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siRNA knockdown of apical kinases of the DNA damage response pathway modulates proliferation and gene expression. (a) SMC were transfected with siRNA targeted to ATM, (b) ATR or (c) DNA-PK for 6 h and then placed into FGM for up to 7 days. Cell counts were performed on days 0, 2, 4 and 7 (n = 4). RNA was extracted at 72 h and the expression of (d) miRNA-145, (e) ATM, (f) ATR, (g) DNA-PK and (h) p21 measured using RT-PCR (n = 5).
