CARDIOVASCULAR AND MORTALITY OUTCOMES IN ONCOLOGY PATIENTS HOSPITALIZED WITH COVID-19

Background

Cancer patients have been shown to have increased mortality with COVID-19 infection, particularly those with metastases. We sought to examine the cardiovascular comorbidities associated with cancer patients hospitalized with COVID-19 and their association with cardiovascular outcomes and mortality.

Methods

We performed a retrospective study of 3,272 hospitalized COVID-19 patients using the Yale New Haven Hospital COVID-19 database. Chi-square, and multivariate regression analyses were performed to assess the influence of cancer and presence of metastases on cardiovascular outcomes and mortality in COVID-19 patients.

Results

Patients with cancer were older, had more cardiovascular comorbidities, and greater in-hospital heart failure, atrial arrhythmia, and death (table). Metastases was present in 31.6% of cancer patients. On multivariate analysis, the presence of metastases increased the risk for in-hospital death (odds ratio, 1.92; 95% confidence interval, 1.13-3.25; P=0.016), but neither cancer nor cancer with metastases was independently associated with in-hospital heart failure or arrhythmia.

Conclusion

Metastatic disease was independently associated with a higher risk of mortality in COVID-19 patients. Although cancer patients had higher cardiovascular co-morbidities, neither cancer nor metastatic disease was independently associated with increased risk of heart failure or atrial arrhythmia in the setting of COVID-19 infection.