Table 2.

Studies on dietary compounds effects on the activity of CETP of HDL-C.

Author, Year	Bioactive Compounds	Dose/Time	Study Design n	Main Results on CETP Activity
Hernáez, 2017 [27]	TMD- EVOO TMD- Nuts	1 L/week 1 year	Randomized controlled trial subsample PREDIMED study 296 subjects (TMD-VOO; n = 100 and TMD-Nuts; n = 100, low-fat control diet; n = 96).	↓ CETP activity after TMD-EVOO intervention to baseline (−0.039; p = 0.008).
Hernáez, 2019 [81]	Legumes Fresh fish	25 g/d (2 servings/week) each one 1 year	Randomized controlled trial subsample PREDIMED study 296 older adults of high cardiovascular risk (50–80 years)	25 g legumes ↓ 4.8% (p = 0.0028) CETP activity 25 g fish consumption ↓ 2.3% CEPT activity
Elseweidy, 2015 [80]	Curcuminoids and ginger	50 mg/kg/d 200 mg/kg/d 6 weeks	In vivo Study Experimental animal model (rabbit model) Fed high-cholesterol diet 6 weeks 3 groups: 1.TGE (n = 6) 2. Curcuminoids (n = 6) 3. Placebo (n = 6)	↓ hepatic CETP mRNA expression TGE, curcuminoids vs. placebo (8.7 ± 0.7; 8.4 ± 0.5 vs. 11 ± 0.5; p < 0.001); respectively. ↓ plasma CETP (199 pg/mL ± 4; 152 ± 5 vs. 315 ± 12; p < 0.001); respectively. Ginger was more effective in ↓ plasma CETP (152 pg/mL ± 5 vs. 199 ± 4; p < 0.001) than curcuminoids.

Abbreviations and symbols: HPCOO, high polyphenol content olive oil; LPCOO, low polyphenol content olive oil; CETP, cholesterol ester transporter protein; SD, standard deviation; TMD-EVOO, traditional Mediterranean diet enriched with extra virgin olive oil; TMD-Nuts, traditional Mediterranean diet enriched with nuts; PREDIMED, PREvención con DIeta MEDiterránea; TGE, total ginger extract; mRNA, messenger RNA. ↓: decreasing.