Table 1. Plateau potential parameters in ClCadrand 9-AC treated unaffected muscle.
| Pre-myotonia vm (mV) | Initial PP vm (mV) | PP repol slope (mV/s) | Final PP vm (mV) | Max repol rate (mV/s) | Post PP vm (mV) | Duration of PP (s) | |
|---|---|---|---|---|---|---|---|
| ClCadr | −80.4 ± 2.9 (-80.0) | −35.2 ± 4.2 (−35.8) |
−0.25 ± 0.19 (−0.17) |
−46.3 ± 2.9 (−46.7) |
250 ± 78 (246) |
−80.4 ± 2.9 (−79.7) |
81.9 ± 47.6 (74.4) |
| 9-AC | −81.5 ± 2.6 (-82.4) | −31.2 ± 3.1* (−31.4) |
−3.4 ± 1.8** (−3.5) | −45.2 ± 2.3 (−45.1) |
197 ± 44+
(192) |
−80.8 ± 2.9 (−81.6) |
11.7 ± 25.0++
(4.1) |
Shown are the mean value ± the standard deviation for parameters of plateau potentials in ClCadr fibers and 9-AC treated fibers. Below the mean value is the median value in parenthesis. n = 26 fibers with plateau potentials from 10 ClCadr mice and 49 fibers with plateau potentials from eight unaffected muscles treated with 9-AC. Vm is membrane potential, and repol is repolarization. Pre-myotonia Vm is the resting membrane potential prior to stimulation. Initial PP Vm is the membrane potential at the beginning of the plateau potential. Final PP Vm is the membrane potential prior to the sudden repolarization terminating the plateau potential. Max repol rate is the maximum rate of repolarization during the sudden repolarization. Post PP Vm is the membrane potential following termination of the plateau potential. * indicates p<0.05, ** indicates p<1 × 10−20 of log transformed data. + indicates p<0.01. ++ indicates p<1 × 10−18 of log transformed data.