Skip to main content
. 2021 Apr 9;26(8):2157. doi: 10.3390/molecules26082157

Figure 2.

Figure 2

(a) Crystal structure of SARS-CoV-2 spike receptor-binding domain (green) bound with human ACE2 receptor (blue), the fragment of α1-helix selected as a prototype for peptide design is shown in red (PDB ID: 6M0J). The ACE2 catalytic motif (H345, P346, H374, E375, H378, and E402) is shown as magenta sticks. (b) Close up view of interacting interface between RBD and α-helical fragment D30-Q42 of ACE2. The crucial residues are presented as sticks (yellow/protein, red/peptide); Q493 is shown in two alternative positions. Prototype peptide sequence is also shown; residues responsible for interactions with protein are underlined.