Figure 3.

Aging increases abundance of fibrosis and inflammation markers in renal cortex of Trpc6 ^wt/wt and Trpc6 ^del/del rats. Representative immunoblots are shown to the left. Bar graphs to the right denote mean ± SD of densitometric analyses from multiple animals in each group. Data are shown for vimentin (a), α-smooth muscle actin (b), NLRP3 (c) and IL−1β precursor protein (d). TRPC6 deletion did not prevent aging-induced increases in markers of renal fibrosis and inflammation. Specific groups were compared by Student’s t-test (n = 4 animals per group).