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. Author manuscript; available in PMC: 2021 Apr 24.
Published in final edited form as: Cell. 2021 Mar 4;184(5):1142–1155. doi: 10.1016/j.cell.2021.02.020

Figure 1. Categories of cancer targets.

Figure 1.

Recent studies have identified an expanded universe of cancer targets that include both tumor intrinsic targets and extrinsic targets including components of the tumor microenvironment. Among growing number of emerging targets (in green), the concept of oncogenic cell states captures the multi-dimensional complexity of a tumor with dynamic transition states, underlying regulatory mechanisms, and subpopulation-dependent plasticity that defines cellular phenotype and therapeutic response. These new targets are the consequence of tumor heterogeneity and represent non-oncogene-dependent cancer vulnerabilities, which inform new types of therapeutic opportunities.