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. 2021 Apr 3;11(12):5986–6005. doi: 10.7150/thno.58632

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Composition of antioxidant miRNAs in MSC-EVs. (A) miRNA sequencing from MSC-EVs and conditioned EVs. (B) Volcano map of downregulated (blue) and up-regulated (red) miRNAs in conditioned EVs. (C) GO Classification of exosomal miRNA target genes (n = 58) associated with the antioxidant activity molecular function. (D) ELISA test for 8-OHdG generation in H2O2-stimulated hippocampal neurons after adding miRNA inhibitors and mimics (n = 5 per group). MSC-EVs: mesenchymal stem cell-derived extracellular vesicles; ns: no significance; n: number; GO: gene ontology; 8-OHdG: 8-hydroxy-2 deoxyguanosin. * p < 0.05 (vs. Control group), # p < 0.05 (vs. H₂O₂+PBS), ## p < 0.01 (vs. H₂O₂+PBS), ### p < 0.001 (vs. H₂O₂+PBS), ns p > 0.05 (vs. H₂O₂+PBS).