Anders Wimo, Ron Handels, Bengt Winblad, Christopher M. Black, Gunilla Johansson, Stina Salomonsson, Maria Eriksdotter, Rezaul K. Khandker
[Journal of Alzheimer’s Disease 75(3), 2020, 891-902. DOI 10.3233/JAD-191055] https://content.iospress.com/articles/journal-of-alzheimers-disease/jad191055
Because of a data extraction error, a correction is needed.
Instead of reporting 10-20-30-40 years results, figures representing 11-21-31-41 years were reported. There are no errors in the database or in the model and no impact on conclusions.
Correct tables are as below:
Table 1.
Main outcomes in the simulated cohort of 100,000 MCI-AD persons after 40 years
| 10 years | 20 years | 30 years | 40 years | |
| Cumulative cases of dementia | 87,752 | 95,433 | 95,952 | 95,969 |
| Cumulative deaths | 13,391 | 52,501 | 93,908 | 99,973 |
| Cumulative deaths with dementia | 10,275 | 48,647 | 89,892 | 95,942 |
| Cumulative deaths with AD-MCI | 3,116 | 3,854 | 4,016 | 4,030 |
| Mean PYs/person | 9.50 | 16.41 | 18.83 | 18.97 |
| Mean Pys/person with dementia | 5.67 | 12.24 | 14.63 | 14.78 |
| Mean Pys/person AD-MCI (without dementia) | 3.84 | 4.17 | 4.20 | 4.20 |
| Mean Pys/person in Mild AD | 2.84 | 4.42 | 4.93 | 4.97 |
| Mean Pys/person in Moderate AD | 2.34 | 5.90 | 7.23 | 7.31 |
| Mean PYs/person in Severe AD | 0.49 | 1.92 | 2.47 | 2.50 |
Table 2.
Cumulative cohort cost distribution (state related cumulative costs, SEK) and QALY distribution (state related cumulative) (both NPVs) during the simulated period (1 US$ = 8.56 SEK)
| Severity state | 5 years | 10 years | 20 years | 30 years | 40 years |
| Costs (million SEK) | |||||
| AD-MCI | 55,3188 | 70,918 | 76,421 | 76,760 | 76,771 |
| Mild | 31,6329 | 63,333 | 94,956 | 104,029 | 104,650 |
| Moderate | 15,7287 | 65,716 | 156,962 | 187,754 | 189,440 |
| Severe | 1,6823 | 16,990 | 62,898 | 78,900 | 79,514 |
| Total costs | 104,3627 | 216,957 | 391,238 | 447,443 | 450,375 |
| Cost/PY AD-dementia (SEK) | 249,0394 | 257,756 | 257,221 | 253,310 | 252,843 |
| QALYs | |||||
| AD-MCI | 225,166 | 283,161 | 301,214 | 302,122 | 302,146 |
| Mild | 85,415 | 163,457 | 230,727 | 246,489 | 247,384 |
| Moderate | 20,692 | 80,788 | 174,066 | 199,476 | 200,606 |
| Severe | 1,118 | 10,330 | 33,325 | 39,630 | 39,819 |
| Total QALYs | 332,391 | 537,736 | 739,332 | 787,716 | 789,956 |
Table 4: NNT 10 years: 11, NNT 20 years 28, NNTs 30 and 40 years are correct.