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Ligands and receptors of the tumor necrosis factor (TNF)/lymphotoxin system. Both heterotrimeric LTα1/β2 and homotrimeric LIGHT bind to LTβR. Herpes virus entry mediator (HVEM) binds to membrane LIGHT and soluble homotrimeric LTα3. Membrane TNFα (mTNFα), soluble TNFα (sTNFα), and LTα3 bind to TNFRI and TNFR II.
