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. 2021 May 4;10(5):515. doi: 10.1002/open.202100095

Front Cover: Synthesis of Tetra‐Substituted Trifluoromethyl‐3,1‐Benzoxazines by Transition‐Metal‐Catalyzed Decarboxylative Cyclization of N‐Benzoyl Benzoxazinones (ChemistryOpen 5/2021)

Hiroto Uno 1,+, Daichi Fujimoto 2,+, Kyosuke Harada 2, Chika Tanaka 2, Norio Shibata 1,2,3,
PMCID: PMC8095296

Abstract

The Front Cover is inspired by the diversity in the ocean also in cyberspace. In the present research, we can synthesize diverse heterocyclic molecules having a trifluoromethyl group in a single step by changing the N‐substitution. You can see more variations of trifluoromethyl heterocycles in several papers by our group. More information can be found in the Communication by Hiroto Uno et al.

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Keywords: Benzoxazinones, copper, decarboxylation reactions, fluorinated compounds, heterocycle derivatives, intramolecular cyclization reactions


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H. Uno, D. Fujimoto, K. Harada, C. Tanaka, N. Shibata, ChemistryOpen 2021, 10, 515.


Articles from ChemistryOpen are provided here courtesy of Wiley

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