FIG 6.

Multi-omics analysis of BMDM-EVs under different cryptococcal stimulations. (A) Protein and cholesterol levels of three types of EV samples. Lower protein and lipid levels are shown in Hk-BM-EVs (EVs from heat-killed C. neoformans-infected activated BMDMs). *, P < 0.05 by ANOVA. (B) Ratios of protein to cholesterol in three types of EV samples. (C) Differentially expressed proteins in EVs (n = 3 for each type of EV). (D) Pathway analysis of differentially expressed proteins in EVs. (E) Differentially expressed lipids in EVs (n = 3 for each type of EV). Live-BM-EVs, EVs from live C. neoformans-infected activated BMDMs; Non-BM-EVs, EVs from activated BMDMs without C. neoformans infection.