Figure 1.

Mammalian SET1 family of methyltransferases. The figure depicts the structure of each family member with variable number of DNA binding motifs and protein-protein interaction domains. All the six methyltransferases contain a SET and post-SET domain at the C-terminal. The number of amino acids (aa) shown, represents the length of each protein. AT hook: AT-rich region, CXXC: Cysteine-rich region, PHD: Plant homeodomain, Bromo: Bromodomain, HMG: High mobility group box, FYRN/C: Phenylalanine and tyrosine-rich region N-terminal/C-terminal, RRM: RNA recognition motif, SET: Suppressor of variegation 3–9, enhancer of zeste and trithorax, N-SET: N-terminal of SET, Post-SET: C-terminal of SET