Table 1.
Modulation of the signaling transduction pathway by flavonoids in TNBC through targeting micro RNAs. This is the summary table in which the detailed description and references are described in the text.
| Flavonoids | Targeted Pathways | Micro RNA Involved in the Pathway | Main Effects of Flavonoids on the Pathway |
|---|---|---|---|
| Quercetin | PKC | miR-200b | Inhibit |
| Chrysin | Nrf2/keap1 | miR-29b-1-5p | Inhibit |
| Luteolin | Inhibit | ||
| Apigenin | Inhibit | ||
| Epgallocatechin-3-gallate | Inhibit/Activate | ||
| Thymoquinone | Activate | ||
| Quercetin | PI3K/Akt | miR-184 | Inhibit |
| Myricetin | MAPK/ERK | miR-489 | Inhibit |
| Fisetin | NF-Kβ | miR-21 | Inhibit |
| Luteolin | JAK/STAT3 | miR-18a, mir-30, miR-155, miR-221 | Inhibit |
| Quercetin | |||
| Quercetin | Wnt/β-catenin | miR-1260b | Inhibit |
| Apigenin | |||
| Fisetin | |||
| Curcumin | SMAD | miR-27a, miR-3613-3P | Inhibit |
Abbreviations: PKC—Protein kinase C, Nrf2—Nuclear factor erythroid 2–related factor 2, Keap1—Kelch–like ECH–associated protein 1, PI3K/Akt—phosphatidylinositol 3-kinase/Protein kinase B, JAK/STAT3—Janus-activated kinase pathway/Signal transducer and activator of transcription 3, NF-Kβ—nuclear factor kappa-light-chain-enhancer of activated B cells, Wnt—Wingless and Int–1, MAPK/ERK—mitogen-activated protein kinase/extracellular signal-regulated kinases, SMAD—Smooth-muscle-actin and MAD-related proteins.