Efficient maternofetal transplacental transfer of anti- SARS-CoV-2 spike antibodies after antenatal SARS-CoV-2 BNT162b2 mRNA vaccination

Amihai Rottenstreich; Gila Zarbiv; Esther Oiknine-Djian; Roy Zigron; Dana G Wolf; Shay Porat

doi:10.1093/cid/ciab266

. 2021 Apr 3:ciab266. doi: 10.1093/cid/ciab266

Efficient maternofetal transplacental transfer of anti- SARS-CoV-2 spike antibodies after antenatal SARS-CoV-2 BNT162b2 mRNA vaccination

Amihai Rottenstreich ^1,^✉, Gila Zarbiv ¹, Esther Oiknine-Djian ², Roy Zigron ¹, Dana G Wolf ², Shay Porat ¹

PMCID: PMC8083549 PMID: 33822014

Abstract

Maternal and cord blood sera were collected from 20 parturients who received the BNT162b2 vaccine. All women and infants were positive for anti S- and anti-RBD-specific IgG. Cord blood antibody concentrations were correlated to maternal levels and to time since vaccination. Antenatal SARS-CoV-2 vaccination may provide maternal and neonatal protection.

Keywords: pregnancy, vaccination, cord blood, serology, SARS-CoV-2

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Efficient maternofetal transplacental transfer of anti- SARS-CoV-2 spike antibodies after antenatal SARS-CoV-2 BNT162b2 mRNA vaccination

Amihai Rottenstreich, MD

Gila Zarbiv, RN, CNM

Esther Oiknine-Djian, PhD

Roy Zigron, MD

Dana G Wolf, MD

Shay Porat, MD

Abstract

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Efficient maternofetal transplacental transfer of anti- SARS-CoV-2 spike antibodies after antenatal SARS-CoV-2 BNT162b2 mRNA vaccination

Amihai Rottenstreich, MD

Gila Zarbiv, RN, CNM

Esther Oiknine-Djian, PhD

Roy Zigron, MD

Dana G Wolf, MD

Shay Porat, MD

Abstract

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