Figure 1.

Speculative association of paraoxonase 1 (PON1) with nonalcoholic fatty liver disease (NAFLD). There are different grades of NAFLD, including steatohepatitis. Various molecules are associated with the development of the disease, and oxidative stress is a key to its progression. Antioxidants have a defensive role against the excess oxidative stress. Paraoxonase 1 (PON1), an antioxidant molecule, is produced in the liver and is secreted into the circulation; therefore, PON1 may play a relevant role in the pathophysiology of NAFLD. Circulating PON1 levels could serve as surrogate biomarkers of the underlying cause of the disease.