NCT03082625.

Study name	Topical magnesium and muscle cramps in dialysis patients
Methods	Randomized, placebo‐controlled, cross‐over trial
Participants	People on haemodialysis
Interventions	Transdermal spray of magnesium versus transdermal spray containing vehicle only (5 sprays each on the 2 most affected muscle groups twice daily). 8‐week treatment periods and 4‐week washout in between
Outcomes	Primary: difference between groups in the number of cramps per week on treatment during the final 3 weeks on treatment. Secondary: difference in cramp duration and difference in cramp severity (final 3 weeks); percentage change in serum magnesium from baseline at the end of treatment; difference in restless leg symptoms
Starting date	1 May 2017
Contact information	Neil Boudville (Head of Dept of Renal Medicine, Sir Charles Gairdener Hospital)) e‐mail: neil.boudville@uwa.edu.au
Notes	ClinicalTrials.gov registration: NCT03082625