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. 2021 Apr 7;11(4):226. doi: 10.3390/metabo11040226

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Fidarestat (aldose reductase inhibitor) decreased the ¹³C enrichments of HUVEC glycolytic and TCA metabolites, as well as amino acids, nucleotide precursors, and UDP-glucose. (a) Heatmap comparing ¹³C metabolite enrichment of untreated HUVECs and fidarestat-treated HUVECs. ¹³C enrichment of (b) glycolytic metabolites, (c) TCA metabolites, (d) amino acids, (e) AMP and UMP, and (f) UDP-glucose. Statistical significance for (b–f) determined through Welch’s unequal variances t-test; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. n = 6 biological replicates.