Endocrinol Metab 2017;32:296–301.
https://doi.org/10.3803/EnM.2017.32.2.296
In the published article, there was an incorrect amino acid change in Table 1. The “p.Ser383Pro” should be changed to “p.Ser383Leu.” The corrected table is shown below.
Table 1.
Bioinformatics Analysis of GCK Mutations
| Case | GCK exon | PolyPhen-2/SIFT prediction | Amino acid change | DUET predicted stability changes (ΔΔG) | Reference |
|---|---|---|---|---|---|
| Family 1 | 2 | 1/Damaging | c.92T>C, p.Leu30Pro | −2.175 Kcal/mol (Destabilizing) | [6] |
| Family 2 | 9 | 1/Damaging | c.1151C>T, p.Ser383Leu | −0.465 Kcal/mol (Destabilizing) | [6] |
Two mutations were predicted to be deleterious using online prediction tools. DUET is a web server that uses an integrated computational approach to study missense mutations in proteins; it is available at http://structure.bioc.cam.ac.uk/duet.
GCK, glucokinase; PolyPhen-2, polymorphism phenotyping v2.
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