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. 2021 Mar 23;11(12):5620–5633. doi: 10.7150/thno.55333

Figure 6.

Figure 6

Representative picrosirius red-stained melanoma tissue micrographs imaged under bright-field and polarized light. A. The presence of collagen fibers near MNPs in control untreated mice melanoma tumor tissue. B. The absence of collagen fibers in MH-treated mice melanoma tumor tissue samples with low local cellularity. In contrast, collagen fibers are present in tumor tissue samples with high local cellularity. With ΔTMax < 8.5 °C, collagen fibers are found both close to MNPs and distant from MNPs (> 1 mm from MNPs); with ΔTMax > 8.5 °C, collagen fibers are found only at area farther away from MNPs. Blue asterisks in the bright-field microscopy images indicate MNPs. Note that 8.5 °C was selected as the reference value as it represents the mean ΔTMax achieved in the highly cellular tumors after the 2nd MH treatment (Table S1).