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. 2021 Mar 30;9(4):351. doi: 10.3390/biomedicines9040351

Figure 2.

Figure 2

During primary infection, HCMV employs various mechanisms to mediate immune evasion. HCMV expresses viral genes and proteins that interfere with host interferon responses (pp65), inhibit natural killer cell recognition or activation (pUL40 and pUL18), inhibit CD4+ and CD8+ T-cell recognition by preventing MHC Class I and II antigen processing and presentation (e.g., US2, US3, US6, US10, US11). CMV IL-10 (viral IL-10 homologue) produced by infected cells further acts to suppress CD4+ and C8+ T cell responses. HCMV, human cytomegalovirus; MHC, major histocompatibility complex (MHC); US, unique short; UL, unique long. Figure created with BioRender.com.