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. 2020 Dec;73(6):1594–1595. doi: 10.1016/j.jhep.2020.08.030

Corrigendum to: “Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis” [J Hepatol (2020) 241-251]

Constantinos A Parisinos 1,∗,†, Henry R Wilman 2,3,†, E Louise Thomas 2, Matt Kelly 3, Rowan C Nicholls 3, John McGonigle 3, Stefan Neubauer 3,4, Aroon D Hingorani 5, Riyaz S Patel 5, Harry Hemingway 6, Jimmy D Bell 2, Rajarshi Banerjee 3,‡, Hanieh Yaghootkar 2,7,8,∗,‡
PMCID: PMC8055539  PMID: 32951912

It has come to our attention that there are errors in the Table 2 of the original manuscript “Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis”.

Table 2.

The association between 6 independent genetic variants and liver cT1. A linear mixed model was used for genetic associations (levels of significance: p <5 × 10-8).

SNP CHR Base pairs EA OA EAF Gene Variant type Amino acid change BETA Standard error p value Variance explained (%)
rs759359281 1 220,100,497 C CA 0.06 SLC30A10 Intron 0.137 0.026 2.8 × 10-8 0.23
rs13107325 4 103,188,709 T C 0.07 SLC39A8 Missense A391T 0.544 0.022 1.2 × 10-133 3.95
rs111723834 14 24,572,932 A G 0.02 PCK2 Missense, Intron R561Q 0.291 0.046 3.0 × 10-11 0.27
rs58542926 19 19,379,549 T C 0.07 TM6SF2 Missense E167K 0.124 0.022 1.4 × 10-8 0.22
rs4820268∗ 22 37,469,591 G A 0.46 TMPRSS6 Synonymous D521D 0.066 0.012 1.6 × 10-9 0.2
rs738409 22 44,324,727 G C 0.21 PNPLA3 Missense I148M 0.095 0.014 9.6 × 10-13 0.29

The coordinates and SNP IDs are in build 37. Effects are in SD. Beta represents effects in standard deviation (SD). CHR, chromosome; EA, effect allele; EAF, effect allele frequency; OA, other allele.

∗

rs4820268 is in LD (r2 = 0.77) with rs855791 (V736A).

The Variance Explained for SNP rs738409 has been incorrectly reported as 0.9. The correct value is 0.29. The amino acid changes for SNPs rs111723834, rs58542926 and rs738409 have been incorrectly reported as A561G, I148M and E167K, respectively. The correct amino acid changes are R561Q, E167K and I148M, respectively. SNP rs4820268 variant type (synonymous) and amino acid change (D521D) have also been corrected. Please see the corrected Table 2 below. These errors have occured during manual editing of the table and do not affect the results and conclusions of this article.

The authors would like to apologise for any inconvenience caused.

Contributor Information

Constantinos A. Parisinos, Email: c.parisinos@ucl.ac.uk.

Hanieh Yaghootkar, Email: h.yaghootkar@exeter.ac.uk.

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