´Ap-mpRp,cDtηW(t)=Θ1(Sp,Ep,Ip,Ap,Rp,W)=μpIp+μ´pAp-εW. (27)

Let J be the interval of solution for (27). We subdivide the intervalJinto j subintervals [tq,tq+1]with uniform width h=T/m via using the nodes tq=qh, for q=0,1,m. Let

Sp(t),Ep(t),Ip(t),Ap(t),Rp(t),W(t),cDtηSp(t),cDtηEp(t),cDtηIp(t),cDtηAp(t),cDtηRp(t),cDtηW(t),

up to higher order are continuous on J. Applying the MEM about t=t0=0to the considered model expressed in (27) and for each value t take value a, the expression for t1, one has

Sp(t1)=Sp(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1)+cDt2ηSp(t)|t=at2ηΓ(2η+1),Ep(t1)=Ep(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1)+cDt2ηEp(t)|t=at2ηΓ(2η+1),Ip(t1)=Ip(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1)+cDt2ηIp(t)|t=at2ηΓ(2η+1),Ap(t1)=Ap(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1)+cDt2ηAp(t)|t=at2ηΓ(2η+1),Rp(t1)=Rp(t0)+Θ1(Sp(t0)),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1)+cDt2ηRp(t)|t=at2ηΓ(2η+1),W(t1)=W(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1)+cDt2ηW(t)|t=at2ηΓ(2η+1). (28)

Let the step size h is chosen small enough, then we may neglect the second-order term involving h2η and get the results from (28) as

Sp(t1)=Sp(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1),Ep(t1)=Ep(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0,W(t0))tηΓ(η+1),Ip(t1)=Ip(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1),Ap(t1)=Ap(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1),Rp(t1)=Rp(t0)+Θ1(Sp(t0)),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1),W(t1)=W(t0)+Θ1(Sp(t0),Ep(t0),Ip(t0),Ap(t0),Rp(t0),W(t0))tηΓ(η+1). (29)

Proceeding on aforesaid fashion, a general formula at tq+1=tq+h is established as

Sp(tq+1)=Sp(tq)+Θ1(Sp(tq),Ep(tq),Ip(tq),Ap(tq),Rp(tq),W(tq))hηΓ(η+1),Ep(tq+1)=Ep(tq)+Θ1(Sp(tq),Ep(tq),Ip(tq),Ap(tq),Rp(tq),W(tq))hηΓ(η+1),Ip(tq+1)=Ip(tq)+Θ1(Sp(tq),Ep(tq),Ip(tq),Ap(tq),Rp(tq),W(tq))hηΓ(η+1),Ap(tq+1)=Ap(tq)+Θ1(Sp(tq),Ep(tq),Ip(tq),Ap(tq),Rp(tq),W(tq))hηΓ(η+1),Rp(tq+1)=Rp(tq)+Θ1(Sp(tq)),Ep(tq),Ip(tq),Ap(tq),Rp(tq),W(tq))hηΓ(η+1),W(tq+1)=W(tq)+Θ1(Sp(tq),Ep(tq),Ip(tq),Ap(tq),Rp(tq),W(tq))hηΓ(η+1), (30)

where q=0,1,2,,m-1.

6.2. Numerical interpretation

Here in this subsection, graphical interpretation of numerical results to the concerned model is given. For this aim, we use the adopted scheme for the numerical simulation. Here, we choose some appropriate values for the parameters used in the model that is given in the Table 1 (see [28]). Graphical presentations are given in Figures 1-6, for various values of η. We construct an algorithm to simulate the results by using Matlab in Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6 .

Table 1.

Description of the parameters involve in the model (2).

Parameters Description of Parameters
Sp=800000 Susceptible people
Ep=200000 Exposed people
Ip=200 Infected people
Ap=250 Asymptomatic people
Rp=0 Recovered people
W=50000 Resivior
mp=0.1 Rate of death
Λp=np×Np=5000 Total population and birth rate
ωp=0.01 Incubation period
ωp´=0.768 Latent period
γp=1.05 Infectious period of symptomatic infection
γp´=0.00001 Infectious period of asymptomatic infection of people
βp=0.00006 Transmission rate from Ip to Sp
βw=.000010 Transmission rate fromWto Sp
μp=0.1 Shedding coefficients from Ip to W
μp´=0.0003 Shedding coefficients from Ap to W
δp=0.009 Proportion of asymptomatic infection rate of people
k=0.00654 Multiple of the transmissibility of Ap to that of Ip
=0.09 Lifetime of the virus in W

Fig. 1.

Fig. 1

Graph of approximate solution for susceptible class at different fractional values of η.

Fig. 2.

Fig. 2

Graph of approximate solution for exposed class at different fractional values of η.

Fig. 3.

Fig. 3

Graph of approximate solution for symptomatic infected class at different fractional values of  η.

Fig. 4.

Fig. 4

Graph of approximate solution for asymptomatic infected class at different fractional values of  η.

Fig. 5.

Fig. 5

Graph of approximate solution for recovered people at different fractional values of  η.

Fig. 6.

Fig. 6

Graph of approximate solution for reservoir class at different fractional values of  η.

In Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6 we have presented the plot for the different compartments of the considered model corresponding to various fractional values order η. We have presented the numerical results for initial 200 days. Initially the infection in first month that first thirty days was increasingly transmitted but on time control the China government implemented strict precautionary measures which controlled the disease very well in coming two months. In Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, we have given the evolution of COVID-19 in Wuhan city for initial 200 days. Further, From the Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, one can observe that the considered model extremely depends on the order and offers more degree of flexibility. As we increase the values of the η, we see that the solution tends to integers order solution. The growing and decaying rate of various classes of model is different at different fractional order. Therefore fractional calculus can be helpful in understanding the transmission dynamics of COVID-19. Here we, remark that at smaller fractional order the decay process is faster while the growth rate is slow. Increasing the fractional order the process of decay may become slow while,the grow rate goes on raising. Further, the fractional order has great impact on the transmission dynamics of the proposed model. Also, it helps in better understanding of physical behaviour of spreading of infection in a community. Moreover, the adopted numerical method can be used as a fruitful technique to achieve computational results for such type nonlinear problems. The concerned growth or decay process of various compartments is faster slightly at lower fractional order as compared to greater value of η.

7. Conclusion

We have established some qualitative results for the mathematical model (2) involving CFOD. Using the nonlinear analysis, we have derived feasibility of the solution and bounded ness of the result to the concerned model. Also, we derived the reproductive number for the model under study. For the needed results about existence and uniqueness of solution fixed point theory has been used. Also we have developed the Ullam-Hyers stability results for the considered model. Further, we have computed numerical solutions for the considered model via a powerful technique due to Euler. Graphical representations have been given to check the dynamical behavior of solution by using Matlab. We have computed the results regarding to distinct values of fractional orders. The gained results play crucial part in showing the theory of fractional analytical dynamic for the existing outbreak due to COVID −19 which has badly affected the entire globe. From the computations we observed that the increase or decrease in different compartments is faster at higher fractional order of the derivative and we see that fractional calculus has the ability to explain the papulation dynamics more comprehensively. The presented results may be fruitful for the existing outbreak in a better way and can be used in taking defensive techniques to decrease the infection. In future the proposed scheme can be utilized to investigate more nonlinear problems of FODEs involving CFOD.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Acknowledgement

We are thankful to the reviewers for their useful suggestions.

Footnotes

Peer review under responsibility of Faculty of Engineering, Alexandria University.

References

  • 1.W.H. Organization, Corona-virus World Health Organization, Available: https://www.who.int/health-topics/coronavirus (cited January 19, 2020).
  • 2.Bogoch I.I., et al. Pneumonia of unknown aetiology in Wuhan, China: potential for international spread via commercial air travel. J. Travel Med. 2020;27(2):taaa008. doi: 10.1093/jtm/taaa008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Chen T., Ka-Kit Leung R., Liu R., Chen F., Zhang X., Zhao J., Chen S. Risk of imported Ebola virus disease in China. Travel Med. Infect. Disease. 2014;12(1):650–658. doi: 10.1016/j.tmaid.2014.10.015. [DOI] [PubMed] [Google Scholar]
  • 4.Yi B., Chen Y., Ma X., Rui J., Cui J.A., Wang H., Li J., Chan S.F., Wang R., Ding K., Xie L., Zhang D., Jiao S., Lao X., Chiang Y.C., Su Y., Zhao B., Xu G., Chen T. Incidence dynamics and investigation of key interventions in a dengue outbreak in Ningbo City, China. PLOS Neglected Trop. Diseases. 2019;13(8):e0007659. doi: 10.1371/journal.pntd.0007659. eCollection 2019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Chen T., Jia R., Qiupeng W., Zeyu Z., Jui A.C., Ling X. A mathematical model for simulating the phase-based transmissibility of a novel coronavirus. Infect. Diseases Poverty. 2020;9(24):1–8. doi: 10.1186/s40249-020-00640-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Podlubny I. Academic Press; New York: 1999. Fractional Differential Equations, Mathematics in Science and Engineering. [Google Scholar]
  • 7.Kilbas A.A., Srivastava H., Trujillo J. vol. 204. Elseveir; Amsterdam: 2006. (Theory and application of fractional differential equations North Holland Mathematics Studies). [Google Scholar]
  • 8.Nazir G., Shah K., Debbouche A., Khan R.A. Study of HIV mathematical model under nonsingular kernel type derivative of fractional order. Choas Solit. Fract. 2020;139:110095. [Google Scholar]
  • 9.Wang Z., Yang D., Ma T., Sun N. Stability analysis for nonlinear fractional-order systems based on comparison principle. Nonlinear Dyn. 2014;75(1–2):387–402. [Google Scholar]
  • 10.Lakshmikantham V., Leela S., Vasundhara j. Cambridge Academic Publishers; Cambridge, UK: 2009. Theory of Fractional Dynamic Systems. [Google Scholar]
  • 11.Ali A., Shah K., Khan R.A. Numerical treatment for traveling wave solutions of fractional Whitham-Broer-Kaup equations. Alexedria Eng. J. 2018;57(3):1991–1998. [Google Scholar]
  • 12.A. Alawneh, Application of the multistep generalized differential transform method to solve a time-fractional enzyme kinetics, Discrete Dyn. Nature Soc. (2013) 7.
  • 13.Liao S.J. A kind of approximate solution technique which does not depend upon small parameters: a special example. Int. J. Nonlinear Mech. 1995;30:371–380. [Google Scholar]
  • 14.Nazir G., Shah K., Alrabaiah H., Khalil H., Khan R.A. Fractional dynamical analysis of measles spread model under vaccination corresponding to nonsingular fractional order derivative. Adv. Differ. Equ. 2020;2020:171. [Google Scholar]
  • 15.Ali G., Nazir G., Shah K., Li Y. Existence theory and novel iterative method for dynamical system of infectious diseases. Discr. Dyn. Nature Soc. 2020;2020:171. [Google Scholar]
  • 16.Zaid M.O., Shawagfeh N. Generalized Taylor’s formula. Appl. Math. Comput. 2007;186:286–293. [Google Scholar]
  • 17.Abdeljawad T., Hajji M.A., Al-Madllal Q.M., Jarad F. Analysis of some generalized ABC-fractional logistic models. Alexandria Eng. J. 2020;59:2141–2148. [Google Scholar]
  • 18.B. Ghanbari, S. Kumar, R. Kumar, A Study of behaviour for immune and tumor cells in immunogentic tumor model with non-singular fractional derivative, Choas Solit. Fract 133 (2020) 109619.
  • 19.Kumar S., Kumar R., Cttani C., Samet B. Chaotic behaviour of fractional predator-prey dynamical system. Choas Solit. Fract. 2020;135:109811. [Google Scholar]
  • 20.S. Kumar, A. Kumar, B. Samet, J.F. Gomez -Aguilar, M.S.Osman, A choas study of tumor and effector cells in fractional tumor immune model for cancer treatment, Choas Solit. Fract. 141 (2020) 110321.
  • 21.Yavuz M., Ozdemir N. Analysis of an epidemic spreading model with exponential decay law. Math. Sci. Appl. E-Notes. 2020;8(1):142–154. [Google Scholar]
  • 22.P.A. Naik, M. Yavuz, S. Qureshi, J. Zu, S.Townley, Modelling and analysis of CoVID-19 epidemics with treatment in fractional derivatives using real data from Pakistan, Eur. Phys. J. Plus 135 (2020) 795 doi: 10.1140/epjp/s13360-020-00819-5. [DOI] [PMC free article] [PubMed]
  • 23.Abdeljawad T., Al-Madallal Q.M., Jarad F. Fractional Logistic models in the frame of fractional operators generated by conformable derivatives. Choas Solit. Fract. 2019;119:94–101. [Google Scholar]
  • 24.Yavuz M., Sene N. Stability analysis and numerical computational of the fractional predator- prey model with the harvesting rate. Fractal Fract. 2020;4(35) doi: 10.3390/fractalfract4030035. [DOI] [Google Scholar]
  • 25.Jarad F., Abdeljawad T., Hammouch Z. On class of ordinary differential equations in the frame of Atangana-Baleanu fractional derivative. Choas Solit. Fract. 2020;117:16–20. [Google Scholar]
  • 26.Ahmed I., Modu G.U., Yusuf A., Kumar P., Yusuf I. A mathematical model of Coronavirus disease (COVID-19) containing asymptomatic and symptomatic classes. Res. Phys. 2021;21:103776. doi: 10.1016/j.rinp.2020.103776. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Naik P.A., Owolabi K.M., Yavuz M., Zu J. Choatic dynamics of fractional order HIV-1 model involving AIDS- related cancer cells. Choas Solit. Fract. 2020;140:110272. [Google Scholar]
  • 28.Khan M.A., Atangana A. Modelling the dynamics of noval coronavirus (2019-ncov) with fractional derivative. Alexandria Eng. J. 2020 doi: 10.1016/j.aej.2020.02.033. [DOI] [Google Scholar]
  • 29.Keten A., Yavuz M., Baleanu D. Nonlocal cauchy problem via a fractional operator involving power kernal in Banach spaces. Fractals Fract. 2019;3(27) [Google Scholar]
  • 30.Vareesha P., Parkasha D.G., Kumar S. Afractional model for propogation of classical optical solitons by using nonsingular derivative. Math. Meth. Appl. Sci. 2020:1–15. [Google Scholar]
  • 31.Yavuz M. Novel solution methods for initial boundary value problems of fractional order with conformable differentiation An International. J. Optim. Control: Theories Appl. 2018;8(1):1–7. doi: 10.11121/ijocta.01.2018.00540. [DOI] [Google Scholar]
  • 32.Adiga A., Dubahashi D., Lewis B., Marathe M., Venkatramanan S., Vulikanti A. Mathematical model for COVID-19 pandemic: A comparative analysis. J. Indian Inst. Sci. 2020;100(4):793–807. doi: 10.1007/s41745-020-00200-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 33.O. Zakary, S. Bidah, M. Rachile, H. Ferjouclia, Mathematical Model to estimate and optimal control strategy, J. Appl. Math. 2020 Article ID 9813926, p. 13. doi: 10.1155/2020/9813926.
  • 34.Kyrychko Y.N., Blyuss K.B., Brovchenko I. Mathematical modelling of the dynamics and containment of COVID-19 in Ukraine. Sci. Rep. 2020;10(1):19–66. doi: 10.1038/s41598-020-76710-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Khoshnaw S.H.A., Salih R.H., Sulaimany S. Mathematical modelling for coronavirus disease (COVID-19) in predicting future behaviour and sensitivity analysis. Math. Modell. Natural Phenomena. 2020;15:33. doi: 10.1051/mmnp/2020020. [DOI] [Google Scholar]
  • 36.Shaikh A.S., Shaikh I.N., Nisar K.S. A mathematical model of COVID-19 using fractional derivative: outbreak in India with dynamics of transmission and control. Adv. Differ. Equ. 2020;2020:373. doi: 10.1186/s13662-020-02834-3. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Alexandria Engineering Journal are provided here courtesy of Elsevier

RESOURCES