Figure 2.

CK2α overexpression overcomes temporal restriction of MYC-induced lymphocyte transformation and induces leukemia at the later stage of development. (A) Diagram of the experimental design. (B) Thymic fluorescence in MYC-ER and MYC-ER;CK2αwt zebrafish that were raised in 129 nM 4-hydroxytamoxifen (4HT) beginning at 30 dpf. (C) Kaplan-Meier analysis of tumor-free fish based on genotype (P<0.0001; n=18 for MYC-ER and n=34 for MYC-ER;CK2αwt fish). Statistical analysis was performed using the log-rank test and scale bars =1 mm.