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. 2021 Apr 28;15(4):629–637. doi: 10.1007/s11684-020-0825-2

Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD) and non-CCVD patients

Yu Wang 1,#, Lan Li 1,#, Yuanjiang Pan 2, Yu He 3, Zuhua Chen 5, Yunhao Xun 5, Yuhan Xu 1, Yilei Guo 1, Jiehong Yang 4,✉, Jianchun Guo 5,✉, Haitong Wan 1,✉
PMCID: PMC8079836  PMID: 33909258

Abstract

Cardio-cerebrovascular disease (CCVD) is a major comorbidity of Coronavirus disease 2019 (COVID-19). However, the clinical characteristics and outcomes remain unclear. In this study, 102 cases of COVID-19 from January 22, 2020 to March 26, 2020 in Xixi Hospital of Hangzhou were included. Twenty cases had pre-existing CCVD. Results showed that compared with non-CCVD patients, those with CCVD are more likely to develop severe disease (15% versus 1%), and the proportion of pneumonia severity index grade IV was significantly higher (25% versus 3.6%). Computed tomography images demonstrated that the proportion of multiple lobe lesion involvement was significantly higher in the CCVD group than in the non-CCVD group (90% versus 63.4%). Compared with non-CCVD group, the levels of C-reactive protein, fibrinogen, D-dimer, and serum amyloid-A were higher, whereas the total protein and arterial partial PaO2 were lower in the CCVD group. Although no statistical difference was observed in the outcomes between groups, CCVD patients received more intensive comprehensive treatment to improve COVID-19 symptoms compared with non-CCVD patients. Integrated Chinese and Western medicine treatments have certain advantages in controlling the severe conversion rate and mortality of COVID-19. In addition, given that COVID-19 patients are usually related to coagulation disorders and thrombosis risk, the application of Chinese medicine in promoting blood circulation and removing stasis should be strengthened.

Keywords: COVID-19, cardio-cerebrovascular disease, traditional Chinese medicine, clinical features, clinical therapeutics

Acknowldgements

This work was supported by the National Natural Science Foundation of China (No. 81930111) and Zhejiang Province High-level Talents Project (No. 2019R51002).

Footnotes

Compliance with ethics guidelines

Yu Wang, Lan Li, Yuanjiang Pan, Yu He, Zuhua Chen, Yunhao Xun, Yuhan Xu, Yilei Guo, Jiehong Yang, Jianchun Guo, and Haitong Wan declare no conflict of interest. Given the retrospective nature of this study, informed consent was waived. The study was approved by the Ethics Committee of Xixi Hospital of Hangzhou (Approval No.: 2020-14).

Yu Wang and Lan Li contributed equally to this work.

Contributor Information

Jiehong Yang, Email: yjhong@zcmu.edu.cn.

Jianchun Guo, Email: guojianchun1961@126.com.

Haitong Wan, Email: haitongw@163.com.

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